"Hrabovsk\u00FD, Du\u0161an" . "erapie bolesti se stala sou\u010D\u00E1st\u00ED funk\u010Dn\u00ED stereotaktick\u00E9 neurochirurgie \u010Dasn\u011B po proveden\u00ED prvn\u00ED stereotaktick\u00E9 operace mozku v roce 1946. C\u00EDlem stereotaktick\u00FDch v\u00FDkon\u016F v terapii bolesti je ovlivn\u011Bn\u00ED struktur a drah zodpov\u011Bdn\u00FDch za p\u0159enos bolestiv\u00FDch stimul\u016F a d\u00E1vaj\u00EDc\u00EDch podklad emo\u010Dn\u00EDm proces\u016Fm spojen\u00FDm s vn\u00EDm\u00E1n\u00EDm bolesti. Podobn\u011B jako u dal\u0161\u00EDch stereotaktick\u00FDch funk\u010Dn\u00EDch v\u00FDkon\u016F (poruchy pohybu, farmakorezistentn\u00ED epilepsie, psychiatrick\u00E1 onemocn\u011Bn\u00ED) je mo\u017En\u00E9 stereotaktick\u00E9 operace v terapii bolesti rozd\u011Blit na skupinu v\u00FDkon\u016F lezion\u00E1ln\u00EDch - destruk\u010Dn\u00EDch (anatomick\u00E1 destrukce c\u00EDlov\u00E9 struktury - nej\u010Dast\u011Bji elektrotermokoagulac\u00ED) a stimula\u010Dn\u00EDch - neuromodula\u010Dn\u00EDch (ovlivn\u011Bn\u00ED zvolen\u00E9 oblasti elektrickou stimulac\u00ED pomoc\u00ED implantovan\u00E9ho gener\u00E1toru). Podm\u00EDnkou pro vyu\u017Eit\u00ED stereotaktick\u00E9 opera\u010Dn\u00ED techniky v terapii bolesti byly nov\u00E9 poznatky v oblasti patofyziologie bolesti, spolehliv\u00E9 stereotaktick\u00E9 opera\u010Dn\u00ED syst\u00E9my, rozvoj neuroradiologick\u00FDch a elektrofyziologick\u00FDch technik pro identifikaci c\u00EDlov\u00FDch struktur a v\u00FDvoj implantabiln\u00EDch bateri\u00ED. C\u00EDlov\u00FDmi strukturami lezion\u00E1ln\u00EDch v\u00FDkon\u016F v terapii bolesti v historii byly nap\u0159\u00EDklad struktury m\u00EDchy a mozkov\u00E9ho kmene, hypotalamu a hypof\u00FDzy, specifick\u00E1 i nespecifick\u00E1 j\u00E1dra talamu a oblast cingula. Nev\u00FDhodou lezion\u00E1ln\u00EDch v\u00FDkon\u016F je ireverzibilita destrukce c\u00EDlov\u00E9 struktury a tedy ne\u017E\u00E1douc\u00EDch \u00FA\u010Dink\u016F v\u00FDkonu. V sou\u010Dasnosti jsou prov\u00E1d\u011Bny pouze ojedin\u011Ble. V\u00FDhodou stereotaktick\u00FDch neuromodula\u010Dn\u00EDch v\u00FDkon\u016F je minimalizace rozsahu anatomick\u00E9 l\u00E9ze a mo\u017Enost modulace \u00FA\u010Dink\u016F stimula\u010Dn\u00ED terapie zm\u011Bnou stimula\u010Dn\u00EDch parametr\u016F." . . . . . "Bolest" . "H\u0159ib, Radovan" . "Stereotaktick\u00E1 opera\u010Dn\u00ED technika v terapii bolesti - historie a sou\u010Dasn\u00E9 mo\u017Enosti"@cs . . "Stereotaktick\u00E1 opera\u010Dn\u00ED technika v terapii bolesti - historie a sou\u010Dasn\u00E9 mo\u017Enosti" . . . "\u0158\u00EDha, Ivo" . "5"^^ . "Treatment of intractable pain became an integral part of functional stereotactical neurosurgery shortly after the first stereot actic brain surgery was performed in 1946. The aim of stereotactical surgeries in the treatment of pain is the modulation of structures and neural pathways respon- sible for the transmission of painful stimuli and underlying emotional processes associated with pain perception. Similarly to other stereotacti- cal functional surgeries (movement disorders, intractable epilepsy, treatment resistant psychiatric problems) the stereotactica l surgeries aiming to treat pain can be divided into lesional surgeries - destructive (anatomical destruction of target structure - using electroc oagulation in the majority of cases and a stimulation surgeries - neuromodulation (modulation of the target structure by means of the implantable generato r). The necessary preconditions for the use of stereotactical surgical technique for pain treatment were the new knowledge in the field of pain p athophysiology, reliable stereotactic frame based systems, the development of radiological and electrophysiological techniques for target structure iden tification and