"Havl\u00ED\u010Dkov\u00E1, Martina" . . "D\u017Eupov\u00E1, Olga" . . "RIV/00064211:_____/12:#0000204!RIV14-MZ0-00064211" . "5"^^ . . "Mikroneutralizace v diagnostice ch\u0159ipkov\u00E9 infekce"@cs . "Serology plays an important role in the diagnosis of influenza, particularly in the detection of post-vaccination and post-infection antibodies. When considering the range of diagnostic options, the serological method should be selected depending on the circumstances \u2013 whether single or paired serum samples are tested, whether adequate patient medical history data are available, whether epidemiological links are suspected, and, in particular, to what purpose the result will be used (differential diagnosis, post-infection follow-up, post-vaccination monitoring, etc.). The virus neutralization assay is one of the most sensitive and most objective serological tests, but it is highly dependent on the reaction balance and quality of the virus used. Determining the protective titer is crucial for the routine practice. Based on our experiments, we concluded that the virus neutralizing antibody titers are up to eight times as high in comparison with the hemaglutination inhibition test (HIT) or complement fixation reaction (CFR), but the correlation varies and is significantly influenced by interindividual variation in anti-neuraminidase antibodies and those against some internal proteins of influenza virus. We assume that the protective titer in the virus neutralization assay will be not less than 1 : 80. The predictive value of the titers below 1 : 40 is questionable"@en . . . "Microneutralization assay in the diagnosis of influenza infection"@en . . "Limberkov\u00E1, R." . "150522" . . . . . . . . "S\u00E9rologick\u00E9 vy\u0161et\u0159en\u00ED hraje v diagnostice ch\u0159ipky d\u016Fle\u017Eitou roli, p\u0159edev\u0161\u00EDm v ur\u010Den\u00ED postvakcina\u010Dn\u00EDch a postinfek\u010Dn\u00EDch protil\u00E1tek. Vzhledem k r\u016Fzn\u00FDm diagnostick\u00FDm mo\u017Enostem je nutn\u00E9 metodiku s\u00E9rologick\u00E9ho vy\u0161et\u0159en\u00ED volit podle konkr\u00E9tn\u00EDch okolnost\u00ED \u2013 zda se jedn\u00E1 o p\u00E1rov\u00E9 s\u00E9rum \u010Di jednovzorek, zda je k dispozici adekv\u00E1tn\u00ED anamn\u00E9za pacienta a p\u0159\u00EDpadn\u00E9 epidemiologick\u00E9 souvislosti a p\u0159edev\u0161\u00EDm \u2013 jak\u00E9mu \u00FA\u010Delu bude v\u00FDsledek slou\u017Eit (diferenci\u00E1ln\u011Bdiagnostick\u00E1 rozvaha, postinfek\u010Dn\u00ED sledov\u00E1n\u00ED, postvakcina\u010Dn\u00ED zhodnocen\u00ED). Virusneutralizace p\u0159edstavuje jeden z nejcitliv\u011Bj\u0161\u00EDch a nejobjektivn\u011Bj\u0161\u00EDch s\u00E9rologick\u00FDch test\u016F, je v\u0161ak velmi z\u00E1visl\u00E1 na p\u0159esn\u00E9m vyv\u00E1\u017Een\u00ED reakce a kvalit\u011B viru, kter\u00FD je do reakce pou\u017Eit. Stanoven\u00ED protektivn\u00EDho titru je pro rutinn\u00ED praxi nezbytn\u00E9. V na\u0161em testovan\u00ED jsme do\u0161li k z\u00E1v\u011Bru, \u017Ee virusneutraliza\u010Dn\u00ED titry jsou v porovn\u00E1n\u00ED s HIT \u010Di KFR a\u017E osmin\u00E1sobn\u011B