. . . . . "http://www.tigis.cz/images/stories/Bolest/2012/02/03_niedermayerova_bolest_2-12.pdf" . "Markov\u00E1, Jolana" . "RIV/00064190:_____/12:#0000328" . . "Neurotransmitter systems, especialy serotoninergic and noradrenergic systems, play a significant role in the pathophysiology of the the pain and the depression. Mechanism of the effect of antidepressants is the inhibition of the presynaptic reuptake of the mediators that results to higher biologic availability on the postsynaptic receptors. Low concentration of neurotransmitters in the synaptic gap for a long time leads slowly and gradually to downregulation of the presynaptic autoreceptors and some postsynaptic receptors. There are several pharmacological mechanisms of action of antidepressants that include noradrenalinergic and serotoninergic modulations, direct and indirect effects on opioids receptors, inhibition cholinergic, histamine and NMDA (N-methyl-D-aspartate) receptors and influence of activity ion chanals. Antidepressants are effective in the therapy of neuropathic pain caused by polyneuropathies of the various aetiology and radicular vertebral syndroms, by management of some secondary headaches (trigeminal neuralgia) and primary headaches (migraine, tension type of headache-TTH). Antidepressants have depeveloped from a less specific classic tricyclic and heterocyclic antidepressants (I. and II.generation) to drugs that inhibit very specific single mediator (III. and IV generation)."@en . . "Bolest" . . "CZ - \u010Cesk\u00E1 republika" . . "1212-0634" . . "antidepressants; migraine; tension type of headache; amitriptyline; venlafaxine"@en . . "122930" . "V" . "Antidepresiva v l\u00E9\u010Db\u011B bolest\u00ED hlavy" . . "15" . "RIV/00064190:_____/12:#0000328!RIV13-MZ0-00064190" . "[D60365686A44]" . . "V patofyziologii bolesti a deprese se uplat\u0148uj\u00ED n\u011Bkter\u00E9 stejn\u00E9 neuromedi\u00E1torov\u00E9 syst\u00E9my, a to p\u0159edev\u0161\u00EDm noradrenergn\u00ED a serotoninergn\u00ED. Mechanizmem \u00FA\u010Dinku antidepresiv je blok\u00E1da zp\u011Btn\u00E9ho vychyt\u00E1v\u00E1n\u00ED medi\u00E1tor\u016F do presynaptick\u00E9ho zakon\u010Den\u00ED, \u010D\u00EDm\u017E se zv\u00FD\u0161\u00ED jejich biologick\u00E1 dostupnost na postsynaptick\u00FDch receptorech. Dlouhodob\u011B sn\u00ED\u017Een\u00E1 koncentrace neurotransmiter\u016F v synaptick\u00E9 \u0161t\u011Brbin\u011B pomalu a postupn\u011B sni\u017Euje po\u010Det (downregulaci) presynaptick\u00FDch autoreceptor\u016F a n\u011Bkter\u00FDch postsynaptick\u00FDch receptor\u016F. Antidepresiva vykazuj\u00ED v\u011Bt\u0161\u00ED po\u010Det farmakologick\u00FDch mechanizm\u016F, v\u010Detn\u011B noradrenalinov\u00E9 a serotoninov\u00E9 modulace, p\u0159\u00EDm\u00FDch i nep\u0159\u00EDm\u00FDch efekt\u016F na opioidn\u00ED receptory, inhibice cholinergn\u00EDch, histaminov\u00FDch i NMDA (N-methyl-D-aspart\u00E1t) receptor\u016F i ovlivn\u011Bn\u00ED aktivity