"188192" . . "Vnit\u0159n\u00ED l\u00E9ka\u0159stv\u00ED" . "57" . "Bikuspid\u00E1ln\u00ED aort\u00E1ln\u00ED chlope\u0148 je onemocn\u011Bn\u00ED s autozom\u00E1ln\u011B dominantn\u00ED d\u011Bdi\u010Dnost\u00ED s malou penetrac\u00ED. Nemocn\u00ED bez dilatace ascendentn\u00ED aorty, bez chlopenn\u00ED vady a bez degenerativn\u00EDch zm\u011Bn aort\u00E1ln\u00ED chlopn\u011B jsou m\u00E1lo rizikov\u00ED. Naproti tomu nemocn\u00ED s dilatac\u00ED ascendentn\u00ED aorty, s chlopenn\u00ED vadou nebo degenerac\u00ED chlopn\u011B tvo\u0159\u00ED vysoce rizikovou skupinu. Dilatace ascendentn\u00ED aorty m\u00E1 u nemocn\u00FDch s bikuspid\u00E1ln\u00ED aort\u00E1ln\u00ED chlopn\u00ED progresivn\u00ED charakter a pokra\u010Duje i po n\u00E1hrad\u011B aort\u00E1ln\u00ED chlopn\u011B. S progres\u00ED dilatace ascendentn\u00ED aorty roste i riziko jej\u00ED disekce nebo ruptury. Hlavn\u00EDm podkladem pro dilataci je zm\u011Bn\u011Bn\u00E1 kvalita st\u011Bny aorty a pravd\u011Bpodobn\u011B i mechanick\u00E9 nam\u00E1h\u00E1n\u00ED aort\u00E1ln\u00ED st\u011Bny p\u0159i asymetrick\u00E9m a turbulentn\u00EDm toku. Farmakologick\u00E1 l\u00E9\u010Dba nem\u00E1 z\u00E1sadn\u00ED vliv na zpomalen\u00ED progrese dilatace ascendentn\u00ED aorty nebo progrese vlastn\u00ED chlopenn\u00ED vady, metodou volby je l\u00E9\u010Dba chirurgick\u00E1." . . . . "Brtko, Miroslav" . "Bikuspid\u00E1ln\u00ED aort\u00E1ln\u00ED chlope\u0148 je onemocn\u011Bn\u00ED s autozom\u00E1ln\u011B dominantn\u00ED d\u011Bdi\u010Dnost\u00ED s malou penetrac\u00ED. Nemocn\u00ED bez dilatace ascendentn\u00ED aorty, bez chlopenn\u00ED vady a bez degenerativn\u00EDch zm\u011Bn aort\u00E1ln\u00ED chlopn\u011B jsou m\u00E1lo rizikov\u00ED. Naproti tomu nemocn\u00ED s dilatac\u00ED ascendentn\u00ED aorty, s chlopenn\u00ED vadou nebo degenerac\u00ED chlopn\u011B tvo\u0159\u00ED vysoce rizikovou skupinu. Dilatace ascendentn\u00ED aorty m\u00E1 u nemocn\u00FDch s bikuspid\u00E1ln\u00ED aort\u00E1ln\u00ED chlopn\u00ED progresivn\u00ED charakter a pokra\u010Duje i po n\u00E1hrad\u011B aort\u00E1ln\u00ED chlopn\u011B. S progres\u00ED dilatace ascendentn\u00ED aorty roste i riziko jej\u00ED disekce nebo ruptury. Hlavn\u00EDm podkladem pro dilataci je zm\u011Bn\u011Bn\u00E1 kvalita st\u011Bny aorty a pravd\u011Bpodobn\u011B i mechanick\u00E9 nam\u00E1h\u00E1n\u00ED aort\u00E1ln\u00ED st\u011Bny p\u0159i asymetrick\u00E9m a turbulentn\u00EDm toku. Farmakologick\u00E1 l\u00E9\u010Dba nem\u00E1 z\u00E1sadn\u00ED vliv na zpomalen\u00ED progrese dilatace ascendentn\u00ED aorty nebo progrese vlastn\u00ED chlopenn\u00ED vady, metodou volby je l\u00E9\u010Dba chirurgick\u00E1."@cs . "3"^^ . "rupture; dissection; dilatation of ascending aorta; ethiopathogenesis; bicuspid aortic valve"@en . . "RIV/00179906:_____/11:10100852!RIV12-MZ0-00179906" . "4"^^ . . "V" . "Bikuspid\u00E1ln\u00ED aort\u00E1ln\u00ED chlope\u0148 - etiopatogeneze a p\u0159irozen\u00FD v\u00FDvoj" . . "Bikuspid\u00E1ln\u00ED aort\u00E1ln\u00ED chlope\u0148 - etiopatogeneze a p\u0159irozen\u00FD v\u00FDvoj"@cs . "CZ - \u010Cesk\u00E1 republika" . "Bikuspid\u00E1ln\u00ED aort\u00E1ln\u00ED chlope\u0148 - etiopatogeneze a p\u0159irozen\u00FD v\u00FDvoj" . "Bicuspid aortic valve is a disease with autosomal dominant inheritance with small penetration. In the absence of dilatation of ascending aorta, valvular lesion or degenerative changes of valve leaflets patients are considered to belong to the low risk population. On the other hand patients with the above mentioned characteristics compose a high risk group. Dilatation of the ascending aorta in patients with bicuspid aortic valve has a progressive feature and continues even after replacement of the aortic valve. With progression of aortic dilatation the risk of aortic dissection and rupture increases. The main reasons for aortic dilatation are changes in quality of aortic wall and possibly mechanical stress of aortic wall during asymmetrical and turbulent flow. The progression of aortic dilatation or aortic valve disease is not essentialy influenced by farmacologic treatment. Surgery is the treatment of choice."@en . . "Bicuspid aortic valve - ethiopathogenesis and natural history"@en . "Telekes, Petr" . . "Bicuspid aortic valve - ethiopathogenesis and natural history"@en . "[FC377D143DE6]" . "Bikuspid\u00E1ln\u00ED aort\u00E1ln\u00ED chlope\u0148 - etiopatogeneze a p\u0159irozen\u00FD v\u00FDvoj"@cs . "0042-773X" . "Tuna, Martin" . "7"^^ . . "Voj\u00E1\u010Dek, Jan" . . . . . . "2" . . . . . "RIV/00179906:_____/11:10100852" .