. "243-251" . . . "ellipticine; anticancer drug; peroxidase; cytochrome P450; DNA adduct; xenobiotic-metabolizing enzymes; covalent binding; breast-cancer; catalyzed activation; elliptinium acetate; mediated oxidation; cytochromes p450; antitumor agent; cell-line; sudan-i"@en . . . "Ellipticine is a potent antineoplastic agent, whose mode of action is considered to be based mainly on DNA intercalation, inhibition of topoisomerase II and cytochrome P450-mediated formation of covalent DNA adducts."@en . "Sav\u010D\u00ED peroxid\u00E1zy aktivuj\u00ED protin\u00E1dorov\u00FD l\u00E9k elipticin, co\u017E umo\u017E\u0148uje tvorbu deoxyguanozinov\u00FDch addukt\u016F v DNA, kter\u00E9 jsou shodn\u00E9 s addukty vyvolan\u00FDmi 12-hydroxyelipticinem a 13-hydroxyelipticinem in vivo"@cs . "Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those found in vivo and generated from 12-hydroxyellipticine and 13-hydroxyellipticine"@en . . . . "0020-7136" . . "1"^^ . "International Journal of Cancer" . . "CH - \u0160v\u00FDcarsk\u00E1 konfederace" . . "RIV/00064203:_____/07:1577!RIV08-MSM-00064203" . "Sav\u010D\u00ED peroxid\u00E1zy aktivuj\u00ED protin\u00E1dorov\u00FD l\u00E9k elipticin, co\u017E umo\u017E\u0148uje tvorbu deoxyguanozinov\u00FDch addukt\u016F v DNA, kter\u00E9 jsou shodn\u00E9 s addukty vyvolan\u00FDmi 12-hydroxyelipticinem a 13-hydroxyelipticinem in vivo"@cs . "P(GA203/06/0329), Z(MSM0021620808), Z(MSM0021620813)" . . "120" . . "9"^^ . "6"^^ . . . . . . . . . . . . "Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those found in vivo and generated from 12-hydroxyellipticine and 13-hydroxyellipticine" . "431825" . "Eckschlager, Tom\u00E1\u0161" . "Sav\u010D\u00ED peroxid\u00E1zy aktivuj\u00ED protin\u00E1dorov\u00FD l\u00E9k elipticin, co\u017E umo\u017E\u0148uje tvorbu deoxyguanozinov\u00FDch addukt\u016F v DNA, kter\u00E9 jsou shodn\u00E9 s addukty vyvolan\u00FDmi 12-hydroxyelipticinem a 13-hydroxyelipticinem in vivo"@cs . . . "[A8A0E5E91879]" . "Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those found in vivo and generated from 12-hydroxyellipticine and 13-hydroxyellipticine" . "Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those found in vivo and generated from 12-hydroxyellipticine and 13-hydroxyellipticine"@en . . "2" . "RIV/00064203:_____/07:1577" . . "Ellipticine is a potent antineoplastic agent, whose mode of action is considered to be based mainly on DNA intercalation, inhibition of topoisomerase II and cytochrome P450-mediated formation of covalent DNA adducts." . . .