"CZ - \u010Cesk\u00E1 republika" . "2" . . "A severe course of acquired haemophilia A \u2013 case report"@en . "Circulating anticoagulants are endogenous substances interfering in the coagulation cascade, which may even lead to severe bleeding. In the vast majority of cases, these substances are immunoglobulins, production of which may be induced by the administration of coagulation factor concentrates, e. g. in haemophilia patients. However, they can also be associated with malignant neoplasms, drug interactions and old age. The authors present a case report of an 84-years-old female patient in whom factor VII inhibitor was detected following urological surgery. Although diagnostic tests for anticoagulants were negative prior to surgery, the patient developed coagulation inhibitors afterwards \u2013 most probably due to numerous blood transfusions. The patient died on the 5th day in spite of early detection of anticoagulant production and subsequent complex therapy."@en . . . "Z\u00EDskan\u00E1 hemofile A s t\u011B\u017Ek\u00FDm pr\u016Fb\u011Bhem \u2013 kazuistika." . "RIV/00159816:_____/12:#0000834!RIV13-MZ0-00159816" . . "RIV/00159816:_____/12:#0000834" . . "4"^^ . . "Z\u00EDskan\u00E1 hemofile A s t\u011B\u017Ek\u00FDm pr\u016Fb\u011Bhem \u2013 kazuistika."@cs . . "coagulation; circulating anticoagulant; factor VIII inhibitor"@en . . "Z\u00EDskan\u00E1 hemofile A s t\u011B\u017Ek\u00FDm pr\u016Fb\u011Bhem \u2013 kazuistika." . "3"^^ . . . "1214-2158" . . "182382" . "I, N" . "[1BFF74EA2946]" . "Cirkuluj\u00EDc\u00ED antikoagulancia jsou endogenn\u011B produkovan\u00E9 substance, kter\u00E9 zasahuj\u00ED na r\u016Fzn\u00FDch \u00FArovn\u00EDch do procesu krevn\u00EDho sr\u00E1\u017Een\u00ED, a mohou tak v\u00E9st i ke klinicky z\u00E1va\u017En\u00E9mu krv\u00E1cen\u00ED. V naprost\u00E9 v\u011Bt\u0161in\u011B p\u0159\u00EDpad\u016F se jedn\u00E1 o imunoglobuliny, kter\u00E9 se mohou za\u010D\u00EDt tvo\u0159it v souvislosti s transfuz\u00ED koncentr\u00E1t\u016F koagula\u010Dn\u00EDch faktor\u016F, nap\u0159. p\u0159i l\u00E9\u010Db\u011B hemofilie. Mohou se v\u0161ak vyskytnout i v jin\u00FDch p\u0159\u00EDpadech, \u010Dasto ve spojen\u00ED s malignitami, l\u00E9kov\u00FDmi interakcemi a vy\u0161\u0161\u00EDm v\u011Bkem. P\u0159edkl\u00E1d\u00E1me kazuistiku 84let\u00E9 pacientky, u kter\u00E9 byl diagnostikov\u00E1n inhibitor faktoru VIII po opakovan\u00FDch urologick\u00FDch operac\u00EDch. P\u0159esto\u017Ee p\u0159edopera\u010Dn\u011B byla laboratorn\u00ED diagnostika negativn\u00ED, do\u0161lo v poopera\u010Dn\u00EDm pr\u016Fb\u011Bhu k indukci inhibitoru, pravd\u011Bpodobn\u011B v souvislosti s l\u00E9\u010Dbou krv\u00E1civ\u00FDch projev\u016F masivn\u00EDmi p\u0159evody krevn\u00EDch deriv\u00E1t\u016F. I p\u0159es \u010Dasnou detekci cirkuluj\u00EDc\u00EDho antikoagulans a plnou terapii s pod\u00E1n\u00EDm rekombinantn\u00EDch faktor\u016F sr\u00E1\u017Een\u00ED, pacientka zem\u0159ela 5. den hospitalizace."@cs . . "A severe course of acquired haemophilia A \u2013 case report"@en . "3"^^ . . "Z\u00EDskan\u00E1 hemofile A s t\u011B\u017Ek\u00FDm pr\u016Fb\u011Bhem \u2013 kazuistika."@cs . "\u0160r\u00E1mek, Vladim\u00EDr" . "23" . "Cirkuluj\u00EDc\u00ED antikoagulancia jsou endogenn\u011B produkovan\u00E9 substance, kter\u00E9 zasahuj\u00ED na r\u016Fzn\u00FDch \u00FArovn\u00EDch do procesu krevn\u00EDho sr\u00E1\u017Een\u00ED, a mohou tak v\u00E9st i ke klinicky z\u00E1va\u017En\u00E9mu krv\u00E1cen\u00ED. V naprost\u00E9 v\u011Bt\u0161in\u011B p\u0159\u00EDpad\u016F se jedn\u00E1 o imunoglobuliny, kter\u00E9 se mohou za\u010D\u00EDt tvo\u0159it v souvislosti s transfuz\u00ED koncentr\u00E1t\u016F koagula\u010Dn\u00EDch faktor\u016F, nap\u0159. p\u0159i l\u00E9\u010Db\u011B hemofilie. Mohou se v\u0161ak vyskytnout i v jin\u00FDch p\u0159\u00EDpadech, \u010Dasto ve spojen\u00ED s malignitami, l\u00E9kov\u00FDmi interakcemi a vy\u0161\u0161\u00EDm v\u011Bkem. P\u0159edkl\u00E1d\u00E1me kazuistiku 84let\u00E9 pacientky, u kter\u00E9 byl diagnostikov\u00E1n inhibitor faktoru VIII po opakovan\u00FDch urologick\u00FDch operac\u00EDch. P\u0159esto\u017Ee p\u0159edopera\u010Dn\u011B byla laboratorn\u00ED diagnostika negativn\u00ED, do\u0161lo v poopera\u010Dn\u00EDm pr\u016Fb\u011Bhu k indukci inhibitoru, pravd\u011Bpodobn\u011B v souvislosti s l\u00E9\u010Dbou krv\u00E1civ\u00FDch projev\u016F masivn\u00EDmi p\u0159evody krevn\u00EDch deriv\u00E1t\u016F. I p\u0159es \u010Dasnou detekci cirkuluj\u00EDc\u00EDho antikoagulans a plnou terapii s pod\u00E1n\u00EDm rekombinantn\u00EDch faktor\u016F sr\u00E1\u017Een\u00ED, pacientka zem\u0159ela 5. den hospitalizace." . "Anesteziologie a intenzivn\u00ED medic\u00EDna" . . . . . "Chobola, Milo\u0161" . "Hruda, Jan" . .