"126780" . "Podgoreanu, E." . "Pavicevic, S." . "Characteristics and Outcomes of Children with Primary Oxalosis Requiring Renal Replacement Therapy"@en . "RIV/00064203:_____/12:8589!RIV13-MZ0-00064203" . "Szab\u00F3, L." . "Puretic, Z." . "7" . "[C536DCC7B398]" . "3" . . "Leozappa, G." . "8"^^ . "Hoeck, K." . "Podracka, L." . "RIV/00064203:_____/12:8589" . . "Baiko, S." . "Espinosa, L." . "Background and objectives Primary hyperoxaluria (PH) as a cause of ESRD in children is believed to have poor outcomes. Data on management and outcomes of these children remain scarce. Design, setting, participants, & measurements This study included patients aged <19 years who started renal replacement therapy (RRT) between 1979 and 2009 from 31 countries providing data to a large European registry. Results Of 9247 incident patients receiving RRT, 100 patients had PH. PH children were significantly younger than non-PH children at the start of RRT. The median age at RRT of PH children decreased from 9.8 years in 1979-1989 to 1.5 years in 2000-2009. Survival was 86%, 79%, and 76% among PH patients at 1, 3, and 5 years after the start of RRT, compared with 97%, 94%, and 92% in non-PH patients, resulting in a three-fold increased risk of death over non-PH patients. PH and non-PH patient survival improved over time. Sixty-eight PH children received a first kidney (n=13) or liver-kidney transplantation (n=55). Although the comparison was hampered by the lower number of kidney transplantations primarily derived from the earlier era of RRT, kidney graft survival in PH patients was 82%, 79%, and 76% at 1, 3, and 5 years for liver-kidney transplantation and 46%, 28%, and 14% at 1, 3, and 5 years for kidney transplantation alone, compared with 95%, 90%, and 85% in non-PH patients. Conclusions The outcomes of PH children with ESRD are still poorer than in non-PH children but have substantially improved over time."@en . "Sukalo, A." . "Seeman, Tom\u00E1\u0161" . "Reusz, G." . "Heaf, J." . "1555-9041" . . "Zagozdzon, I." . "T\u00FAri, S." . "Grottes, JM" . "Kolvek, G." . "Spasojevic-Dimitrijeva, B." . "2"^^ . "Zurowska, A." . "Vondr\u00E1k, Karel" . "Oberbauer, R." . . "I" . . "Bikbov, BT" . . "Mircescu, G." . "Mencarelli, F." . "Verrina, E." . "Novljan, G." . "Afonso, C." . "Couchoud, C." . "Leivestad, T." . "000301222100014" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Brackman, D." . "Garneata, L." . . "Szab\u00F3, T." . "Gr\u00F6nhagen-Riska, C." . "Puteo, F." . . . "Scholz, C." . "Clinical Journal of the American Society of Nephrology" . "Pokrajac, D." . . "Batinic, D." . "Collart, F." . . . "89"^^ . "Roussinov, D." . "Mignot, L." . "Molchanova, E. A." . "Groothoff, JW" . "Sahpazova, E." . "Kramar, R." . . "Hulton, S. A." . "J\u00E4ger, KJ" . "Toots, U." . . "Characteristics and Outcomes of Children with Primary Oxalosis Requiring Renal Replacement Therapy" . "Minale, B." . "Schaefer, F." . "Gersdorf, G." . "http://dx.doi.org/10.2215/CJN.07430711" . "Characteristics and Outcomes of Children with Primary Oxalosis Requiring Renal Replacement Therapy" . . "Jankauskiene, A." . "Paripovic, D." . "Battelino, N." . "Stralen, KJ" . "Shitza, D." . . "Finne, P." . "Gianoglio, B." . "\u2026" . "Cerkauskiene, R." . "Mota, C." . "Lombaerts, R." . "primary hyperoxaluria type-1; liver-kidney transplantation; allograft survival; united-states; registry; growth; experience; mutation; infants; disease"@en . "Background and objectives Primary hyperoxaluria (PH) as a cause of ESRD in children is believed to have poor outcomes. Data on management and outcomes of these children remain scarce. Design, setting, participants, & measurements This study included patients aged <19 years who started renal replacement therapy (RRT) between 1979 and 2009 from 31 countries providing data to a large European registry. Results Of 9247 incident patients receiving RRT, 100 patients had PH. PH children were significantly younger than non-PH children at the start of RRT. The median age at RRT of PH children decreased from 9.8 years in 1979-1989 to 1.5 years in 2000-2009. Survival was 86%, 79%, and 76% among PH patients at 1, 3, and 5 years after the start of RRT, compared with 97%, 94%, and 92% in non-PH patients, resulting in a three-fold increased risk of death over non-PH patients. PH and non-PH patient survival improved over time. Sixty-eight PH children received a first kidney (n=13) or liver-kidney transplantation (n=55). Although the comparison was hampered by the lower number of kidney transplantations primarily derived from the earlier era of RRT, kidney graft survival in PH patients was 82%, 79%, and 76% at 1, 3, and 5 years for liver-kidney transplantation and 46%, 28%, and 14% at 1, 3, and 5 years for kidney transplantation alone, compared with 95%, 90%, and 85% in non-PH patients. Conclusions The outcomes of PH children with ESRD are still poorer than in non-PH children but have substantially improved over time." . "Almeida, M." . "Buturovic-Ponikvar, J." . "Gafencu, M." . "Cochat, P." . . "Niaudet, P." . "Holmberg, C." . . . "Harambat, J." . . "Kostic, M." . . "Ioannidis, G." . . "Tomilina, NA" . "Peco-Antic, A." . "Characteristics and Outcomes of Children with Primary Oxalosis Requiring Renal Replacement Therapy"@en . .