"CZ - \u010Cesk\u00E1 republika" . "57" . . . . . . "9" . "[0D85294605BA]" . . . . "V prvn\u00ED \u010D\u00E1sti uv\u00E1d\u00EDme stru\u010Dn\u00FD p\u0159ehled nov\u00FDch antitrombotik, kter\u00E1 by m\u011Bla nahradit v \u0159ad\u011B indikac\u00ED kumariny a heparin. V tomto p\u0159ehledu informujeme o pentasacharidech, p\u0159\u00EDm\u00FDch inhibitorech trombinu a p\u0159\u00EDm\u00FDch inhibitorech faktoru Xa. Druh\u00E1 \u010D\u00E1st je v\u011Bnov\u00E1na vysv\u011Btlen\u00ED v\u00FDznamu p\u016Fsobk\u016F ovliv\u0148uj\u00EDc\u00EDch aktivace krevn\u00EDch desti\u010Dek, nebo\u0165 nov\u00E9 l\u00E9ky s protidesti\u010Dkov\u00FDm \u00FA\u010Dinkem p\u016Fsob\u00ED blokov\u00E1n\u00EDm t\u011Bchto z\u00E1kladn\u00EDch reakc\u00ED. P\u0159edev\u0161\u00EDm inhibice agregace desti\u010Dek stimulovan\u00E9 ADP je sm\u011Brem, kter\u00FDm se ub\u00EDr\u00E1 modern\u00ED protidesti\u010Dkov\u00E1 terapie, sni\u017Euj\u00EDc\u00ED riziko arteri\u00E1ln\u00EDch okluz\u00ED."@cs . "7"^^ . "We first present a brief overview of new antithrombotic agents that are assumed to replace coumarines and heparin in many indications; this overview provides information on pentasaccharides, direct thrombin inhibitors and direct factor Xa inhibitors. Secondly, since the new drugs with antiplatelet effect act through blockade of the reactions involved in blood platelet activation, we review and discuss the substances that interfere with this process. The current antiplatelet therapy focuses mainly on an inhibition of platelet aggregation stimulated by ADP, reducing the risk of arterial occlusions."@en . . . "New antithrombotics in the prevention of venous thromboembolia and new anti-platelet drugs"@en . "V prvn\u00ED \u010D\u00E1sti uv\u00E1d\u00EDme stru\u010Dn\u00FD p\u0159ehled nov\u00FDch antitrombotik, kter\u00E1 by m\u011Bla nahradit v \u0159ad\u011B indikac\u00ED kumariny a heparin. V tomto p\u0159ehledu informujeme o pentasacharidech, p\u0159\u00EDm\u00FDch inhibitorech trombinu a p\u0159\u00EDm\u00FDch inhibitorech faktoru Xa. Druh\u00E1 \u010D\u00E1st je v\u011Bnov\u00E1na vysv\u011Btlen\u00ED v\u00FDznamu p\u016Fsobk\u016F ovliv\u0148uj\u00EDc\u00EDch aktivace krevn\u00EDch desti\u010Dek, nebo\u0165 nov\u00E9 l\u00E9ky s protidesti\u010Dkov\u00FDm \u00FA\u010Dinkem p\u016Fsob\u00ED blokov\u00E1n\u00EDm t\u011Bchto z\u00E1kladn\u00EDch reakc\u00ED. P\u0159edev\u0161\u00EDm inhibice agregace desti\u010Dek stimulovan\u00E9 ADP je sm\u011Brem, kter\u00FDm se ub\u00EDr\u00E1 modern\u00ED protidesti\u010Dkov\u00E1 terapie, sni\u017Euj\u00EDc\u00ED riziko arteri\u00E1ln\u00EDch okluz\u00ED." . "Vnit\u0159n\u00ED l\u00E9ka\u0159stv\u00ED" . "Nov\u00E1 antitrombotika v prevenci \u017Eiln\u00ED tromboembolie a nov\u00E9 protidesti\u010Dkov\u00E9 l\u00E9ky" . . . "V, Z(MZ0FNHK2005)" . . "Nov\u00E1 antitrombotika v prevenci \u017Eiln\u00ED tromboembolie a nov\u00E9 protidesti\u010Dkov\u00E9 l\u00E9ky"@cs . "Mal\u00FD, Radovan" . "RIV/00179906:_____/11:10100190" . . "New antithrombotics in the prevention of venous thromboembolia and new anti-platelet drugs"@en . . . "Nov\u00E1 antitrombotika v prevenci \u017Eiln\u00ED tromboembolie a nov\u00E9 protidesti\u010Dkov\u00E9 l\u00E9ky" . "antiplatelet drugs; rivaroxaban; dabigatran; fondaparinux"@en . "Pecka, Miroslav" . "0042-773X" . "Mal\u00FD, Jaroslav" . . "3"^^ . "Nov\u00E1 antitrombotika v prevenci \u017Eiln\u00ED tromboembolie a nov\u00E9 protidesti\u010Dkov\u00E9 l\u00E9ky"@cs . . . . "RIV/00179906:_____/11:10100190!RIV12-MZ0-00179906" . "216369" . "3"^^ .