. "1"^^ . "Posti\u017Een\u00ED skeletu u mnoho\u010Detn\u00E9ho myelomu"@cs . "Skeletal involvement in multiple myeloma"@en . "221902" . "Sd\u011Blen\u00ED p\u0159edkl\u00E1d\u00E1 p\u0159ehled klinick\u00FDch projev\u016F myelomov\u00E9 kostn\u00ED nemoci (MKN) a n\u00E1rys jej\u00ED slo\u017Eit\u00E9 patofyziologie v\u010Detrn\u011B koordinovan\u00FDch \u00FA\u010Dink\u016F \u0161irok\u00E9 palety regula\u010Dn\u00EDch biologick\u00FDch p\u016Fsobk\u016F moduluj\u00EDc\u00EDch proliferaci, funkci a z\u00E1nik osteoklast\u016F i osteoblast\u016F, vedouc\u00EDch k poru\u0161e kostn\u00ED homeost\u00E1zy vyzna\u010Duj\u00EDc\u00EDch se dominanc\u00ED osteoklastick\u00E9 kostn\u00ED resorpce nad osteoblasty ovl\u00E1dan\u00E9 novotvorby. Podstatn\u00E1 pozornost je v\u011Bnov\u00E1na p\u0159\u00EDnosu modern\u00EDch zobrazovac\u00EDch metod, zejm\u00E9na celot\u011Blov\u00E9 magnetick\u00E9 rezonanci a pozitronov\u00E9 emisn\u00ED tomografii/v\u00FDpo\u010Detn\u00ED tomografii i v\u00FDznamu marker\u016F kostn\u00EDho metabolismu v hodnocen\u00ED v\u00FDvoje MKN. Nen\u00ED opomenuta problematika sou\u010Dasn\u00FDch mo\u017Enost\u00ED l\u00E9\u010Dby myelomov\u00E9 kostn\u00ED nemoci, v\u010Detn\u011B srovn\u00E1n\u00ED p\u0159\u00EDnosu jednotliv\u00FDch typ\u016F bisfosfon\u00E1t\u016F i perspektivn\u00ED mo\u017Enosti c\u00EDlen\u00E9 ter\u010Dov\u00E9 terapie zam\u011B\u0159en\u00E9 na d\u00EDl\u010D\u00ED patogenetick\u00E9 aspekty kostn\u00EDho posti\u017Een\u00ED."@cs . "1212-4184" . "13" . . "RIV/00098892:_____/11:#0000161!RIV12-MZ0-00098892" . . "The paper presents an overview of clinical manifestations of myeloma bone disease (MBD), and an illustration of its complex pathophysiology including the coordinate effects of wide spectrum of regulatory biological agents, which modulate proliferation, function and decay of osteoclasts and osteoblasts that lead to the defect of bone homeostasis with dominating osteoclast bone resorption over osteoblast controlled formation. Substantial attention is drawn to the contribution of modern imaging methods, especially the whole-body magnetic resonance and positron emission tomography and computed tomography as well as the significance of bone metabolism markers in the evaluation of MBD development. We focus also at the issue of temporary treatment possibilities of myeloma bone disease, including the contribution of individual bisphosphonate types and potential possibilities of targeted therapy aimed at individual pathogenetic aspects of MBD."@en . . "[9945F9F128DB]" . "Posti\u017Een\u00ED skeletu u mnoho\u010Detn\u00E9ho myelomu"@cs . "7" . . . . . "Postgradu\u00E1ln\u00ED medic\u00EDna" . "Posti\u017Een\u00ED skeletu u mnoho\u010Detn\u00E9ho myelomu" . . "9"^^ . "RIV/00098892:_____/11:#0000161" . "Posti\u017Een\u00ED skeletu u mnoho\u010Detn\u00E9ho myelomu" . . "multiple myeloma, whole-body magnetic resonance imaging, markers of bone metabolism"@en . . . . . . . "Skeletal involvement in multiple myeloma"@en . . "Sd\u011Blen\u00ED p\u0159edkl\u00E1d\u00E1 p\u0159ehled klinick\u00FDch projev\u016F myelomov\u00E9 kostn\u00ED nemoci (MKN) a n\u00E1rys jej\u00ED slo\u017Eit\u00E9 patofyziologie v\u010Detrn\u011B koordinovan\u00FDch \u00FA\u010Dink\u016F \u0161irok\u00E9 palety regula\u010Dn\u00EDch biologick\u00FDch p\u016Fsobk\u016F moduluj\u00EDc\u00EDch proliferaci, funkci a z\u00E1nik osteoklast\u016F i osteoblast\u016F, vedouc\u00EDch k poru\u0161e kostn\u00ED homeost\u00E1zy vyzna\u010Duj\u00EDc\u00EDch se dominanc\u00ED osteoklastick\u00E9 kostn\u00ED resorpce nad osteoblasty ovl\u00E1dan\u00E9 novotvorby. Podstatn\u00E1 pozornost je v\u011Bnov\u00E1na p\u0159\u00EDnosu modern\u00EDch zobrazovac\u00EDch metod, zejm\u00E9na celot\u011Blov\u00E9 magnetick\u00E9 rezonanci a pozitronov\u00E9 emisn\u00ED tomografii/v\u00FDpo\u010Detn\u00ED tomografii i v\u00FDznamu marker\u016F kostn\u00EDho metabolismu v hodnocen\u00ED v\u00FDvoje MKN. Nen\u00ED opomenuta problematika sou\u010Dasn\u00FDch mo\u017Enost\u00ED l\u00E9\u010Dby myelomov\u00E9 kostn\u00ED nemoci, v\u010Detn\u011B srovn\u00E1n\u00ED p\u0159\u00EDnosu jednotliv\u00FDch typ\u016F bisfosfon\u00E1t\u016F i perspektivn\u00ED mo\u017Enosti c\u00EDlen\u00E9 ter\u010Dov\u00E9 terapie zam\u011B\u0159en\u00E9 na d\u00EDl\u010D\u00ED patogenetick\u00E9 aspekty kostn\u00EDho posti\u017Een\u00ED." . "1"^^ . . "\u0160\u010Dudla, Vlastimil" . "P(NT12215), Z(MSM6198959205)" . "CZ - \u010Cesk\u00E1 republika" .