"7" . "RIV/00064203:_____/10:6697!RIV11-MZ0-00064203" . "6"^^ . "Od imunopatologie diabetu 1. typu k imunointervenci"@cs . . "CZ - \u010Cesk\u00E1 republika" . . . "Diabetes 1.typu je v\u00FDznamn\u00FD socioekonomick\u00FD probl\u00E9m. Podkladem jeho vzniku je autoimunitn\u00ED destruktivn\u00ED insulitida. Kl\u00ED\u010Dov\u00E1 role je p\u0159ipisov\u00E1na autoreaktivn\u00ED T lymfocyt\u016Fm, kter\u00E9 jsou polarizov\u00E1ny ve sm\u011Bru Th1. Nicm\u00E9n\u011B se ukazuje, \u017Ee odchylky u pacient\u016F s diabetem 1.typu m\u016F\u017Eeme naj\u00EDt i nap\u0159\u00EDklad na \u00FArovni regula\u010Dn\u00EDch T lymfocyt\u016F \u010Di na \u00FArovni zpracov\u00E1n\u00ED a prezentace antigenu. Po \u00FAvodn\u00EDm p\u0159ibl\u00ED\u017Een\u00ED sou\u010Dasn\u00E9ho pohledu na imunopatologii t\u00E9to choroby se \u010Dl\u00E1nek zab\u00FDv\u00E1 nejv\u00FDznamn\u011Bj\u0161\u00EDmi imunointerven\u010Dn\u00EDmi studiemi, kter\u00E9 byly dosud ve sm\u011Bru k diabetu 1. typu realizov\u00E1ny."@cs . "Od imunopatologie diabetu 1. typu k imunointervenci" . . . . "Diabetes 1.typu je v\u00FDznamn\u00FD socioekonomick\u00FD probl\u00E9m. Podkladem jeho vzniku je autoimunitn\u00ED destruktivn\u00ED insulitida. Kl\u00ED\u010Dov\u00E1 role je p\u0159ipisov\u00E1na autoreaktivn\u00ED T lymfocyt\u016Fm, kter\u00E9 jsou polarizov\u00E1ny ve sm\u011Bru Th1. Nicm\u00E9n\u011B se ukazuje, \u017Ee odchylky u pacient\u016F s diabetem 1.typu m\u016F\u017Eeme naj\u00EDt i nap\u0159\u00EDklad na \u00FArovni regula\u010Dn\u00EDch T lymfocyt\u016F \u010Di na \u00FArovni zpracov\u00E1n\u00ED a prezentace antigenu. Po \u00FAvodn\u00EDm p\u0159ibl\u00ED\u017Een\u00ED sou\u010Dasn\u00E9ho pohledu na imunopatologii t\u00E9to choroby se \u010Dl\u00E1nek zab\u00FDv\u00E1 nejv\u00FDznamn\u011Bj\u0161\u00EDmi imunointerven\u010Dn\u00EDmi studiemi, kter\u00E9 byly dosud ve sm\u011Bru k diabetu 1. typu realizov\u00E1ny." . . . "Od imunopatologie diabetu 1. typu k imunointervenci"@cs . . "From type 1 diabetes immunopathology to immunointervention"@en . . . "276292" . "From type 1 diabetes immunopathology to immunointervention"@en . "diabetes; immunointervention; prevention"@en . . . "Od imunopatologie diabetu 1. typu k imunointervenci" . . "1"^^ . "\u0160techov\u00E1, Kate\u0159ina" . "RIV/00064203:_____/10:6697" . "Type 1 diabetes is a serious disease from a social as well as an economic point of view. The underlying mechanism of the disease is an autoimmune destructive insulitis with the crucial role of autoreactive T cells which are Th1 polarised. Also other abnormalities such as differences in T regulatory cells or a difference in antigen processing and presentation may contribute to the disease onset as well. In this publication current knowledge on complex type 1 diabetes immunopathology is introduced and this section is followed by an analysis of the most important immunointervention studies which have been conducted in relationship to this disease."@en . "[641DDDD586FA]" . . "P(2B06019), P(2B08066), Z(MZ0FNM2005)" . "Postgradu\u00E1ln\u00ED medic\u00EDna" . . "12" . "1"^^ . "1212-4184" . . .