"Klinick\u00E1 farmakologie a farmacie" . "1"^^ . "http://www.klinickafarmakologie.cz/pdfs/far/2011/03/04.pdf" . . "RIV/00098892:_____/11:#0000104!RIV12-MZ0-00098892" . "C\u00EDl studie: Posoudit vliv kontinu\u00E1ln\u00ED venoven\u00F3zn\u00ED hemofiltrace na \u00FA\u010Dinnost d\u00E1vkov\u00E1n\u00ED vankomycinu u kriticky nemocn\u00FDch v sepsi. Za pou\u017Eit\u00ED farmakokinetick\u00E9ho modelu jsme se pokusili naj\u00EDt individu\u00E1ln\u00ED d\u00E1vkovac\u00ED re\u017Eimy pro prvn\u00ED den l\u00E9\u010Dby a dos\u00E1hnout p\u0159itom po\u017Eadovan\u00E9 AUC/MIC90. V\u00FDsledky: Jen u \u010Dty\u0159 pacient\u016F (27 %) byla na konci prvn\u00EDho dne l\u00E9\u010Dby \u00FAdoln\u00ED koncentrace VAN nad po\u017Eadovan\u00FDmi 10 mg/l. Zkr\u00E1cen\u00EDm d\u00E1vkovac\u00EDho intervalu ze 12 na 8 hodin a z 24 na 12 hodin by se p\u0159i MIC90 = 1 mg/l zv\u00FD\u0161ila mo\u017Enost dos\u00E1hnout spr\u00E1vn\u00E9 AUC/MIC90 ze 27 % na 87 %, stejn\u011B jako v p\u0159\u00EDpad\u011B nav\u00FD\u0161en\u00ED \u00FAvodn\u00ED d\u00E1vky o 0,5 g. \u017D\u00E1v\u011Br: Obvykle pou\u017E\u00EDvan\u00E9 d\u00E1vkov\u00E1n\u00ED vankomycinu nevede u kriticky nemocn\u00FDch l\u00E9\u010Den\u00FDch CVVH b\u011Bhem prvn\u00EDho dne k adekv\u00E1tn\u00ED \u00FAdoln\u00ED koncentraci. V\u00FDsledn\u00E9 AUC/MIC90 je dostate\u010Dn\u00E9 jen u patogen\u016F s n\u00EDzk\u00FDm MIC90. Intenzifikovan\u00E9 d\u00E1vkov\u00E1n\u00ED by zv\u00FD\u0161ilo \u00FA\u010Dinnost l\u00E9\u010Dby jen p\u0159i MIC90 = 1,0. Pacienti v sepsi vy\u017Eaduj\u00ED p\u0159i CVVH pod\u00E1n\u00ED v\u00FDrazn\u011B vy\u0161\u0161\u00ED \u00FAvodn\u00ED d\u00E1vky, aby byla v tomto kritick\u00E9m obdob\u00ED zaji\u0161t\u011Bna spr\u00E1vn\u00E1 \u00FA\u010Dinnost l\u00E9\u010Dby." . "D\u00E1vkov\u00E1n\u00ED vankomycinu p\u0159i kontinu\u00E1ln\u00ED n\u00E1hrad\u011B funkce ledvin" . "P(NS10309), V" . . "D\u00E1vkov\u00E1n\u00ED vankomycinu p\u0159i kontinu\u00E1ln\u00ED n\u00E1hrad\u011B funkce ledvin"@cs . . "vancomycin therapeutic drug monitoring sepsis acute kidney injury"@en . "D\u00E1vkov\u00E1n\u00ED vankomycinu p\u0159i kontinu\u00E1ln\u00ED n\u00E1hrad\u011B funkce ledvin" . "RIV/00098892:_____/11:#0000104" . . . "Dosage of vancomycin during continuous renal replacement therapy"@en . "3" . . . "[B9B0563E889F]" . . "192984" . "Dosage of vancomycin during continuous renal replacement therapy"@en . "C\u00EDl studie: Posoudit vliv kontinu\u00E1ln\u00ED venoven\u00F3zn\u00ED hemofiltrace na \u00FA\u010Dinnost d\u00E1vkov\u00E1n\u00ED vankomycinu u kriticky nemocn\u00FDch v sepsi. Za pou\u017Eit\u00ED farmakokinetick\u00E9ho