"97053" . "V kazuistice prezentujeme p\u0159\u00EDpad velmi vz\u00E1cn\u00E9ho syst\u00E9mov\u00E9ho onemocn\u011Bn\u00ED p-ANCA pozitivn\u00ED nekrotizuj\u00EDc\u00ED vaskulitidy u 11let\u00E9ho d\u00EDt\u011Bte. Jedn\u00E1 se o polyangiitis microscopica, kter\u00E1 pat\u0159\u00ED do skupiny ANCA vaskulitid. Onemocn\u011Bn\u00ED je vedle p\u0159\u00EDtomnosti nespecifick\u00FDch p\u0159\u00EDznak\u016F charakterizovan\u00E9 org\u00E1nov\u00FDm posti\u017Een\u00EDm nejen ledvin s typick\u00FDm histologick\u00FDm obrazem, ale i plic. Sou\u010Dasn\u00E9 posti\u017Een\u00ED plic (tzv. pulmoren\u00E1ln\u00ED syndrom) je prognosticky velmi z\u00E1va\u017En\u00E9. V l\u00E9\u010Db\u011B progresivn\u00EDho onemocn\u011Bn\u00ED se nej\u010Dast\u011Bji pou\u017E\u00EDv\u00E1 imunosuprese kortikoidy (prednison, metylprednisolon) nej\u010Dast\u011Bji v kombinaci s cytotoxick\u00FDmi l\u00E9ky (cyklofosfamid, azathioprin). Plazmafer\u00E9za je indikovan\u00E1 v akutn\u00ED f\u00E1zi a p\u0159i pulmoren\u00E1ln\u00EDm syndromu. Kombinace rituximab+kortikoidy byla v roce 2011 schv\u00E1lena FDA v l\u00E9\u010Db\u011B dosp\u011Bl\u00FDch pacient\u016F. L\u00E9\u010Dba je dlouhodob\u00E1 vzhledem k \u010Dast\u00FDm relaps\u016Fm onemocn\u011Bn\u00ED."@cs . "I" . "6"^^ . "Zieg, Jakub" . "Polyangiitis microscopica - vz\u00E1cn\u00E1 nekrotizuj\u00EDc\u00ED vaskulitida"@cs . . "RIV/00064203:_____/13:10193981" . . "Seeman, Tom\u00E1\u0161" . "2" . . "Polyangiitis microscopica - vz\u00E1cn\u00E1 nekrotizuj\u00EDc\u00ED vaskulitida" . "10" . "We present a very rare case of systemic disease p-ANCA positive necrotizing vasculitis in an 11-year-old child. Polyangiitis microscopica belongs to the group of ANCA vasculitis. The disease is characterized beside presence of non-specific symptoms with typical kidney involvement based on characteristic histological finding. Coincident lung and kidney involvement, the so called pulmorenal syndrome has much more poor prognosis. The most common treatment of progressive forms of the disease is based on immunosuppressants: corticosteroids (prednisolon, methylprednisolon) in combination with cytotoxic drugs (cyclophosphamide, azathioprine). Plasmapheresis is indicated in an acute progressive phase of the disease resistant to the immunosuppression and in case of pulmorenal syndrome. Combination of rituximab+corticosteroids has been proved by FDA in 2011 in the treatment in adulthood. The treatment should be long-lasting because of frequent relapses of the disease."@en . "4"^^ . "Polyangiitis microscopica - vz\u00E1cn\u00E1 nekrotizuj\u00EDc\u00ED vaskulitida"@cs . . "1802-0518" . "Stejskal, Josef" . "RIV/00064203:_____/13:10193981!RIV14-MZ0-00064203" . "Du\u0161ek, Ji\u0159\u00ED" . "Janda, Jan" . . . . . "[ABDA25799278]" . "\u0160im\u00E1nkov\u00E1, Nad\u011B\u017Eda" . . "Polyangiitis microscopica"@en . . "Vondr\u00E1k, Karel" . . . . . . "Polyangiitis microscopica - a rare necrotizing vasculitis"@en . "CZ - \u010Cesk\u00E1 republika" . "7"^^ . . "V kazuistice prezentujeme p\u0159\u00EDpad velmi vz\u00E1cn\u00E9ho syst\u00E9mov\u00E9ho onemocn\u011Bn\u00ED p-ANCA pozitivn\u00ED nekrotizuj\u00EDc\u00ED vaskulitidy u 11let\u00E9ho d\u00EDt\u011Bte. Jedn\u00E1 se o polyangiitis microscopica, kter\u00E1 pat\u0159\u00ED do skupiny ANCA vaskulitid. Onemocn\u011Bn\u00ED je vedle p\u0159\u00EDtomnosti nespecifick\u00FDch p\u0159\u00EDznak\u016F charakterizovan\u00E9 org\u00E1nov\u00FDm posti\u017Een\u00EDm nejen ledvin s typick\u00FDm histologick\u00FDm obrazem, ale i plic. Sou\u010Dasn\u00E9 posti\u017Een\u00ED plic (tzv. pulmoren\u00E1ln\u00ED syndrom) je prognosticky velmi z\u00E1va\u017En\u00E9. V l\u00E9\u010Db\u011B progresivn\u00EDho onemocn\u011Bn\u00ED se nej\u010Dast\u011Bji pou\u017E\u00EDv\u00E1 imunosuprese kortikoidy (prednison, metylprednisolon) nej\u010Dast\u011Bji v kombinaci s cytotoxick\u00FDmi l\u00E9ky (cyklofosfamid, azathioprin). Plazmafer\u00E9za je indikovan\u00E1 v akutn\u00ED f\u00E1zi a p\u0159i pulmoren\u00E1ln\u00EDm syndromu. Kombinace rituximab+kortikoidy byla v roce 2011 schv\u00E1lena FDA v l\u00E9\u010Db\u011B dosp\u011Bl\u00FDch pacient\u016F. L\u00E9\u010Dba je dlouhodob\u00E1 vzhledem k \u010Dast\u00FDm relaps\u016Fm onemocn\u011Bn\u00ED." . "Polyangiitis microscopica - a rare necrotizing vasculitis"@en . "Polyangiitis microscopica - vz\u00E1cn\u00E1 nekrotizuj\u00EDc\u00ED vaskulitida" . "Kazuistiky v alergologii, pneumologii a ORL" . . .