confir- mation and the progress in the field of implantable generators. During history the target structures for stereotactic pain trea tment were spinal cord and brainstem regions, hypothalamus, pituitary gland, specific and non specific thalamic nuclei and cingulate gyrus. Irreversib ility of targ et structure destruction and therefore also of side effects are the principal disadvantages of lesional surgeries. Lesional surgeries are th erefore only exceptio- nally performed nowadays. The main advantageous features of stereotactic neuromodulation system are minimalisation of the exten t of anatomi- cal lesion and the possibility to modulate the effect of stimulation by changing the stimulation parameters."@en . . "16" . . . "107958" . . "1212-0634" . "Stereotactic surgery in pain treatment - history and contemporary possibilities"@en . "8"^^ . "5"^^ . . . "1" . . . "I, P(ED1.1.00/02.0068)" . . "Stereotactic surgery in pain treatment - history and contemporary possibilities"@en . "CZ - \u010Cesk\u00E1 republika" . "Chrastina, Jan" . . "[7FE258118030]" . "Stereotaktick\u00E1 opera\u010Dn\u00ED technika v terapii bolesti - historie a sou\u010Dasn\u00E9 mo\u017Enosti" . . "Stereotaktick\u00E1 opera\u010Dn\u00ED technika v terapii bolesti - historie a sou\u010Dasn\u00E9 mo\u017Enosti"@cs . . "erapie bolesti se stala sou\u010D\u00E1st\u00ED funk\u010Dn\u00ED stereotaktick\u00E9 neurochirurgie \u010Dasn\u011B po proveden\u00ED prvn\u00ED stereotaktick\u00E9 operace mozku v roce 1946. C\u00EDlem stereotaktick\u00FDch v\u00FDkon\u016F v terapii bolesti je ovlivn\u011Bn\u00ED struktur a drah zodpov\u011Bdn\u00FDch za p\u0159enos bolestiv\u00FDch stimul\u016F a d\u00E1vaj\u00EDc\u00EDch podklad emo\u010Dn\u00EDm proces\u016Fm spojen\u00FDm s vn\u00EDm\u00E1n\u00EDm bolesti. Podobn\u011B jako u dal\u0161\u00EDch stereotaktick\u00FDch funk\u010Dn\u00EDch v\u00FDkon\u016F (poruchy pohybu, farmakorezistentn\u00ED epilepsie, psychiatrick\u00E1 onemocn\u011Bn\u00ED) je mo\u017En\u00E9 stereotaktick\u00E9 operace v terapii bolesti rozd\u011Blit na skupinu v\u00FDkon\u016F lezion\u00E1ln\u00EDch - destruk\u010Dn\u00EDch (anatomick\u00E1 destrukce c\u00EDlov\u00E9 struktury - nej\u010Dast\u011Bji elektrotermokoagulac\u00ED) a stimula\u010Dn\u00EDch - neuromodula\u010Dn\u00EDch (ovlivn\u011Bn\u00ED zvolen\u00E9 oblasti elektrickou stimulac\u00ED pomoc\u00ED implantovan\u00E9ho gener\u00E1toru). Podm\u00EDnkou pro vyu\u017Eit\u00ED stereotaktick\u00E9 opera\u010Dn\u00ED techniky v terapii bolesti byly nov\u00E9 poznatky v oblasti patofyziologie bolesti, spolehliv\u00E9 stereotaktick\u00E9 opera\u010Dn\u00ED syst\u00E9my, rozvoj neuroradiologick\u00FDch a elektrofyziologick\u00FDch technik pro identifikaci c\u00EDlov\u00FDch struktur a v\u00FDvoj implantabiln\u00EDch bateri\u00ED. C\u00EDlov\u00FDmi strukturami lezion\u00E1ln\u00EDch v\u00FDkon\u016F v terapii bolesti v historii byly nap\u0159\u00EDklad struktury m\u00EDchy a mozkov\u00E9ho kmene, hypotalamu a hypof\u00FDzy, specifick\u00E1 i nespecifick\u00E1 j\u00E1dra talamu a oblast cingula. Nev\u00FDhodou lezion\u00E1ln\u00EDch v\u00FDkon\u016F je ireverzibilita destrukce c\u00EDlov\u00E9 struktury a tedy ne\u017E\u00E1douc\u00EDch \u00FA\u010Dink\u016F v\u00FDkonu. V sou\u010Dasnosti jsou prov\u00E1d\u011Bny pouze ojedin\u011Ble. V\u00FDhodou stereotaktick\u00FDch neuromodula\u010Dn\u00EDch v\u00FDkon\u016F je minimalizace rozsahu anatomick\u00E9 l\u00E9ze a mo\u017Enost modulace \u00FA\u010Dink\u016F stimula\u010Dn\u00ED terapie zm\u011Bnou stimula\u010Dn\u00EDch parametr\u016F."@cs . "Nov\u00E1k, Zden\u011Bk" . . "lesional stereotaxy; deep brain stimulation; neuromodulation; pain surgery; stereotaxy"@en . "RIV/00159816:_____/13:00060869" . "RIV/00159816:_____/13:00060869!RIV14-MZ0-00159816" . . . .