"Syfilis je star\u00E9 onemocn\u011Bn\u00ED, jeho\u017E v\u00FDskyt v rozvinut\u00FDch zem\u00EDch ve druh\u00E9 polovin\u011B minul\u00E9ho stolet\u00ED do\u010Dasn\u011B poklesl, ale kter\u00E9 se op\u011Bt vrac\u00ED. V \u010Cesk\u00E9 republice byla minim\u00E1ln\u00ED incidence v roce 1990, od t\u00E9 doby u n\u00E1s vzrostl v\u00FDskyt syfilis v\u00EDce ne\u017E \u0161estkr\u00E1t. Zvl\u00E1\u0161t\u011B ohro\u017Eeni jsou homosexu\u00E1ln\u00ED mu\u017Ei, zejm\u00E9na s HIV infekc\u00ED, a toxikomani. K posti\u017Een\u00ED nervov\u00E9ho syst\u00E9mu m\u016F\u017Ee doj\u00EDt b\u011Bhem kter\u00E9hokoliv stadia syfilis; v sou\u010Dasn\u00E9 dob\u011B p\u0159evl\u00E1daj\u00ED \u010Dasn\u011Bj\u0161\u00ED formy neurosyfilis, pozdn\u00ED komplikace se vyskytuj\u00ED vz\u00E1cn\u011B. Diagn\u00F3za syfilis je zalo\u017Eena p\u0159edev\u0161\u00EDm na s\u00E9rologick\u00FDch testech. Ve skr\u00EDningu se pou\u017E\u00EDv\u00E1 kombinace metod nespecifick\u00FDch (netreponemov\u00FDch) a specifick\u00FDch (treponemov\u00FDch), pro konfirmaci se pou\u017E\u00EDvaj\u00ED testy specifick\u00E9. Klinick\u00FD obraz neurosyfilis je velmi pestr\u00FD a v diagnostice m\u00E1 z\u00E1kladn\u00ED v\u00FDznam komplexn\u00ED vy\u0161et\u0159en\u00ED likvoru v\u010Detn\u011B s\u00E9rologick\u00FDch test\u016F nespecifick\u00FDch a specifick\u00FDch. Diagn\u00F3za syfilis podl\u00E9h\u00E1 povinn\u00E9mu hl\u00E1\u0161en\u00ED a rovn\u011B\u017E l\u00E9\u010Dba je ze z\u00E1kona povinn\u00E1. Z\u00E1kladn\u00EDm l\u00E9kem neurosyfilis je benzylpenicilin, ostatn\u00ED antibiotika jsou m\u00E9n\u011B \u00FA\u010Dinn\u00E1. Po ukon\u010Den\u00ED l\u00E9\u010Dby syfilis z\u016Fst\u00E1vaj\u00ED v\u0161ichni pacienti v dlouhodob\u00E9 dispenzarizaci dermatovenerologa. Vzhledem ke slo\u017Eitosti klinick\u00E9 i laboratorn\u00ED problematiky neurosyfilis je pro stanoven\u00ED spr\u00E1vn\u00E9 diagn\u00F3zy a rozhodnut\u00ED o optim\u00E1ln\u00ED terapii v\u017Edy nutn\u00E1 \u00FAzk\u00E1 spolupr\u00E1ce neurologa, dermatovenerologa a laboratorn\u00EDho specialisty." . . "1210-7859" . "75" . "Syphilis; Neurosyphilis; Cerebrospinal-fluid; Penicillin; Pregnancy; Adults; Serum; Model"@en . . . "Hecogov\u00E1, Jana" . "Syphilis is an old disease and its incidence in developed countries decreased in the second half of the last century. However, at present, syphilis is on increase again. Since 1990, when the incidence was lowest, the incidence of syphilis in the Czech Republic increased more than six-fold with HIV+ homosexual men and drug addicts being the highest risk groups. The CNS can be involved at any stage of syphilis; early forms of neurosyphilis currently predominate, whereas late complications rarely occur. The diagnosis of syphilis is based on serological tests. A combination of both nonspecific (nontreponemal) and specific (treponemal) methods are used for screening; specific tests are used for confirmation. Clinical symptomatology of neurosyphilis is very variable and comprehensive analysis of cerebrospinal fluid including specific and nonspecific serologic tests plays a crucial role in diagnostics. Legislation requires all cases of diagnosed syphilis to be reported and treated. Neurosyphilis is treated with benzylpenicillin as a standard, other antibiotics are less effective. After completing the therapy, all patients are followed up long-term by a venereologist. Considering the complex clinical and laboratory symptomatology of neurosyphilis, correct diagnosis and optimal therapeutic decision requires close cooperation between a neurologist, venereologist and laboratory specialist."