iontov\u00FDch kan\u00E1lk\u016F. Antidepresiva jsou vyu\u017E\u00EDv\u00E1na v terapii neuropatick\u00E9 bolesti p\u0159i polyneuropati\u00EDch nejr\u016Fzn\u011Bj\u0161\u00ED etiologie, radikul\u00E1rn\u00EDch vertebrogenn\u00EDch syndromech, p\u0159i bolestech hlavy sekund\u00E1rn\u00EDch (neuralgii trojklan\u00E9ho nervu) a prim\u00E1rn\u00EDch (migr\u00E9n\u011B a bolesti hlavy tenzn\u00EDho typu). Antidepresiva ve sv\u00E9m v\u00FDvoji pro\u0161la od m\u00E9n\u011B specificky p\u016Fsob\u00EDc\u00EDch klasick\u00FDch tricyklick\u00FDch a heterocyklick\u00FDch antidepresiv (I. a II. generace) a\u017E k l\u00E1tk\u00E1m blokuj\u00EDc\u00EDm velmi specificky jednotliv\u00E9 medi\u00E1tory (III. a IV. generace)." . . "Antidepresiva v l\u00E9\u010Db\u011B bolest\u00ED hlavy"@cs . "Antidepressants in the treatment of headaches"@en . "2" . "2"^^ . . "Niedermayerov\u00E1, I." . "Antidepresiva v l\u00E9\u010Db\u011B bolest\u00ED hlavy" . "5"^^ . "V patofyziologii bolesti a deprese se uplat\u0148uj\u00ED n\u011Bkter\u00E9 stejn\u00E9 neuromedi\u00E1torov\u00E9 syst\u00E9my, a to p\u0159edev\u0161\u00EDm noradrenergn\u00ED a serotoninergn\u00ED. Mechanizmem \u00FA\u010Dinku antidepresiv je blok\u00E1da zp\u011Btn\u00E9ho vychyt\u00E1v\u00E1n\u00ED medi\u00E1tor\u016F do presynaptick\u00E9ho zakon\u010Den\u00ED, \u010D\u00EDm\u017E se zv\u00FD\u0161\u00ED jejich biologick\u00E1 dostupnost na postsynaptick\u00FDch receptorech. Dlouhodob\u011B sn\u00ED\u017Een\u00E1 koncentrace neurotransmiter\u016F v synaptick\u00E9 \u0161t\u011Brbin\u011B pomalu a postupn\u011B sni\u017Euje po\u010Det (downregulaci) presynaptick\u00FDch autoreceptor\u016F a n\u011Bkter\u00FDch postsynaptick\u00FDch receptor\u016F. Antidepresiva vykazuj\u00ED v\u011Bt\u0161\u00ED po\u010Det farmakologick\u00FDch mechanizm\u016F, v\u010Detn\u011B noradrenalinov\u00E9 a serotoninov\u00E9 modulace, p\u0159\u00EDm\u00FDch i nep\u0159\u00EDm\u00FDch efekt\u016F na opioidn\u00ED receptory, inhibice cholinergn\u00EDch, histaminov\u00FDch i NMDA (N-methyl-D-aspart\u00E1t) receptor\u016F i ovlivn\u011Bn\u00ED aktivity iontov\u00FDch kan\u00E1lk\u016F. Antidepresiva jsou vyu\u017E\u00EDv\u00E1na v terapii neuropatick\u00E9 bolesti p\u0159i polyneuropati\u00EDch nejr\u016Fzn\u011Bj\u0161\u00ED etiologie, radikul\u00E1rn\u00EDch vertebrogenn\u00EDch syndromech, p\u0159i bolestech hlavy sekund\u00E1rn\u00EDch (neuralgii trojklan\u00E9ho nervu) a prim\u00E1rn\u00EDch (migr\u00E9n\u011B a bolesti hlavy tenzn\u00EDho typu). Antidepresiva ve sv\u00E9m v\u00FDvoji pro\u0161la od m\u00E9n\u011B specificky p\u016Fsob\u00EDc\u00EDch klasick\u00FDch tricyklick\u00FDch a heterocyklick\u00FDch antidepresiv (I. a II. generace) a\u017E k l\u00E1tk\u00E1m blokuj\u00EDc\u00EDm velmi specificky jednotliv\u00E9 medi\u00E1tory (III. a IV. generace)."@cs . . . "Antidepressants in the treatment of headaches"@en . "1"^^ . "Antidepresiva v l\u00E9\u010Db\u011B bolest\u00ED hlavy"@cs .