"Alogenn\u00ED transplantace kmenov\u00FDch bun\u011Bk krvetvorby (HSCT) je p\u0159\u00EDle\u017Eitost\u00ED ke sledov\u00E1n\u00ED kinetiky rekonstituce dendritick\u00FDch bun\u011Bk (DC) a jej\u00ED dynamiky za r\u016Fzn\u00FDch patologi\u00ED. V t\u00E9to pr\u00E1ci jsme analyzovali rekonstituci DC po myeloablativn\u00ED HSCT. Monitorace prob\u00EDhala od nej\u010Dasn\u011Bj\u0161\u00ED f\u00E1ze hematopoetick\u00E9 rekonstituce do D+365 po transplantaci. Myeloidn\u00ED i plazmacytoidn\u00ED DC se objevily v nej\u010Dasn\u011Bj\u0161\u00EDch st\u00E1di\u00EDch po p\u0159ihojen\u00ED \u0161t\u011Bpu, jejich relativn\u00ED pod\u00EDl v r\u00E1mci b\u00EDl\u00FDch krvinek byl nejvy\u0161\u0161\u00ED mezi D+19 a D+25 po HSCT a pot\u00E9 jejich proporce klesala. Pacienti s akutn\u00ED reakc\u00ED \u0161t\u011Bpu proti hostiteli (aGVHD) m\u011Bli v\u00FDrazn\u011B ni\u017E\u0161\u00ED po\u010Det cirkuluj\u00EDc\u00EDch dendritick\u00FDch bun\u011Bk. Pokles po\u010Dtu DC p\u0159edch\u00E1zel n\u00E1stupu klinick\u00FDch symptom\u016F nejm\u00E9n\u011B o 24 hodin a byl nez\u00E1visl\u00FD na pod\u00E1v\u00E1n\u00ED kortikosteroid\u016F. Kvantifikace plazmacytoidn\u00EDch a myeloidn\u00EDch DC tedy m\u016F\u017Ee slou\u017Eit jako pomocn\u00E9 vy\u0161et\u0159en\u00ED upozor\u0148uj\u00EDc\u00ED na rozvoj akutn\u00ED GVHD." . "Rekonstituce dendritick\u00FDch bun\u011Bk po myeloablativn\u00ED alogenn\u00ED transplantaci kmenov\u00FDch bun\u011Bk krvetvorby a jej\u00ED poruchy u akutn\u00ED GVHD"@cs . "Rekonstituce dendritick\u00FDch bun\u011Bk po myeloablativn\u00ED alogenn\u00ED transplantaci kmenov\u00FDch bun\u011Bk krvetvorby a jej\u00ED poruchy u akutn\u00ED GVHD" . . . "1212-3536" . . "8"^^ . "Acute GVHD; BMT; Corticosteroids; Dendritic cell; HSCT"@en . "Kalina, Tom\u00E1\u0161" . . "Reconstitution of dendritic cells after myeloablative allogeneic haematopoetic stem cell transplantation: Implications for the development of acute graft-versus host disease"@en . . . . . . "Reconstitution of dendritic cells after myeloablative allogeneic haematopoetic stem cell transplantation: Implications for the development of acute graft-versus host disease"@en . . "\u0160p\u00ED\u0161ek, Radek" . "P(GA310/08/0838), Z(MSM0021620812), Z(MZ0FNM2005)" . . . "Budinsk\u00FD, V\u00EDt" . . . "RIV/00064203:_____/10:6076" . . "Alergie" . "RIV/00064203:_____/10:6076!RIV11-GA0-00064203" . "8"^^ . . . "4" . "Allogeneic hematopoetic stem cell transplantation (HSCT) represents a unique opportunity to monitor the kinetics of reconstitution of dendritic cells (DCs) and their dynamics in distinct pathologies. We analyzed DCs reconstitution after myeloablative HSCT. We separately analyzed patients with acute GVHD. DCs were monitored from the earliest phase of hematopoetic reconstitution until day +365. Both myeloid DCs and plasmacytoid DCs appeared at earliest stages after engraftment and relative numbers within white blood cells compartment peaked between days 19-25 after HSCT. Their proportion then gradually declined and absolute numbers of both DC subsets remained lower than in controls during the whole follow-up. Patients with acute GVHD had significantly lower numbers of circulating DCs. Decrease in DC counts preceded onset of clinical symptoms by at least 24h and was independent of corticosteroids administration."@en . "Form\u00E1nkov\u00E1, Renata" . "Zlabova, A." . "Bart\u016F\u0148kov\u00E1, Ji\u0159ina" . "CZ - \u010Cesk\u00E1 republika" . "9"^^ . "Rekonstituce dendritick\u00FDch bun\u011Bk po myeloablativn\u00ED alogenn\u00ED transplantaci kmenov\u00FDch bun\u011Bk krvetvorby a jej\u00ED poruchy u akutn\u00ED GVHD" . . "284576" . . "12" . "[6081C742DDDA]" . . . . . "Horv\u00E1th, Rudolf" . "Rekonstituce dendritick\u00FDch bun\u011Bk po myeloablativn\u00ED alogenn\u00ED transplantaci kmenov\u00FDch bun\u011Bk krvetvorby a jej\u00ED poruchy u akutn\u00ED GVHD"@cs . "Kayserov\u00E1, Jana" . "Alogenn\u00ED transplantace kmenov\u00FDch bun\u011Bk krvetvorby (HSCT) je p\u0159\u00EDle\u017Eitost\u00ED ke sledov\u00E1n\u00ED kinetiky rekonstituce dendritick\u00FDch bun\u011Bk (DC) a jej\u00ED dynamiky za r\u016Fzn\u00FDch patologi\u00ED. V t\u00E9to pr\u00E1ci jsme analyzovali rekonstituci DC po myeloablativn\u00ED HSCT. Monitorace prob\u00EDhala od nej\u010Dasn\u011Bj\u0161\u00ED f\u00E1ze hematopoetick\u00E9 rekonstituce do D+365 po transplantaci. Myeloidn\u00ED i plazmacytoidn\u00ED DC se objevily v nej\u010Dasn\u011Bj\u0161\u00EDch st\u00E1di\u00EDch po p\u0159ihojen\u00ED \u0161t\u011Bpu, jejich relativn\u00ED pod\u00EDl v r\u00E1mci b\u00EDl\u00FDch krvinek byl nejvy\u0161\u0161\u00ED mezi D+19 a D+25 po HSCT a pot\u00E9 jejich proporce klesala. Pacienti s akutn\u00ED reakc\u00ED \u0161t\u011Bpu proti hostiteli (aGVHD) m\u011Bli v\u00FDrazn\u011B ni\u017E\u0161\u00ED po\u010Det cirkuluj\u00EDc\u00EDch dendritick\u00FDch bun\u011Bk. Pokles po\u010Dtu DC p\u0159edch\u00E1zel n\u00E1stupu klinick\u00FDch symptom\u016F nejm\u00E9n\u011B o 24 hodin a byl nez\u00E1visl\u00FD na pod\u00E1v\u00E1n\u00ED kortikosteroid\u016F. Kvantifikace plazmacytoidn\u00EDch a myeloidn\u00EDch DC tedy m\u016F\u017Ee slou\u017Eit jako pomocn\u00E9 vy\u0161et\u0159en\u00ED upozor\u0148uj\u00EDc\u00ED na rozvoj akutn\u00ED GVHD."@cs . . . . . "Sedl\u00E1\u010Dek, Petr" .