. "Hobstov\u00E1, Ji\u0159ina" . "Za posledn\u00EDch 15 let zm\u011Bnil rychl\u00FD pokrok ve v\u00FDvoji virostatik chronick\u00E9 virov\u00E9 hepatitidy z kauz\u00E1ln\u011B nel\u00E9\u010Diteln\u00FDch onemocn\u011Bn\u00ED na nemoci, kter\u00E9 lze u cel\u00E9 \u0159ady pacient\u016F l\u00E9\u010Dit a vyl\u00E9\u010Dit. L\u00E9\u010Dba je v\u0161ak dlouhodob\u00E1 a velmi n\u00E1kladn\u00E1. I proto je d\u016Fle\u017Eit\u00E1 spr\u00E1vn\u00E1 diagn\u00F3za s p\u0159esnou stratifikac\u00ED onemocn\u011Bn\u00ED (z pohledu s\u00E9rologick\u00E9ho, ohledn\u011B aktivity z\u00E1n\u011Btu i pokro\u010Dilosti p\u0159estavby jatern\u00EDho parenchymu) pro ur\u010Den\u00ED vhodn\u00E9ho l\u00E9\u010Debn\u00E9ho sch\u00E9matu. V textu je pod\u00E1n p\u0159ehled histopatologick\u00FDch klasifikac\u00ED chronick\u00FDch hepatitid z klinick\u00E9ho pohledu, diskutov\u00E1no je postaven\u00ED a p\u0159\u00EDnos jatern\u00ED biopsie v dob\u011B rozvoje neinvazivn\u00EDch metod pro stanoven\u00ED stupn\u011B p\u0159estavby jatern\u00EDho parenchymu (p\u0159edev\u0161\u00EDm elastografie). V z\u00E1v\u011Bru jsou shrnuty principy modern\u00ED l\u00E9\u010Dby nej\u010Dast\u011Bj\u0161\u00EDch chronick\u00FDch virov\u00FDch hepatitid (B, C) se zd\u016Frazn\u011Bn\u00EDm situac\u00ED, kde m\u016F\u017Ee histopatologick\u00E9 vy\u0161et\u0159en\u00ED jatern\u00ED tk\u00E1n\u011B sehr\u00E1t roli v indikaci nebo ovlivn\u011Bn\u00ED l\u00E9\u010Debn\u00E9ho sch\u00E9matu."@cs . . "1210-7875" . "Viral hepatitis at the beginning of the 21th century \u2013 value of liver biopsy in the context of development of new non-invasive diagnostic methods and in relation to the modern therapy of chronic viral hepatitis"@en . "The rapid progress in the development of virostatic agents over the past 15 years has changed chronic viral hepatitis from causally incurable diseases to diseases that may be treated or even cured. But, the treatment is a long-term process and it remains very expensive. Therefore, it is important to establish the correct diagnosis with the exact stratification of the disease (in terms of serological findings, regarding the activity of the inflammation and alterations of liver parenchyma) to determine the appropriate treatment schedule. The text includes an overview of histopathological classifications of chronic hepatitis from the clinical perspective; we discuss the contribution of liver biopsy in the era of the development of non-invasive diagnostic methods for determining the degree of alteration of liver parenchyma (elastography in particular). Furthermore, the principles of modern therapy of the most common chronic viral hepatitis (i.e. B and C) are summarized with emphasis on situations where the histopathological examination of liver tissue plays a role in the indication or affects the treatment schedule."