. . "Melanin production is the primary mechanism protecting human skin against the UV light-induced damage. The transcription factor MITF, which has been reported to activate more than 25 genes in pigment cells, has emerged as an essential regulator not only for melanocyte development, proliferation and survival, but also for the expression of enzymes and structural proteins ensuring the production of melanin. Here, we outline the mechanisms of transcriptional regulation of genes associated with the biosynthesis of melanin in melanocytes and melanoma cells. MITF is crucial in this process, while several other factors seem to have only an auxiliary role to play under specific circumstances." . "7" . . "Borovansk\u00FD, Jan" . . "11"^^ . "Experimental dermatology" . "0906-6705" . . "DK - D\u00E1nsk\u00E9 kr\u00E1lovstv\u00ED" . "%22Transcription physiology%22 of pigment formation in melanocytes: central role of MITF." . . "RIV/00064211:_____/10:#0000066" . "RIV/00064211:_____/10:#0000066!RIV11-MZ0-00064211" . . "1"^^ . . "%22Transcription physiology%22 of pigment formation in melanocytes: central role of MITF."@en . "2"^^ . . . "[9A495ABD39D7]" . . . . "%22Transcription physiology%22 of pigment formation in melanocytes: central role of MITF." . "Vachtenheim, Ji\u0159\u00ED" . . . . "%22Transcription physiology%22 of pigment formation in melanocytes: central role of MITF."@en . . "melanin; melanoma; microphthalmia; microphthalmia-associated transcription factor; pigmentation"@en . . "293275" . . . . "Melanin production is the primary mechanism protecting human skin against the UV light-induced damage. The transcription factor MITF, which has been reported to activate more than 25 genes in pigment cells, has emerged as an essential regulator not only for melanocyte development, proliferation and survival, but also for the expression of enzymes and structural proteins ensuring the production of melanin. Here, we outline the mechanisms of transcriptional regulation of genes associated with the biosynthesis of melanin in melanocytes and melanoma cells. MITF is crucial in this process, while several other factors seem to have only an auxiliary role to play under specific circumstances."@en . "19" . "I, P(NR9319), S, Z(MSM0021620808)" .