. . . "CZ - \u010Cesk\u00E1 republika" . "Specifick\u00E1 alergenov\u00E1 imunoterapie a autoimunitn\u00ED onemocn\u011Bn\u00ED"@cs . . "Allergen-specific immunotherapy is the curative method of treatment for allergic diseases and it has been used for 100 years. New researches in immune intervention include targeting of molecular mechanisms of allergen specific tolerance. The mechanisms of action of allergen-specific immunotherapy include modulation of T and B cell responses and related antibody isotypes especially IgE and IgG4. It has an influence on migration of eosinophils, basophils and mast cells to tissues as well as release of their mediators. Regulatory T (Treg) cells have been indentified as key regulators of immunologic processes in peripheral tolerance to allergens. Skewing of allergen-specific effector T cells to a regulatory phenotype apperas as a key event in the development of healthy immune response to allergens. If the mechanisms of action of SIT include such changes, it is not reason of increase the risk of autoimmune disorders."@en . "Vernerov\u00E1, Eva" . "[F1E687903E9A]" . . . "3"^^ . "RIV/00064203:_____/12:8385" . . "Specifick\u00E1 alergenov\u00E1 imunoterapie a autoimunitn\u00ED onemocn\u011Bn\u00ED" . "RIV/00064203:_____/12:8385!RIV13-MZ0-00064203" . "http://www.tigis.cz/images/stories/Alergie/2012/1_2012/12_vernerova_Z.pdf" . . . . "14" . "Alergie" . . "Specifick\u00E1 alergenov\u00E1 imunoterapie a autoimunitn\u00ED onemocn\u011Bn\u00ED"@cs . "allergen-specific immunotherapy; regulatory T cells; immune tolerance; Autoimmune disorders"@en . . . "Specifick\u00E1 alergenov\u00E1 imunoterapie (SIT) je l\u00E9\u010Debn\u00FD postup pou\u017E\u00EDvan\u00FD v sou\u010Dasn\u00E9 dob\u011B ji\u017E 100 let. Teprve v\u00FDzkumy z posledn\u00ED doby v\u0161ak objas\u0148uj\u00ED n\u011Bkter\u00E9 molekul\u00E1rn\u00ED mechanizmy, kter\u00E9 se uplat\u0148uj\u00ED p\u0159i nastolen\u00ED tolerance ke specifick\u00FDm alergen\u016Fm. P\u016Fsoben\u00ED SIT zahrnuje ovlivn\u011Bn\u00ED T- i B-bun\u011B\u010Dn\u00E9 odpov\u011Bdi a tomu odpov\u00EDdaj\u00EDc\u00ED zm\u011Bny hladin jednotliv\u00FDch izotyp\u016F imunoglobulin\u016F, zejm\u00E9na IgE a IgG4. V pr\u016Fb\u011Bhu SIT je ovlivn\u011Bna t\u00E9\u017E migrace eozinofil\u016F, bazofil\u016F a \u017E\u00EDrn\u00FDch bun\u011Bk, stejn\u011B jako jejich cytokinov\u00E9 spektrum. Kl\u00ED\u010Dem k realizaci tohoto procesu jsou z\u0159ejm\u011B T-regula\u010Dn\u00ED bu\u0148ky (Treg). P\u0159esmyk alergen specifick\u00FDch efektorov\u00FDch T-lymfocyt\u016F k fenotypu Treg se jev\u00ED pro rozvoj fyziologick\u00E9 imunitn\u00ED odpov\u011Bdi na kontakt s alergenem jako zcela z\u00E1sadn\u00ED. Pokud v\u0161ak SIT p\u016Fsob\u00ED skute\u010Dn\u011B t\u00EDmto mechanizmem, nem\u011Bla by riziko autoimunity zvy\u0161ovat." . "1212-3536" . . "Allergen specific immunotherapy and autoimmune disorders"@en . "1" . "170269" . . "Specifick\u00E1 alergenov\u00E1 imunoterapie (SIT) je l\u00E9\u010Debn\u00FD postup pou\u017E\u00EDvan\u00FD v sou\u010Dasn\u00E9 dob\u011B ji\u017E 100 let. Teprve v\u00FDzkumy z posledn\u00ED doby v\u0161ak objas\u0148uj\u00ED n\u011Bkter\u00E9 molekul\u00E1rn\u00ED mechanizmy, kter\u00E9 se uplat\u0148uj\u00ED p\u0159i nastolen\u00ED tolerance ke specifick\u00FDm alergen\u016Fm. P\u016Fsoben\u00ED SIT zahrnuje ovlivn\u011Bn\u00ED T- i B-bun\u011B\u010Dn\u00E9 odpov\u011Bdi a tomu odpov\u00EDdaj\u00EDc\u00ED zm\u011Bny hladin jednotliv\u00FDch izotyp\u016F imunoglobulin\u016F, zejm\u00E9na IgE a IgG4. V pr\u016Fb\u011Bhu SIT je ovlivn\u011Bna t\u00E9\u017E migrace eozinofil\u016F, bazofil\u016F a \u017E\u00EDrn\u00FDch bun\u011Bk, stejn\u011B jako jejich cytokinov\u00E9 spektrum. Kl\u00ED\u010Dem k realizaci tohoto procesu jsou z\u0159ejm\u011B T-regula\u010Dn\u00ED bu\u0148ky (Treg). P\u0159esmyk alergen specifick\u00FDch efektorov\u00FDch T-lymfocyt\u016F k fenotypu Treg se jev\u00ED pro rozvoj fyziologick\u00E9 imunitn\u00ED odpov\u011Bdi na kontakt s alergenem jako zcela z\u00E1sadn\u00ED. Pokud v\u0161ak SIT p\u016Fsob\u00ED skute\u010Dn\u011B t\u00EDmto mechanizmem, nem\u011Bla by riziko autoimunity zvy\u0161ovat."@cs . "Specifick\u00E1 alergenov\u00E1 imunoterapie a autoimunitn\u00ED onemocn\u011Bn\u00ED" . "1"^^ . "I" . "Allergen specific immunotherapy and autoimmune disorders"@en . . "1"^^ .