@en . "Za posledn\u00EDch 15 let zm\u011Bnil rychl\u00FD pokrok ve v\u00FDvoji virostatik chronick\u00E9 virov\u00E9 hepatitidy z kauz\u00E1ln\u011B nel\u00E9\u010Diteln\u00FDch onemocn\u011Bn\u00ED na nemoci, kter\u00E9 lze u cel\u00E9 \u0159ady pacient\u016F l\u00E9\u010Dit a vyl\u00E9\u010Dit. L\u00E9\u010Dba je v\u0161ak dlouhodob\u00E1 a velmi n\u00E1kladn\u00E1. I proto je d\u016Fle\u017Eit\u00E1 spr\u00E1vn\u00E1 diagn\u00F3za s p\u0159esnou stratifikac\u00ED onemocn\u011Bn\u00ED (z pohledu s\u00E9rologick\u00E9ho, ohledn\u011B aktivity z\u00E1n\u011Btu i pokro\u010Dilosti p\u0159estavby jatern\u00EDho parenchymu) pro ur\u010Den\u00ED vhodn\u00E9ho l\u00E9\u010Debn\u00E9ho sch\u00E9matu. V textu je pod\u00E1n p\u0159ehled histopatologick\u00FDch klasifikac\u00ED chronick\u00FDch hepatitid z klinick\u00E9ho pohledu, diskutov\u00E1no je postaven\u00ED a p\u0159\u00EDnos jatern\u00ED biopsie v dob\u011B rozvoje neinvazivn\u00EDch metod pro stanoven\u00ED stupn\u011B p\u0159estavby jatern\u00EDho parenchymu (p\u0159edev\u0161\u00EDm elastografie). V z\u00E1v\u011Bru jsou shrnuty principy modern\u00ED l\u00E9\u010Dby nej\u010Dast\u011Bj\u0161\u00EDch chronick\u00FDch virov\u00FDch hepatitid (B, C) se zd\u016Frazn\u011Bn\u00EDm situac\u00ED, kde m\u016F\u017Ee histopatologick\u00E9 vy\u0161et\u0159en\u00ED jatern\u00ED tk\u00E1n\u011B sehr\u00E1t roli v indikaci nebo ovlivn\u011Bn\u00ED l\u00E9\u010Debn\u00E9ho sch\u00E9matu." . "2" . "Virov\u00E9 hepatitidy na za\u010D\u00E1tku 21. stolet\u00ED - v\u00FDznam jatern\u00ED biopsie v kontextu rozvoje neinvazivn\u00EDch diagnostick\u00FDch metod a ve vztahu k modern\u00ED l\u00E9\u010Db\u011B chronick\u00FDch virov\u00FDch hepatitid" . . . "Viral hepatitis at the beginning of the 21th century \u2013 value of liver biopsy in the context of development of new non-invasive diagnostic methods and in relation to the modern therapy of chronic viral hepatitis"@en . . . "47-56" . "RIV/00064203:_____/11:7302" . "1"^^ . "Vitou\u0161, A." . "Virov\u00E9 hepatitidy na za\u010D\u00E1tku 21. stolet\u00ED - v\u00FDznam jatern\u00ED biopsie v kontextu rozvoje neinvazivn\u00EDch diagnostick\u00FDch metod a ve vztahu k modern\u00ED l\u00E9\u010Db\u011B chronick\u00FDch virov\u00FDch hepatitid"@cs . "I" . "2"^^ . "\u010Cesko-slovensk\u00E1 patologie a soudn\u00ED l\u00E9ka\u0159stv\u00ED" . . "Virov\u00E9 hepatitidy na za\u010D\u00E1tku 21. stolet\u00ED - v\u00FDznam jatern\u00ED biopsie v kontextu rozvoje neinvazivn\u00EDch diagnostick\u00FDch metod a ve vztahu k modern\u00ED l\u00E9\u010Db\u011B chronick\u00FDch virov\u00FDch hepatitid" . "[DF71029F911C]" . "CZ - \u010Cesk\u00E1 republika" . "Virov\u00E9 hepatitidy na za\u010D\u00E1tku 21. stolet\u00ED - v\u00FDznam jatern\u00ED biopsie v kontextu rozvoje neinvazivn\u00EDch diagnostick\u00FDch metod a ve vztahu k modern\u00ED l\u00E9\u010Db\u011B chronick\u00FDch virov\u00FDch hepatitid"@cs . . . . . . "RIV/00064203:_____/11:7302!RIV12-MZ0-00064203" . "238480" . "6"^^ . . "http://www.medvik.cz/link/bmc11010686" . . "Viral hepatitis; biopsy"@en .