modelu jsme se pokusili naj\u00EDt individu\u00E1ln\u00ED d\u00E1vkovac\u00ED re\u017Eimy pro prvn\u00ED den l\u00E9\u010Dby a dos\u00E1hnout p\u0159itom po\u017Eadovan\u00E9 AUC/MIC90. V\u00FDsledky: Jen u \u010Dty\u0159 pacient\u016F (27 %) byla na konci prvn\u00EDho dne l\u00E9\u010Dby \u00FAdoln\u00ED koncentrace VAN nad po\u017Eadovan\u00FDmi 10 mg/l. Zkr\u00E1cen\u00EDm d\u00E1vkovac\u00EDho intervalu ze 12 na 8 hodin a z 24 na 12 hodin by se p\u0159i MIC90 = 1 mg/l zv\u00FD\u0161ila mo\u017Enost dos\u00E1hnout spr\u00E1vn\u00E9 AUC/MIC90 ze 27 % na 87 %, stejn\u011B jako v p\u0159\u00EDpad\u011B nav\u00FD\u0161en\u00ED \u00FAvodn\u00ED d\u00E1vky o 0,5 g. \u017D\u00E1v\u011Br: Obvykle pou\u017E\u00EDvan\u00E9 d\u00E1vkov\u00E1n\u00ED vankomycinu nevede u kriticky nemocn\u00FDch l\u00E9\u010Den\u00FDch CVVH b\u011Bhem prvn\u00EDho dne k adekv\u00E1tn\u00ED \u00FAdoln\u00ED koncentraci. V\u00FDsledn\u00E9 AUC/MIC90 je dostate\u010Dn\u00E9 jen u patogen\u016F s n\u00EDzk\u00FDm MIC90. Intenzifikovan\u00E9 d\u00E1vkov\u00E1n\u00ED by zv\u00FD\u0161ilo \u00FA\u010Dinnost l\u00E9\u010Dby jen p\u0159i MIC90 = 1,0. Pacienti v sepsi vy\u017Eaduj\u00ED p\u0159i CVVH pod\u00E1n\u00ED v\u00FDrazn\u011B vy\u0161\u0161\u00ED \u00FAvodn\u00ED d\u00E1vky, aby byla v tomto kritick\u00E9m obdob\u00ED zaji\u0161t\u011Bna spr\u00E1vn\u00E1 \u00FA\u010Dinnost l\u00E9\u010Dby."@cs . "6"^^ . "D\u00E1vkov\u00E1n\u00ED vankomycinu p\u0159i kontinu\u00E1ln\u00ED n\u00E1hrad\u011B funkce ledvin"@cs . . . "6"^^ . "Zah\u00E1lkov\u00E1, Jana" . "The aim of the study was to analyze the influence of continuous venovenous hemofiltration (CVVH) on efficacy of vancomycin dosage in critically ill septic patients (pts). Using pharmacokinetic modelling we tried to find an individual dosing regimen for the first day and to optimize pts\u00B4 chance of achieving sufficient AUC/MIC90 values. lure, n = 6). Results: Only 4 pts (27 %) maintained trough levels above the recommended minimum of 10 mg/l at the end of the first day (1 stage I, 3 stage F). Stage F pts were more likely to reach trough levels (50 % vs. 11 %) and AUC/MIC90 (100 % vs. 67 %). Conclusions: Current vancomycin dosing recommendations for critically ill patients on CVVH fail to achieve target trough levels on Day 1. The resulting AUC/MIC90 is sufficient only for pathogens with low MIC90. Boosted loading dose can increase efficacy for MIC90 = 1.0. More aggressive loading doses should be used in critically ill septic patients on CVVH to achieve adequate therapeutic exposure during this critical time period."@en . . . . "1212-7973" . "25" . "CZ - \u010Cesk\u00E1 republika" . . .