"156680" . "5"^^ . . "32" . "RIV/00098892:_____/12:#0000333" . "interferon-alpha, chronic myeloid leukemia, operational cure"@en . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . . . . "1079-9907" . "[C53CF4271355]" . "We assessed long-term outcome of 118 consecutive patients in chronic phase of chronic myeloid leukemia (CML) treated with interferon-alpha (IFN-\u03B1) in the Central and Northern Moravia region between 1989 and 2006 with focus on operational cure. The median follow-up was 82.6 months (range 12.4\u2013212.6). Eighteen (15.3%) patients achieved complete cytogenetic response (CCyR) after median 16.7 (3.7\u201340.8) months. Nine of these patients (7.6%) achieved BCR-ABL negativity in nested reverse transcriptase\u2013polymerase chain reaction [\u201Ccomplete\u201D molecular response (CMR)] and 6 of them have been operationally cured without any treatment for median 6 (4\u201310) years, while 2 continue with IFN-\u03B1 and 1 died from CML-unrelated cause. Operationally cured patients had a significantly lower percentage of initial peripheral promyelocytes, blasts, and erythroblasts than the rest of patients treated for more than 12 months (P=0.01\u20130.03). Unlike patients with sole CCyR, the majority of whom lost CCyR despite continuing IFN-\u03B1 therapy and required imatinib, patients who achieved CMR had excellent long-term outcome" . "9"^^ . "5" . "RIV/00098892:_____/12:#0000333!RIV13-MZ0-00098892" . . . "Kuba, Adam" . . "I" . . . . "We assessed long-term outcome of 118 consecutive patients in chronic phase of chronic myeloid leukemia (CML) treated with interferon-alpha (IFN-\u03B1) in the Central and Northern Moravia region between 1989 and 2006 with focus on operational cure. The median follow-up was 82.6 months (range 12.4\u2013212.6). Eighteen (15.3%) patients achieved complete cytogenetic response (CCyR) after median 16.7 (3.7\u201340.8) months. Nine of these patients (7.6%) achieved BCR-ABL negativity in nested reverse transcriptase\u2013polymerase chain reaction [\u201Ccomplete\u201D molecular response (CMR)] and 6 of them have been operationally cured without any treatment for median 6 (4\u201310) years, while 2 continue with IFN-\u03B1 and 1 died from CML-unrelated cause. Operationally cured patients had a significantly lower percentage of initial peripheral promyelocytes, blasts, and erythroblasts than the rest of patients treated for more than 12 months (P=0.01\u20130.03). Unlike patients with sole CCyR, the majority of whom lost CCyR despite continuing IFN-\u03B1 therapy and required imatinib, patients who achieved CMR had excellent long-term outcome"@en . . "Operational cures after Interferon-apha in patients with chronic myeloid leukemia in Central and Northern Moravia" . "Faber, Edgar" . "Operational cures after Interferon-apha in patients with chronic myeloid leukemia in Central and Northern Moravia" . . "Operational cures after Interferon-apha in patients with chronic myeloid leukemia in Central and Northern Moravia"@en . "Journal of Interferon & Cytokine Research" . . "Operational cures after Interferon-apha in patients with chronic myeloid leukemia in Central and Northern Moravia"@en . . "1"^^ .