@en . . "Neurosyphilis"@cs . "Ko\u017Ener, Pavel" . . . "\u010Cesk\u00E1 a slovensk\u00E1 neurologie a neurochirurgie" . "RIV/00064211:_____/12:#0000161" . . . "CZ - \u010Cesk\u00E1 republika" . "153906" . . "Neurosyphilis"@cs . . "6"^^ . . "\u010Cern\u00FD, Rudolf" . "2"^^ . "Neurosyfilis"@en . "Va\u0148ousov\u00E1, Daniela" . "Neurosyphilis" . . "Machala, Ladislav" . . "Neurosyfilis"@en . "[437175B1010C]" . "Lis\u00FD, Ji\u0159\u00ED" . "8"^^ . "000305819900004" . . . "Neurosyphilis" . . "3" . . "V" . . "Syfilis je star\u00E9 onemocn\u011Bn\u00ED, jeho\u017E v\u00FDskyt v rozvinut\u00FDch zem\u00EDch ve druh\u00E9 polovin\u011B minul\u00E9ho stolet\u00ED do\u010Dasn\u011B poklesl, ale kter\u00E9 se op\u011Bt vrac\u00ED. V \u010Cesk\u00E9 republice byla minim\u00E1ln\u00ED incidence v roce 1990, od t\u00E9 doby u n\u00E1s vzrostl v\u00FDskyt syfilis v\u00EDce ne\u017E \u0161estkr\u00E1t. Zvl\u00E1\u0161t\u011B ohro\u017Eeni jsou homosexu\u00E1ln\u00ED mu\u017Ei, zejm\u00E9na s HIV infekc\u00ED, a toxikomani. K posti\u017Een\u00ED nervov\u00E9ho syst\u00E9mu m\u016F\u017Ee doj\u00EDt b\u011Bhem kter\u00E9hokoliv stadia syfilis; v sou\u010Dasn\u00E9 dob\u011B p\u0159evl\u00E1daj\u00ED \u010Dasn\u011Bj\u0161\u00ED formy neurosyfilis, pozdn\u00ED komplikace se vyskytuj\u00ED vz\u00E1cn\u011B. Diagn\u00F3za syfilis je zalo\u017Eena p\u0159edev\u0161\u00EDm na s\u00E9rologick\u00FDch testech. Ve skr\u00EDningu se pou\u017E\u00EDv\u00E1 kombinace metod nespecifick\u00FDch (netreponemov\u00FDch) a specifick\u00FDch (treponemov\u00FDch), pro konfirmaci se pou\u017E\u00EDvaj\u00ED testy specifick\u00E9. Klinick\u00FD obraz neurosyfilis je velmi pestr\u00FD a v diagnostice m\u00E1 z\u00E1kladn\u00ED v\u00FDznam komplexn\u00ED vy\u0161et\u0159en\u00ED likvoru v\u010Detn\u011B s\u00E9rologick\u00FDch test\u016F nespecifick\u00FDch a specifick\u00FDch. Diagn\u00F3za syfilis podl\u00E9h\u00E1 povinn\u00E9mu hl\u00E1\u0161en\u00ED a rovn\u011B\u017E l\u00E9\u010Dba je ze z\u00E1kona povinn\u00E1. Z\u00E1kladn\u00EDm l\u00E9kem neurosyfilis je benzylpenicilin, ostatn\u00ED antibiotika jsou m\u00E9n\u011B \u00FA\u010Dinn\u00E1. Po ukon\u010Den\u00ED l\u00E9\u010Dby syfilis z\u016Fst\u00E1vaj\u00ED v\u0161ichni pacienti v dlouhodob\u00E9 dispenzarizaci dermatovenerologa. Vzhledem ke slo\u017Eitosti klinick\u00E9 i laboratorn\u00ED problematiky neurosyfilis je pro stanoven\u00ED spr\u00E1vn\u00E9 diagn\u00F3zy a rozhodnut\u00ED o optim\u00E1ln\u00ED terapii v\u017Edy nutn\u00E1 \u00FAzk\u00E1 spolupr\u00E1ce neurologa, dermatovenerologa a laboratorn\u00EDho specialisty."@cs . "Z\u00E1koutsk\u00E1, Hana" . "RIV/00064211:_____/12:#0000161!RIV14-MZ0-00064211" . . "Jilich, David" . . .