. . "Aplikace Dysportu(R) - mo\u017Enost doprovodn\u00E9ho vedlej\u0161\u00EDho efektu na postaven\u00ED v\u00ED\u010Dek: klinicko-histologick\u00E1 studie"@cs . "RIV/00064173:_____/12:43907113!RIV13-MZ0-00064173" . . . "RIV/00064173:_____/12:43907113" . "C\u00EDl: Sezn\u00E1mit s mo\u017Enost\u00ED negativn\u00EDho dopadu opakovan\u00E9ho pod\u00E1n\u00ED deriv\u00E1tu botulotoxinu A na postaven\u00ED v\u00ED\u010Dek se zm\u011Bnami jejich tk\u00E1\u0148ov\u00E9 struktury. Sou\u010Dasn\u011B auto\u0159i pod\u00E1vaj\u00ED liter\u00E1rn\u00ED rozbor pozitivn\u00EDho a negativn\u00EDho vlivu tohoto neurotoxinu z medic\u00EDnsk\u00E9ho hlediska. Materi\u00E1l a metodika: Na O\u010Dn\u00ED klinice FN Kr\u00E1lovsk\u00E9 Vinohrady v Praze byli v letech 2006 a\u017E 2008 chirurgicky o\u0161et\u0159eni t\u0159i pacienti po opakovan\u00FDch aplikac\u00EDch deriv\u00E1t\u016F botulotoxinu A. Jednou se jednalo o oboustrannou pt\u00F3zu horn\u00EDch v\u00ED\u010Dek a dvakr\u00E1t byla indikac\u00ED entropia s trichi\u00E1zou doln\u00EDch v\u00ED\u010Dek. Po anamnesticky ud\u00E1van\u00E9 10let\u00E9 l\u00E9\u010Db\u011B pro pracovn\u00ED diagn\u00F3zu blefarospazmu byla aplikac\u00ED v\u00FD\u0161e uveden\u00E9ho l\u00E9ku u 65let\u00E9ho mu\u017Ee vyvolan\u00E1 oboustrann\u00E1 symetrick\u00E1 pt\u00F3za. Vzhledem k n\u00E1sledn\u00E9mu posti\u017Een\u00ED m. frontalis i \u010D\u00E1ste\u010Dn\u00E9mu oslaben\u00ED funkce lev\u00E1tor\u016F v\u00ED\u010Dek byl stav postaven\u00ED horn\u00EDch v\u00ED\u010Dek \u0159e\u0161en plastikou aponeur\u00F3zy s dobr\u00FDm funk\u010Dn\u00EDm v\u00FDsledkem. U dvou pacientek ve v\u011Bku 72 a 90 let bylo indikac\u00ED \u00FAsp\u011B\u0161n\u00E9 chirurgick\u00E9 intervence trvale p\u0159etrv\u00E1vaj\u00EDc\u00ED entropium doln\u00EDch v\u00ED\u010Dek p\u016Fvodn\u011B neefektivn\u011B \u0159e\u0161en\u00E9 opakovan\u00FDmi intraderm\u00E1ln\u00EDmi injekcemi p\u0159\u00EDpravky na b\u00E1zi botulotoxinu A. V\u00FDsledky: Histologick\u00E1 vy\u0161et\u0159en\u00ED odebran\u00FDch vzork\u016F k\u016F\u017Ee a podko\u017E\u00ED p\u0159i plastik\u00E1ch entropi\u00ED uk\u00E1zala nep\u0159\u00EDzniv\u00E9 a ireverzibiln\u00ED zm\u011Bny, mezi kter\u00E9 pat\u0159ilo zejm\u00E9na projizven\u00ED v\u00ED\u010Dka a atrofie snopc\u016F p\u0159\u00ED\u010Dn\u011B pruhovan\u00E9ho svalu. Z\u00E1v\u011Br: Indikace aplikace deriv\u00E1t\u016F botulotoxinu v obli\u010Deji je nutno v\u017Edy dob\u0159e zv\u00E1\u017Eit a volit spr\u00E1vnou indikaci. Z o\u010Dn\u00EDho hlediska je pln\u011B vhodnou diagn\u00F3zou pouze blefarospazmus a relativn\u00ED indikac\u00ED je do\u010Dasn\u011B vyvolan\u00E1 pt\u00F3za horn\u00EDho v\u00ED\u010Dka uzav\u00EDraj\u00EDc\u00ED o\u010Dn\u00ED \u0161t\u011Brbinu z d\u016Fvodu prevence rohovkov\u00FDch zm\u011Bn u lagoftalmu r\u016Fzn\u00E9 etiologie jako eventualita tarzorafie. V\u017Edy je nutno posoudit \u010Detnost aplikac\u00ED, nebo\u0165 opakovan\u011B pou\u017E\u00EDvan\u00FD deriv\u00E1t tohoto neurotoxinu zanech\u00E1v\u00E1 nevratn\u00E9 zm\u011Bny v ko\u017En\u00ED a podko\u017En\u00ED tk\u00E1ni."