"RIV/00064203:_____/12:7983!RIV13-MZ0-00064203" . "Healy, CM" . "Lagiou, A." . "aspirin use; epidemiology; gastroesophageal reflux; medical history; medication use; upper aerodigestive tract cancer; nonsteroidal antiinflammatory drugs; oral-cancer; human-papillomavirus; risk-factors; esophageal; aspirin; head"@en . "Agudo, A." . "000302298000035" . . "Thakker, NS" . . "I, R" . "Slamova, A." . "Thomson, P." . . "8"^^ . "Simonato, L." . "Talamini, R." . . "McCartan, BE" . "Castellsague, X." . . "166025" . "29"^^ . . "4" . "Macfarlane, GJ" . "RIV/00064203:_____/12:7983" . . "Annals of Oncology" . "Pohlabeln, H." . "Benhamou, S." . . "Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: the ARCAGE study" . . "Marron, M." . "Znaor, A." . "Abstract: Background: The study aimed to investigate the role of medical history (skin warts, Candida albicans, herpetic lesions, heartburn, regurgitation) and medication use (for heartburn; for regurgitation; aspirin) in the aetiology of upper aerodigestive tract (UADT) cancer. Methods: A multicentre (10 European countries) case-control study [Alcohol-Related CAncers and GEnetic susceptibility (ARCAGE) project]. Results: There were 1779 cases of UADT cancer and 1993 controls. History of warts or C. albicans infection was associated with a reduced risk [odds ratio (OR) 0.80, 95% confidence interval (CI) 0.68-0.94 and OR 0.73, 95% CI 0.60-0.89, respectively] but there was no association with herpetic lesions, heartburn, regurgitation or medication for related symptoms. Regurgitation was associated with an increased risk for cancer of the oesophagus (OR 1.47, 95% CI 0.98-2.21). Regular aspirin use was not associated with risk of UADT cancer overall but was associated with a reduced risk for cancer of oesophagus (OR 0.51, 95% CI 0.28-0.96), hypopharynx (OR 0.53, 95% CI 0.28-1.02) and larynx (OR 0.74, 95% CI 0.54-1.01). Conclusions: A history of some infections appears to be a marker for decreased risk of UADT cancer. The role of medical history and medication use varied by UADT subsites with aspirin use associated with a decreased risk of oesophageal cancer and suggestive of a decreased risk of hypopharyngeal and laryngeal cancers." . . "Abstract: Background: The study aimed to investigate the role of medical history (skin warts, Candida albicans, herpetic lesions, heartburn, regurgitation) and medication use (for heartburn; for regurgitation; aspirin) in the aetiology of upper aerodigestive tract (UADT) cancer. Methods: A multicentre (10 European countries) case-control study [Alcohol-Related CAncers and GEnetic susceptibility (ARCAGE) project]. Results: There were 1779 cases of UADT cancer and 1993 controls. History of warts or C. albicans infection was associated with a reduced risk [odds ratio (OR) 0.80, 95% confidence interval (CI) 0.68-0.94 and OR 0.73, 95% CI 0.60-0.89, respectively] but there was no association with herpetic lesions, heartburn, regurgitation or medication for related symptoms. Regurgitation was associated with an increased risk for cancer of the oesophagus (OR 1.47, 95% CI 0.98-2.21). Regular aspirin use was not associated with risk of UADT cancer overall but was associated with a reduced risk for cancer of oesophagus (OR 0.51, 95% CI 0.28-0.96), hypopharynx (OR 0.53, 95% CI 0.28-1.02) and larynx (OR 0.74, 95% CI 0.54-1.01). Conclusions: A history of some infections appears to be a marker for decreased risk of UADT cancer. The role of medical history and medication use varied by UADT subsites with aspirin use associated with a decreased risk of oesophageal cancer and suggestive of a decreased risk of hypopharyngeal and laryngeal cancers."@en . . . "[D1C95BF79535]" . "Sloan, P." . . . "Brennan, P." . . . "Barzan, L." . "0923-7534" . "Kjaerheim, K." . "Ahrens, W." . "Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: the ARCAGE study" . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . . . "1"^^ . . "Richiardi, L." . "Macfarlane, TV" . . "Canova, C." . "Lagiou, P." . . "Bouchardy, C." . "Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: the ARCAGE study"@en . "Plz\u00E1k, Jan" . "Merletti, F." . "23" . . "http://dx.doi.org/10.1093/annonc/mdr335" . . . "Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: the ARCAGE study"@en . "Conway, DI" . "McKinney, P. A." .