vy\u0161\u0161\u00ED, korelace v\u0161ak nen\u00ED nikterak pevn\u00E1 a je v\u00FDznamn\u011B ovlivn\u011Bn\u00E1 individu\u00E1ln\u00ED v\u00FD\u0161\u00ED protil\u00E1tek proti neuraminid\u00E1ze a n\u011Bkter\u00FDm vnit\u0159n\u00EDm protein\u016Fm. Auto\u0159i p\u0159edb\u011B\u017En\u011B uzav\u00EDraj\u00ED, \u017Ee v\u00FD\u0161e protektivn\u00EDho titru ve virusneutraliza\u010Dn\u00EDm testu bude nejm\u00E9n\u011B 1 : 80. Informativn\u00ED v\u00FDznam titr\u016F ni\u017E\u0161\u00EDch ne\u017E 1 : 40 je sporn\u00FD." . . "S\u00E9rologick\u00E9 vy\u0161et\u0159en\u00ED hraje v diagnostice ch\u0159ipky d\u016Fle\u017Eitou roli, p\u0159edev\u0161\u00EDm v ur\u010Den\u00ED postvakcina\u010Dn\u00EDch a postinfek\u010Dn\u00EDch protil\u00E1tek. Vzhledem k r\u016Fzn\u00FDm diagnostick\u00FDm mo\u017Enostem je nutn\u00E9 metodiku s\u00E9rologick\u00E9ho vy\u0161et\u0159en\u00ED volit podle konkr\u00E9tn\u00EDch okolnost\u00ED \u2013 zda se jedn\u00E1 o p\u00E1rov\u00E9 s\u00E9rum \u010Di jednovzorek, zda je k dispozici adekv\u00E1tn\u00ED anamn\u00E9za pacienta a p\u0159\u00EDpadn\u00E9 epidemiologick\u00E9 souvislosti a p\u0159edev\u0161\u00EDm \u2013 jak\u00E9mu \u00FA\u010Delu bude v\u00FDsledek slou\u017Eit (diferenci\u00E1ln\u011Bdiagnostick\u00E1 rozvaha, postinfek\u010Dn\u00ED sledov\u00E1n\u00ED, postvakcina\u010Dn\u00ED zhodnocen\u00ED). Virusneutralizace p\u0159edstavuje jeden z nejcitliv\u011Bj\u0161\u00EDch a nejobjektivn\u011Bj\u0161\u00EDch s\u00E9rologick\u00FDch test\u016F, je v\u0161ak velmi z\u00E1visl\u00E1 na p\u0159esn\u00E9m vyv\u00E1\u017Een\u00ED reakce a kvalit\u011B viru, kter\u00FD je do reakce pou\u017Eit. Stanoven\u00ED protektivn\u00EDho titru je pro rutinn\u00ED praxi nezbytn\u00E9. V na\u0161em testovan\u00ED jsme do\u0161li k z\u00E1v\u011Bru, \u017Ee virusneutraliza\u010Dn\u00ED titry jsou v porovn\u00E1n\u00ED s HIT \u010Di KFR a\u017E osmin\u00E1sobn\u011B vy\u0161\u0161\u00ED, korelace v\u0161ak nen\u00ED nikterak pevn\u00E1 a je v\u00FDznamn\u011B ovlivn\u011Bn\u00E1 individu\u00E1ln\u00ED v\u00FD\u0161\u00ED protil\u00E1tek proti neuraminid\u00E1ze a n\u011Bkter\u00FDm vnit\u0159n\u00EDm protein\u016Fm. Auto\u0159i p\u0159edb\u011B\u017En\u011B uzav\u00EDraj\u00ED, \u017Ee v\u00FD\u0161e protektivn\u00EDho titru ve virusneutraliza\u010Dn\u00EDm testu bude nejm\u00E9n\u011B 1 : 80. Informativn\u00ED v\u00FDznam titr\u016F ni\u017E\u0161\u00EDch ne\u017E 1 : 40 je sporn\u00FD."@cs . "CZ - \u010Cesk\u00E1 republika" . "Mikroneutralizace v diagnostice ch\u0159ipkov\u00E9 infekce" . "Microneutralization assay in the diagnosis of influenza infection"@en . "1210-7913" . "Ji\u0159incov\u00E1, H." . "RIV/00064211:_____/12:#0000204" . "protective titers; influenza virus; virus neutralization; serology"@en . "[3D9A42A824D9]" . "6"^^ . "Mikroneutralizace v diagnostice ch\u0159ipkov\u00E9 infekce"@cs . . . "2"^^ . . "61" . "P(NT12493)" . . "1-2" . "Mare\u0161ov\u00E1, Vilma" . "000325185100002" . "Mikroneutralizace v diagnostice ch\u0159ipkov\u00E9 infekce" . "Epidemiologie, infek\u010Dn\u00ED nemoci a klinick\u00E1 imunologie" .