. "Koc\u00E1k, I." . . . "P(NS10101), S, V" . "Kost\u0159ica, Rom" . . "RIV/00159816:_____/10:#0000837!RIV13-MZ0-00159816" . . "RIV/00159816:_____/10:#0000837" . "CZ - \u010Cesk\u00E1 republika" . . . . "277720" . "Lakom\u00FD, R." . . . "Ototoxicita indukovan\u00E1 cisplatinou - klinick\u00E9 sledov\u00E1n\u00ED a stanoven\u00ED individu\u00E1ln\u00ED senzitivity"@cs . "4" . . "6"^^ . . "[BAC241ECE225]" . "Talach, Tom\u00E1\u0161" . "Klinick\u00FD obraz ototoxicity cisplatiny zahrnuje jednostrannou \u010Di oboustrannou percep\u010Dn\u00ED nedosl\u00FDchavost (reverzibiln\u00ED nebo trvalou) a tinnitus. Tato ototoxicita je vysoce z\u00E1visl\u00E1 na individu\u00E1ln\u00ED senzitivit\u011B; \u010Dasto v\u00EDce ne\u017E na celkov\u00E9 podan\u00E9 d\u00E1vce. Byla provedena pilotn\u00ED studie sleduj\u00EDc\u00ED projevy ototoxicity indukovan\u00E9 terapeutick\u00FDmi d\u00E1vkami cisplatiny u t\u0159\u00ED skupin pacient\u016F. Byla ov\u011B\u0159ena vy\u0161\u0161\u00ED senzitivita m\u011B\u0159en\u00ED oto akustick\u00FDch emis\u00ED ne\u017E klasick\u00E9ho t\u00F3nov\u00E9ho audiogramu v\u016F\u010Di kone\u010Dn\u00E9mu ototoxick\u00E9mu efektu a jejich prediktivn\u00ED v\u00FDznam v klinick\u00E9m sledov\u00E1n\u00ED. Nebyl prok\u00E1z\u00E1n v\u00FDznam v\u00FDskytu tinnitujako prediktivn\u00EDho faktoru pro po\u0161kozen\u00ED prahu sluchu. V\u00FDstupem pilotn\u00ED studie bylo i zvolen\u00ED pacient\u016F s extragonad\u00E1ln\u00EDmi germinativn\u00EDmi n\u00E1dory a s testikul\u00E1rn\u00EDmi n\u00E1dory l\u00E9\u010Den\u00FDmi cisplatinou, jako nejvhodn\u011Bj\u0161\u00EDch pro n\u00E1sledn\u00FD v\u00FDzkumn\u00FD z\u00E1m\u011Br. Krom\u011B klinick\u00FDch vy\u0161et\u0159en\u00ED ur\u010Duj\u00EDc\u00EDch individu\u00E1ln\u00ED senzitivitu bude u nich provedena genotypizace vybran\u00FDch genov\u00FDch marker\u016F syst\u00E9mu oxidativn\u011B/antioxidativn\u00ED rovnov\u00E1hy"@cs . "59" . . . . "3"^^ . "Klinick\u00FD obraz ototoxicity cisplatiny zahrnuje jednostrannou \u010Di oboustrannou percep\u010Dn\u00ED nedosl\u00FDchavost (reverzibiln\u00ED nebo trvalou) a tinnitus. Tato ototoxicita je vysoce z\u00E1visl\u00E1 na individu\u00E1ln\u00ED senzitivit\u011B; \u010Dasto v\u00EDce ne\u017E na celkov\u00E9 podan\u00E9 d\u00E1vce. Byla provedena pilotn\u00ED studie sleduj\u00EDc\u00ED projevy ototoxicity indukovan\u00E9 terapeutick\u00FDmi d\u00E1vkami cisplatiny u t\u0159\u00ED skupin pacient\u016F. Byla ov\u011B\u0159ena vy\u0161\u0161\u00ED senzitivita m\u011B\u0159en\u00ED oto akustick\u00FDch emis\u00ED ne\u017E klasick\u00E9ho t\u00F3nov\u00E9ho audiogramu v\u016F\u010Di kone\u010Dn\u00E9mu ototoxick\u00E9mu efektu a jejich prediktivn\u00ED v\u00FDznam v klinick\u00E9m sledov\u00E1n\u00ED. Nebyl prok\u00E1z\u00E1n v\u00FDznam v\u00FDskytu tinnitujako prediktivn\u00EDho faktoru pro po\u0161kozen\u00ED prahu sluchu. V\u00FDstupem pilotn\u00ED studie bylo i zvolen\u00ED pacient\u016F s extragonad\u00E1ln\u00EDmi germinativn\u00EDmi n\u00E1dory a s testikul\u00E1rn\u00EDmi n\u00E1dory l\u00E9\u010Den\u00FDmi cisplatinou, jako nejvhodn\u011Bj\u0161\u00EDch pro n\u00E1sledn\u00FD v\u00FDzkumn\u00FD z\u00E1m\u011Br. Krom\u011B klinick\u00FDch vy\u0161et\u0159en\u00ED ur\u010Duj\u00EDc\u00EDch individu\u00E1ln\u00ED senzitivitu bude u nich provedena genotypizace vybran\u00FDch genov\u00FDch marker\u016F syst\u00E9mu oxidativn\u011B/antioxidativn\u00ED rovnov\u00E1hy" . "Ototoxicity Induced by Cisplatin - Clinical Observation and Determination of Individual Sensitivity"@en . . "Jurajda, M." . "Ototoxicita indukovan\u00E1 cisplatinou - klinick\u00E9 sledov\u00E1n\u00ED a stanoven\u00ED individu\u00E1ln\u00ED senzitivity" . "5"^^ . "Otorhinolaryngologie a foniatrie" . "Ototoxicita indukovan\u00E1 cisplatinou - klinick\u00E9 sledov\u00E1n\u00ED a stanoven\u00ED individu\u00E1ln\u00ED senzitivity"@cs . . "The clinical manifestation of ciplatin (CDDP) induced ototoxicity comprises unilateral or bilateral sensorial hearing los s (reversible or permanent) and tinnitus. The ototoxicity was shown to depend more on the individual sensitivity than on the total dose applied. The aim of the pilot study was to test (A) the effect of variable doses of CDDP and (B) efficiency of various diagnostic methods using three groups of patients. Otoacoustic emissions exhibited better predictive potential for final ototoxicity severity than classical tone audiometry. Presence of tinnitus did not predict degree of hearing loss. Based on the pilot study patients with the testicular and extragonadal germline tumors treated with CDDP were selected as an optimal study group for subsequent larger scale study. Apart from disease and treatment related parameters individual sensitivity will be assessed using genotyping of selected genetic markers in candidate genes related to oxidative/antioxidative balance."@en . "ototoxicity; cisplatin; otoacoustic emissions; tone audiometry; sensory-neural hearing loss"@en . . "Ototoxicity Induced by Cisplatin - Clinical Observation and Determination of Individual Sensitivity"@en . . "Ototoxicita indukovan\u00E1 cisplatinou - klinick\u00E9 sledov\u00E1n\u00ED a stanoven\u00ED individu\u00E1ln\u00ED senzitivity" . . "1210-7867" . . "Rottenberg, Jan" .