. "Polymorfismus genu pro serotoninov\u00FD transport\u00E9r 5-HTT v etiologii psychiatrick\u00FDch onemocn\u011Bn\u00ED"@cs . "Macek jr., Milan" . . . "Ku\u017Eelov\u00E1, Hana" . "2" . "Serotonin transporter plays an important role in serotogenic transmisssion and the serotonin transporter gene is under investigation in connection with many psychiatric disorders. There are two main genetic variations in the promoter region of the gene - long (L) allele and a short (S). The S allele is associated with decreased transcriptional efficiency of the promoter leads to reduced serotonin re-uptake in comparison to the long allele which is associated with greater gene expression. The length of polymorphisms are considered to be important mediators of emotional instability and predisposition to mental illness, high trait anxiety, fear-related behavior, negative emotions. The serotonin transporter gene has received much attention in association with psychiatric disorders and its explication can improve understanding to its principles."@en . "106" . . "1212-0383" . "Serotonin transporter gene polymorphism in etiology of psychiatric disorders"@en . "Polymorfismus genu pro serotoninov\u00FD transport\u00E9r 5-HTT v etiologii psychiatrick\u00FDch onemocn\u011Bn\u00ED" . . . "Serotoninov\u00FD transport\u00E9r 5-HTT hraje d\u016Fle\u017Eitou roli v serotonergn\u00ED neurotransmisi a gen k\u00F3duj\u00EDc\u00ED tento protein pat\u0159\u00ED mezi nejsledovan\u011Bj\u0161\u00ED geny v souvislosti s psychiatrick\u00FDmi onemocn\u011Bn\u00EDmi. Vyskytuj\u00ED se dv\u011B z\u00E1kladn\u00ED varianty - kr\u00E1tk\u00E1 (S) a dlouh\u00E1 (L), o jejich\u017E d\u00E9lce rozhoduj\u00ED repetitivn\u00ED sekvence v promotorov\u00E9 oblasti genu. Kr\u00E1tk\u00E1 varianta S je spojov\u00E1na s ni\u017E\u0161\u00ED transkrip\u010Dn\u00ED \u010Dinnost\u00ED genov\u00E9ho promotoru a m\u00E1 souvislost s vy\u0161\u0161\u00ED senzitivitou k podn\u011Bt\u016Fm vyvol\u00E1vaj\u00EDc\u00EDm \u00FAzkost a strach. Alela L je naopak spojov\u00E1na s ni\u017E\u0161\u00EDm v\u00FDskytem \u00FAzkostn\u00FDch a depresivn\u00EDch stav\u016F, ale v souvislosti s n\u011Bkter\u00FDmi poruchami pravd\u011Bpodobn\u011B p\u0159isp\u00EDv\u00E1 k projev\u016Fm vy\u0161\u0161\u00ED agresivity, psychomotorick\u00E9ho neklidu a emo\u010Dn\u00ED nestability. Tyto souvislosti jsou v oblasti modern\u00ED genetiky a biologick\u00E9 psychiatrie p\u0159edm\u011Btem intenzivn\u00EDho v\u00FDzkumu a jejich objasn\u011Bn\u00ED m\u016F\u017Ee v\u00FDrazn\u00FDm zp\u016Fsobem napomoci porozum\u011Bn\u00ED podstat\u011B n\u011Bkter\u00FDch du\u0161evn\u00EDch onemocn\u011Bn\u00ED, kter\u00E9 tak povede k efektivn\u011Bj\u0161\u00ED l\u00E9\u010Db\u011B." . . "279791" . . . "[06D21B9FAADF]" . . "Serotoninov\u00FD transport\u00E9r 5-HTT hraje d\u016Fle\u017Eitou roli v serotonergn\u00ED neurotransmisi a gen k\u00F3duj\u00EDc\u00ED tento protein pat\u0159\u00ED mezi nejsledovan\u011Bj\u0161\u00ED geny v souvislosti s psychiatrick\u00FDmi onemocn\u011Bn\u00EDmi. Vyskytuj\u00ED se dv\u011B z\u00E1kladn\u00ED varianty - kr\u00E1tk\u00E1 (S) a dlouh\u00E1 (L), o jejich\u017E d\u00E9lce rozhoduj\u00ED repetitivn\u00ED sekvence v promotorov\u00E9 oblasti genu. Kr\u00E1tk\u00E1 varianta S je spojov\u00E1na s ni\u017E\u0161\u00ED transkrip\u010Dn\u00ED \u010Dinnost\u00ED genov\u00E9ho promotoru a m\u00E1 souvislost s vy\u0161\u0161\u00ED senzitivitou k podn\u011Bt\u016Fm vyvol\u00E1vaj\u00EDc\u00EDm \u00FAzkost a strach. Alela L je naopak spojov\u00E1na s ni\u017E\u0161\u00EDm v\u00FDskytem \u00FAzkostn\u00FDch a depresivn\u00EDch stav\u016F, ale v souvislosti s n\u011Bkter\u00FDmi poruchami pravd\u011Bpodobn\u011B p\u0159isp\u00EDv\u00E1 k projev\u016Fm vy\u0161\u0161\u00ED agresivity, psychomotorick\u00E9ho neklidu a emo\u010Dn\u00ED nestability. Tyto souvislosti jsou v oblasti modern\u00ED genetiky a biologick\u00E9 psychiatrie p\u0159edm\u011Btem intenzivn\u00EDho v\u00FDzkumu a jejich objasn\u011Bn\u00ED m\u016F\u017Ee v\u00FDrazn\u00FDm zp\u016Fsobem napomoci porozum\u011Bn\u00ED podstat\u011B n\u011Bkter\u00FDch du\u0161evn\u00EDch onemocn\u011Bn\u00ED, kter\u00E9 tak povede k efektivn\u011Bj\u0161\u00ED l\u00E9\u010Db\u011B."@cs . . "2"^^ . . "3"^^ . "\u010Cesk\u00E1 a slovensk\u00E1 psychiatrie" . "Serotonin transporter gene polymorphism in etiology of psychiatric disorders"@en . . "7"^^ . . . "Ptacek, R." . "RIV/00064203:_____/10:6093" . "CZ - \u010Cesk\u00E1 republika" . "5-HTT; Etiology of psychiatric disorders; Genetics; Serotonin transporter"@en . "I" . "RIV/00064203:_____/10:6093!RIV11-MZ0-00064203" . "Polymorfismus genu pro serotoninov\u00FD transport\u00E9r 5-HTT v etiologii psychiatrick\u00FDch onemocn\u011Bn\u00ED"@cs . "Polymorfismus genu pro serotoninov\u00FD transport\u00E9r 5-HTT v etiologii psychiatrick\u00FDch onemocn\u011Bn\u00ED" . .