"Ischemic stroke is most often caused by an acute extracranial or intracranial thromboembolic lesion obstructing an artery. It has been demonstrated that recanalization is the most important modifiable predictor of a good clinical outcome. Reperfusion strategies focus on early reopening of the vessel to reestablish antegrade flow within the penumbra. Current standard therapy within 4.5 h is intravenous thrombolysis (IVT) with tissue plasminogen activator (tPA, 0.9 mg/kg body weight, maximum dose 90 mg). Thrombolytic therapy appears to be safe and effective across various types of hospitals, if the treatment is conducted by a physician with stroke expertise." . "TISSUE-PLASMINOGEN-ACTIVATOR, MECHANICAL THROMBECTOMY, RANDOMIZED-TRIAL, MERCI TRIAL, PART I, THROMBOLYSIS, INTRAARTERIAL, ULTRASOUND, MANAGEMENT, ALTEPLASE"@en . "Reperfusion Therapies for Acute Ischemic Stroke"@en . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "2"^^ . "Reperfusion Therapies for Acute Ischemic Stroke" . . "2"^^ . . "V" . "1092-8480" . "RIV/00159816:_____/10:#0000560" . . "[C33342410B2F]" . . "Mikul\u00EDk, Robert" . . "Reperfusion Therapies for Acute Ischemic Stroke" . "284838" . . . "CURRENT TREATMENT OPTIONS IN NEUROLOGY" . . "RIV/00159816:_____/10:#0000560!RIV11-MZ0-00159816" . . . . "Ischemic stroke is most often caused by an acute extracranial or intracranial thromboembolic lesion obstructing an artery. It has been demonstrated that recanalization is the most important modifiable predictor of a good clinical outcome. Reperfusion strategies focus on early reopening of the vessel to reestablish antegrade flow within the penumbra. Current standard therapy within 4.5 h is intravenous thrombolysis (IVT) with tissue plasminogen activator (tPA, 0.9 mg/kg body weight, maximum dose 90 mg). Thrombolytic therapy appears to be safe and effective across various types of hospitals, if the treatment is conducted by a physician with stroke expertise."@en . . "Reperfusion Therapies for Acute Ischemic Stroke"@en . . . "2" . . . . . . . "12"^^ . "Goldemund, David" . "12" . .