"Prospektivn\u011B jsme sledovali v\u00FDskyt perifern\u00EDch nervov\u00FDch komplikac\u00ED p\u0159i l\u00E9\u010Db\u011B statiny u souboru 42 pacient\u016F (23 \u017Een a 19 mu\u017E\u016F, pr\u016Fm\u011Brn\u00E9ho v\u011Bku 51,9 a 52,3 roku). Byla provedena elektrofyziologick\u00E1 vy\u0161et\u0159en\u00ED na nervech doln\u00EDch kon\u010Detin. Pod\u00E1vali jsme simvastatin v d\u00E1vce 20mg/den a pacienty jsme sledovali po dobu 24 m\u011Bs\u00EDc\u016F. Kontroln\u00ED elektrofyziologick\u00E9 n\u00E1lezy neprokazovaly p\u0159\u00EDtomnost perifern\u00ED neuropatie. Z\u00EDskan\u00E1 data byla analyzov\u00E1na metodou p\u00E1rov\u00E9ho t-testu a posouzena pomoc\u00ED regresn\u00ED anal\u00FDzy. Regresn\u00ED anal\u00FDza prok\u00E1zala, \u017Ee v \u010Dase se statisticky signifikantn\u011B zvy\u0161uj\u00ED hodnoty parametr\u016F pr\u016Fm\u011Brn\u00E9 latence F vln u n. peroneus a tak\u00E9 u n. tibialis. Studie ukazuje na to, \u017Ee dlouhodob\u00E1 l\u00E9\u010Dba hypolipidemiky m\u016F\u017Ee zp\u016Fsobovat klinicky n\u011Bm\u00E9, p\u0159esto elektrofyziologick\u00FDmi metodami zjistitelnou dysfunkci perifern\u00EDch nerv\u016F." . . "[D0D1911A9583]" . . "The peripheral nervous system complications with statin treatment was prospectively investigated in a group of 42 patients (23 females, 19 males, mean ages 51.9 and 52.3 years, respectively). Initial examinations included laboratory and electrophysiological measures (peroneal and tibial nerves: MNCV, CMAP, F-wave; superficial peroneal and sural nerves: SNCV, SNAP)., treatment with simvastatin 20mg daily was initiated. Patients were followed for 24 months. Electrophysiological examination of lower-limb peripheral nerves demonstrated statistically significant prolongation of F-wave mean latency on the peroneal and tibial nerves (p<0.0001). The study demonstrated that long-term treatment with statins may cause dysfunction of peripheral nerves"@en . "2" . "Treatment with statins and peripheral nervous system comlications: results of prospective clinical and neurophysiologic surveillance"@en . . "SK - Slovensk\u00E1 republika" . "2"^^ . "Prospektivn\u011B jsme sledovali v\u00FDskyt perifern\u00EDch nervov\u00FDch komplikac\u00ED p\u0159i l\u00E9\u010Db\u011B statiny u souboru 42 pacient\u016F (23 \u017Een a 19 mu\u017E\u016F, pr\u016Fm\u011Brn\u00E9ho v\u011Bku 51,9 a 52,3 roku). Byla provedena elektrofyziologick\u00E1 vy\u0161et\u0159en\u00ED na nervech doln\u00EDch kon\u010Detin. Pod\u00E1vali jsme simvastatin v d\u00E1vce 20mg/den a pacienty jsme sledovali po dobu 24 m\u011Bs\u00EDc\u016F. Kontroln\u00ED elektrofyziologick\u00E9 n\u00E1lezy neprokazovaly p\u0159\u00EDtomnost perifern\u00ED neuropatie. Z\u00EDskan\u00E1 data byla analyzov\u00E1na metodou p\u00E1rov\u00E9ho t-testu a posouzena pomoc\u00ED regresn\u00ED anal\u00FDzy. Regresn\u00ED anal\u00FDza prok\u00E1zala, \u017Ee v \u010Dase se statisticky signifikantn\u011B zvy\u0161uj\u00ED hodnoty parametr\u016F pr\u016Fm\u011Brn\u00E9 latence F vln u n. peroneus a tak\u00E9 u n. tibialis. Studie ukazuje na to, \u017Ee dlouhodob\u00E1 l\u00E9\u010Dba hypolipidemiky m\u016F\u017Ee zp\u016Fsobovat klinicky n\u011Bm\u00E9, p\u0159esto elektrofyziologick\u00FDmi metodami zjistitelnou dysfunkci perifern\u00EDch nerv\u016F."@cs . "Otruba, Pavel" . . . . "RIV/00098892:_____/08:#0000203!RIV12-MZ0-00098892" . "RIV/00098892:_____/08:#0000203" . . . "statins, polyneuropathy, electromyography"@en . "376474" . . "I, S" . "3"^^ . . . . . "3" . . "L\u00E9\u010Dba statiny a perifern\u00ED nervov\u00E9 komplikace: v\u00FDsledky prospektivn\u00EDho klinick\u00E9ho a neurofyziologick\u00E9ho sledov\u00E1n\u00ED" . "Treatment with statins and peripheral nervous system comlications: results of prospective clinical and neurophysiologic surveillance"@en . "L\u00E9\u010Dba statiny a perifern\u00ED nervov\u00E9 komplikace: v\u00FDsledky prospektivn\u00EDho klinick\u00E9ho a neurofyziologick\u00E9ho sledov\u00E1n\u00ED"@cs . "Ka\u0148ovsk\u00FD, Petr" . . "1336-8621" . "L\u00E9\u010Dba statiny a perifern\u00ED nervov\u00E9 komplikace: v\u00FDsledky prospektivn\u00EDho klinick\u00E9ho a neurofyziologick\u00E9ho sledov\u00E1n\u00ED"@cs . "Neurol\u00F3gia" . "1"^^ . "L\u00E9\u010Dba statiny a perifern\u00ED nervov\u00E9 komplikace: v\u00FDsledky prospektivn\u00EDho klinick\u00E9ho a neurofyziologick\u00E9ho sledov\u00E1n\u00ED" .