. "The importance of serum levels of selected biological parameters in the diagnosis, staging and prognosis of multiple myeloma" . "8"^^ . "57" . "multiple myeloma, monoclonal gammopathy, angiogenic cytokines, bone metabolism, International Staging System, prognosis"@en . "SK - Slovensk\u00E1 republika" . . . . "Petrov\u00E1, Pavla" . . "The importance of serum levels of selected biological parameters in the diagnosis, staging and prognosis of multiple myeloma" . . "Neoplasma" . . "9"^^ . . . . "[A6AB6719A9F8]" . . "263156" . "P(NR9489), P(NR9500), Z(MSM6198959205)" . . "0028-2685" . "2" . . . . . . "The study aimed at evaluating the relation of 7 parameters associated with the internal biological properties of myeloma cells and the bone marrow microenvironment to multiple myeloma (MM) stages, distinguishing its initial/asymptomatic phase from monoclonal gammopathy of undetermined significance (MGUS) and assessing their relation to myeloma prognosis. In the studied group comprising 286 individuals (89 MGUS and 179 MM patients), statistically significant differences (Mann-Whitney test) between MGUS and MM at the time of diagnosis were found in the serum levels of HGF (hepatocyte growth factor), VEGF (vascular endothelial growth factor), ICTP (intercellular ? carboxy-terminal telopeptide of type I collagen), PINP (procollagen type I N-terminal propeptide), OPG (osteoprotegerin) and syndecan-1/CD138, but not in Fas." . "\u0160\u010Dudla, Vlastimil" . . . "1"^^ . . "RIV/00098892:_____/10:#0000345" . "RIV/00098892:_____/10:#0000345!RIV13-MZ0-00098892" . "The importance of serum levels of selected biological parameters in the diagnosis, staging and prognosis of multiple myeloma"@en . "The study aimed at evaluating the relation of 7 parameters associated with the internal biological properties of myeloma cells and the bone marrow microenvironment to multiple myeloma (MM) stages, distinguishing its initial/asymptomatic phase from monoclonal gammopathy of undetermined significance (MGUS) and assessing their relation to myeloma prognosis. In the studied group comprising 286 individuals (89 MGUS and 179 MM patients), statistically significant differences (Mann-Whitney test) between MGUS and MM at the time of diagnosis were found in the serum levels of HGF (hepatocyte growth factor), VEGF (vascular endothelial growth factor), ICTP (intercellular ? carboxy-terminal telopeptide of type I collagen), PINP (procollagen type I N-terminal propeptide), OPG (osteoprotegerin) and syndecan-1/CD138, but not in Fas."@en . . "The importance of serum levels of selected biological parameters in the diagnosis, staging and prognosis of multiple myeloma"@en .