"Repression of the melanocyte-specific promoter of the microphthalmia-associated transcription factor by the adenoviral E1A 12S oncoprotein"@en . . "Represe melanocytov\u011B specifick\u00E9ho promotoru microphthalmia-asociovan\u00E9ho transkrip\u010Dn\u00EDho faktoru adenovirov\u00FDm oncoproteinem E1A 12S"@cs . . "Micropthtalmia transcription faktor (MITF) is crucial for the development of the melanocyte lineage and is overexpressed in malignant melanomas. The E1A protein is known to also exert an antitumor activity, which is associated with its transcription repression function and the ability to induce apoptosis and is a potential antimelanoma agent. We tested a direct repression of the melanocyte-specific MITF promoter by E1A and its mutants and we found that the extreme N-terminus and conserved region 1 are required for repression." . . "FOLIA BIOLOGICA" . "Repression of the melanocyte-specific promoter of the microphthalmia-associated transcription factor by the adenoviral E1A 12S oncoprotein" . "E1A;microphthalmia;MITF;melanoma;repression;0"@en . "Represe melanocytov\u011B specifick\u00E9ho promotoru microphthalmia-asociovan\u00E9ho transkrip\u010Dn\u00EDho faktoru adenovirov\u00FDm oncoproteinem E1A 12S"@cs . . "Z(MZ00000064211)" . "RIV/00064211:_____/04:00011449" . . "Microphthalmia transkrip\u010Dn\u00ED faktor (MITF) m\u00E1 rozhoduj\u00EDc\u00ED vliv ve v\u00FDvoji melanocytov\u00FDch lini\u00ED a u malign\u00EDch melanom\u016F je nadexprimovan\u00FD. Protein E1A je zn\u00E1m\u00FD mimo jin\u00E9 antitumorovou aktivitou, kter\u00E1 je spojen\u00E1 s jeho transkrip\u010Dn\u011B represorovou funkc\u00ED a schopnost\u00ED indukovat apopt\u00F3zu a m\u00E1 potenci\u00E1ln\u011B antimelanomov\u00E9 \u00FA\u010Dinky. Testovali jsme p\u0159\u00EDmou represi MITF-promotoru, specifick\u00E9ho pro melanocyty, pomoc\u00ED E1A a jeho mutant. Zjistili jsme, \u017Ee N-koncov\u00E1 oblast a konzervovan\u00E1 dom\u00E9na 1 jsou nezbytn\u00E9 pro tuto represi."@cs . "Repression of the melanocyte-specific promoter of the microphthalmia-associated transcription factor by the adenoviral E1A 12S oncoprotein" . . "159-166" . "Vachtenheim, Ji\u0159\u00ED" . . . "CZ - \u010Cesk\u00E1 republika" . "0015-5500" . . . "[A721CF32B818]" . . "Repression of the melanocyte-specific promoter of the microphthalmia-associated transcription factor by the adenoviral E1A 12S oncoprotein"@en . "neuveden" . "Drdov\u00E1, Blanka" . "584357" . . "2"^^ . . "50" . "2"^^ . "8"^^ . . . . . "Micropthtalmia transcription faktor (MITF) is crucial for the development of the melanocyte lineage and is overexpressed in malignant melanomas. The E1A protein is known to also exert an antitumor activity, which is associated with its transcription repression function and the ability to induce apoptosis and is a potential antimelanoma agent. We tested a direct repression of the melanocyte-specific MITF promoter by E1A and its mutants and we found that the extreme N-terminus and conserved region 1 are required for repression."@en . "RIV/00064211:_____/04:00011449!RIV/2005/MZ0/L10005/N" . .