"We previously demonstrated that outcome of pediatric 11q23/MLL-rearranged AML depends on the translocation partner (TP). In this multicenter international study on 733 children with 11q23/MLL-rearranged AML, we further analyzed which additional cytogenetic aberrations (ACA) had prognostic significance. ACAs occurred in 344 (47%) of 733 and were associated with unfavorable outcome (5-year overall survival [OS] 47% vs 62%, P < .001). Trisomy 8, the most frequent specificACA(n = 130/344, 38%), independently predicted favorable outcome within the ACAs group (OS 61% vs 39%, P = .003; Cox model for OS hazard ratio (HR) 0.54, P = .03), on the basis of reduced relapse rate (26% vs 49%, P < .001). Trisomy 19 (n = 37/344, 11%) independently predicted poor prognosis in ACAs cases, which was partly caused by refractory disease (remission rate 74% vs 89%, P = .04; OS 24% vs 50%, P < .001; HR 1.77, P = .01). Structural ACAs had independent adverse prognostic value for event-free survival (HR 1.36, P = .01). Complex karyotype, defined as >= 3 abnormalities, was present in 26% (n = 192/733) and showed worse outcome than those without complex karyotype (OS 45% vs 59%, P = .003) in univariate analysis only. In conclusion, like TP, specific ACAs have independent prognostic significance in pediatric 11q23/MLL-rearranged AML, and the mechanism underlying these prognostic differences should be studied. (Blood. 2011;117(26):7102-7111)" . . "Rubnitz, J. E" . . . "Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11q23/MLL-rearranged AML patients: results of an international study"@en . "Perot, C." . . "34"^^ . "Harrison, CJ" . "0006-4971" . "Chang, M." . "Pieters, R." . "Blood" . "Beverloo, H. B." . "Kaspers, GJL" . "Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11q23/MLL-rearranged AML patients: results of an international study"@en . . "Alonzo, TA" . "Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11q23/MLL-rearranged AML patients: results of an international study" . "Tomizawa, D." . "Forestier, E." . "RIV/00064203:_____/11:7050" . "Dworzak, MN" . . "Gibson, B." . "Star\u00FD, Jan" . "acute myeloid-leukemia; acute myeloblastic-leukemia; oncology-group; myelodysplastic syndrome; complex karyotype; up-regulation; childrens-cancer; poor-prognosis; gene-mutations; trials"@en . "Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11q23/MLL-rearranged AML patients: results of an international study" . "Raimondi, SC" . "Lo Nigro, L." . . "26" . . "Hasle, H." . "Strehl, S." . . "Morimoto, A." . "Reinhardt, D." . . "Zimmermann, M." . "000292244000019" . . . . "Taga, T." . "Zwaan, CM" . "[0EE4076B9DBA]" . "Smith, FO" . "Creutzig, U." . "I, V" . "Auvrignon, A." . . "Coenen, E. A." . "1"^^ . "http://www.ncbi.nlm.nih.gov/pubmed/21551233" . "Stasevich, I." . . . . "RIV/00064203:_____/11:7050!RIV12-MZ0-00064203" . . . "Harbott, J." . "10"^^ . "Webb, D." . . . "Zemanov\u00E1, Z." . . "Litvinko, N." . "Leszl, A." . "We previously demonstrated that outcome of pediatric 11q23/MLL-rearranged AML depends on the translocation partner (TP). In this multicenter international study on 733 children with 11q23/MLL-rearranged AML, we further analyzed which additional cytogenetic aberrations (ACA) had prognostic significance. ACAs occurred in 344 (47%) of 733 and were associated with unfavorable outcome (5-year overall survival [OS] 47% vs 62%, P < .001). Trisomy 8, the most frequent specificACA(n = 130/344, 38%), independently predicted favorable outcome within the ACAs group (OS 61% vs 39%, P = .003; Cox model for OS hazard ratio (HR) 0.54, P = .03), on the basis of reduced relapse rate (26% vs 49%, P < .001). Trisomy 19 (n = 37/344, 11%) independently predicted poor prognosis in ACAs cases, which was partly caused by refractory disease (remission rate 74% vs 89%, P = .04; OS 24% vs 50%, P < .001; HR 1.77, P = .01). Structural ACAs had independent adverse prognostic value for event-free survival (HR 1.36, P = .01). Complex karyotype, defined as >= 3 abnormalities, was present in 26% (n = 192/733) and showed worse outcome than those without complex karyotype (OS 45% vs 59%, P = .003) in univariate analysis only. In conclusion, like TP, specific ACAs have independent prognostic significance in pediatric 11q23/MLL-rearranged AML, and the mechanism underlying these prognostic differences should be studied. (Blood. 2011;117(26):7102-7111)"@en . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "224378" . "van den Heuvel-Eibrink, MM" . "117" . "Heerema, NA" .