. "Prim\u00E1rn\u00ED lymfomy centr\u00E1ln\u00EDho nervov\u00E9ho syst\u00E9mu" . "Primary central nervous system lymphomas"@en . "5"^^ . "Mal\u00FD, Jaroslav" . "CZ - \u010Cesk\u00E1 republika" . "Vnit\u0159n\u00ED l\u00E9ka\u0159stv\u00ED" . "5"^^ . "0042-773X" . . . "Primary central nervous system lymphomas"@en . . . . . "Prim\u00E1rn\u00ED lymfomy centr\u00E1ln\u00EDho nervov\u00E9ho syst\u00E9mu (PCNSL) jsou vz\u00E1cn\u00E9 extranod\u00E1ln\u00ED lymfomy (t\u00E9m\u011B\u0159 v\u017Edy ne-Hodgkinovy) a tvo\u0159\u00ED asi 3-4% v\u0161ech mozkov\u00FDch n\u00E1dor\u016F. Z hlediska v\u011Bku jde typicky o onemocn\u011Bn\u00ED pacient\u016F star\u0161\u00EDch 60 let. Klinick\u00E1 symptomatologie je r\u016Fznorod\u00E1 a odr\u00E1\u017E\u00ED m\u00EDsta posti\u017Een\u00ED nervov\u00FDch struktur. Z\u00E1kladem pro stanoven\u00ED diagn\u00F3zy je magnetick\u00E1 rezonance mozku a n\u00E1sledn\u00E9 histologick\u00E9 vy\u0161et\u0159en\u00ED vzorku mozkov\u00E9 tk\u00E1n\u011B z\u00EDskan\u00E9 stereotaktickou biopsi\u00ED. Hlavn\u00EDm principem l\u00E9\u010Dby je pod\u00E1n\u00ED intenzivn\u00ED kombinovan\u00E9 chemoterapie na b\u00E1zi vysok\u00FDch d\u00E1vek metotrex\u00E1tu (HD-MTX) a radioterapie, kter\u00E1 v\u0161ak nen\u00ED v sou\u010Dasn\u00E9 dob\u011B pou\u017E\u00EDv\u00E1na u pacient\u016F star\u0161\u00EDch 60 let pro vysok\u00E9 riziko pozdn\u00ED neurologick\u00E9 toxicity. L\u00E9\u010Dba by m\u011Bla b\u00FDt zah\u00E1jena co nejd\u0159\u00EDve po stanoven\u00ED diagn\u00F3zy, pozdn\u00ED zah\u00E1jen\u00ED vede ke zkr\u00E1cen\u00ED celkov\u00E9ho p\u0159e\u017Eit\u00ED."@cs . "Prim\u00E1rn\u00ED lymfomy centr\u00E1ln\u00EDho nervov\u00E9ho syst\u00E9mu"@cs . . "RIV/00179906:_____/10:10070312" . "56" . . . "Prim\u00E1rn\u00ED lymfomy centr\u00E1ln\u00EDho nervov\u00E9ho syst\u00E9mu (PCNSL) jsou vz\u00E1cn\u00E9 extranod\u00E1ln\u00ED lymfomy (t\u00E9m\u011B\u0159 v\u017Edy ne-Hodgkinovy) a tvo\u0159\u00ED asi 3-4% v\u0161ech mozkov\u00FDch n\u00E1dor\u016F. Z hlediska v\u011Bku jde typicky o onemocn\u011Bn\u00ED pacient\u016F star\u0161\u00EDch 60 let. Klinick\u00E1 symptomatologie je r\u016Fznorod\u00E1 a odr\u00E1\u017E\u00ED m\u00EDsta posti\u017Een\u00ED nervov\u00FDch struktur. Z\u00E1kladem pro stanoven\u00ED diagn\u00F3zy je magnetick\u00E1 rezonance mozku a n\u00E1sledn\u00E9 histologick\u00E9 vy\u0161et\u0159en\u00ED vzorku mozkov\u00E9 tk\u00E1n\u011B z\u00EDskan\u00E9 stereotaktickou biopsi\u00ED. Hlavn\u00EDm principem l\u00E9\u010Dby je pod\u00E1n\u00ED intenzivn\u00ED kombinovan\u00E9 chemoterapie na b\u00E1zi vysok\u00FDch d\u00E1vek metotrex\u00E1tu (HD-MTX) a radioterapie, kter\u00E1 v\u0161ak nen\u00ED v sou\u010Dasn\u00E9 dob\u011B pou\u017E\u00EDv\u00E1na u pacient\u016F star\u0161\u00EDch 60 let pro vysok\u00E9 riziko pozdn\u00ED neurologick\u00E9 toxicity. L\u00E9\u010Dba by m\u011Bla b\u00FDt zah\u00E1jena co nejd\u0159\u00EDve po stanoven\u00ED diagn\u00F3zy, pozdn\u00ED zah\u00E1jen\u00ED vede ke zkr\u00E1cen\u00ED celkov\u00E9ho p\u0159e\u017Eit\u00ED." . . "S, Z(MZ0FNHK2005)" . . . "neurotoxicity; radiotherapy; methotrexate; chemotherapy; Primary central nervous system lymphomas"@en . "[678CADB74458]" . . "\u017D\u00E1k, Pavel" . . . . "8" . . "Primary central nervous system lymphoma (PCNSL) is a rare form of extranodal lymphoma (nearly always non-Hodgkin's) and accounts for approximately 3 to 4% of primary brain tumors. PCNSL typically affect patients older than 60 years. Clinical features are variable and reflect the location of central nervous system lesion. Magnetic resonance imaging and stereotactic biopsy are the most important tools for diagnostic assessment. Chemotherapy based on high-dose of methotrexate (HD-MTX) and whole brain radiotherapy are the cornerstones of treatment. Radiotherapy is usually omitted in individuals older than 60 years because of high risk of unacceptable delayed neurotoxicity. Treatment of PCNSL should be started as soon as possible after diagnosis because delay in treatment may shorten the patient's survival."@en . "RIV/00179906:_____/10:10070312!RIV11-MZ0-00179906" . "Belada, David" . . . . "Smolej, Luk\u00E1\u0161" . "Hrudkov\u00E1, Monika" . "Prim\u00E1rn\u00ED lymfomy centr\u00E1ln\u00EDho nervov\u00E9ho syst\u00E9mu"@cs . "6"^^ . . "Prim\u00E1rn\u00ED lymfomy centr\u00E1ln\u00EDho nervov\u00E9ho syst\u00E9mu" . "281683" .