@cs . "The aplication of Dysport(R) - the possibilities of the side effect on the eyelides position (a clinical - histological study)"@en . "http://www.prolekare.cz/ceska-slovenska-oftalmologie-clanek/aplikace-dysportu-sup-sup-moznost-doprovodneho-vedlejsiho-efektu-na-postaveni-vicek-klinicko-histologicka-studie-39911" . "1211-9059" . "Aplikace Dysportu(R) - mo\u017Enost doprovodn\u00E9ho vedlej\u0161\u00EDho efektu na postaven\u00ED v\u00ED\u010Dek: klinicko-histologick\u00E1 studie"@cs . . . "I" . . "5" . . . "Aplikace Dysportu(R) - mo\u017Enost doprovodn\u00E9ho vedlej\u0161\u00EDho efektu na postaven\u00ED v\u00ED\u010Dek: klinicko-histologick\u00E1 studie" . . "\u0160ach, Josef" . . . . "CZ - \u010Cesk\u00E1 republika" . "The aplication of Dysport(R) - the possibilities of the side effect on the eyelides position (a clinical - histological study)"@en . "treatment side effect; ptosis; histology; entropium; botulotoxine A"@en . . "123096" . "Kr\u00E1sn\u00FD, Jan" . . "[A337FD763313]" . "Aplikace Dysportu(R) - mo\u017Enost doprovodn\u00E9ho vedlej\u0161\u00EDho efektu na postaven\u00ED v\u00ED\u010Dek: klinicko-histologick\u00E1 studie" . "Aim: To inform about the possibility of negative influence of repeated application of the botulotoxine A derivate on the eye lid position with the changes of their tissue structure. At the same moment, the authors report on literature analysis of positive and negative influence of this neuro toxine from the medical point of view. Materials and methods: At the Department of Ophthalmology in the Faculty Hospital Kr\u00E1lovsk\u00E9 Vinohrady, Prague, Czech Republic, E.U., there were surgically treated three patients after repeated applications of botulotoxine A derivates. The first case was bilateral ptosis of upper eyelids; the other two were indicated because of entropium with trichiasis of lower eyelids. In the medical history, there was recorded ten years lasting above-mentioned drug treatment for blepharospasm diagnosis in a 65 years old man introducing bilateral symmetrical ptosis. Because of the following frontal muscle involvement, and partial decreasing levator palpebrae muscles function, the positioning of the upper eyelids was treated by the aponeurosis plasty with good functional result. In two female patients, aged 72 and 90 years, the indication for successful surgical treatment was chronic entropium of lower eyelids; initially ineffectively treated by means of repeated intradermal injections of botulotoxin A derivates. Conclusion: The indication of botulotoxine A derivates application should be carefully weighted and the proper indication should be chosen. From the ophthalmologic point of view, blefarospasmus only is the appropriate diagnosis, and the relative indication is the temporary induced ptosis of the upper eyelid closing the interpalpebral fissure to prevent corneal changes in lagophthalmos of various etiologies as an alternative to the tarsoraphy. Always we have to consider the frequency of applications, because repeatedly used derivate of this neurotoxine causes irreversible changes in cutaneous and subcutaneous tissue."@en . "5"^^ . . "2"^^ . . "2"^^ . "C\u00EDl: Sezn\u00E1mit s mo\u017Enost\u00ED negativn\u00EDho dopadu opakovan\u00E9ho pod\u00E1n\u00ED deriv\u00E1tu botulotoxinu A na postaven\u00ED v\u00ED\u010Dek se zm\u011Bnami jejich tk\u00E1\u0148ov\u00E9 struktury. Sou\u010Dasn\u011B auto\u0159i pod\u00E1vaj\u00ED liter\u00E1rn\u00ED rozbor pozitivn\u00EDho a negativn\u00EDho vlivu tohoto neurotoxinu z medic\u00EDnsk\u00E9ho hlediska. Materi\u00E1l a metodika: Na O\u010Dn\u00ED klinice FN Kr\u00E1lovsk\u00E9 Vinohrady v Praze byli v letech 2006 a\u017E 2008 chirurgicky o\u0161et\u0159eni t\u0159i pacienti po opakovan\u00FDch aplikac\u00EDch deriv\u00E1t\u016F botulotoxinu A. Jednou se jednalo o oboustrannou pt\u00F3zu horn\u00EDch v\u00ED\u010Dek a dvakr\u00E1t byla indikac\u00ED entropia s trichi\u00E1zou doln\u00EDch v\u00ED\u010Dek. Po anamnesticky ud\u00E1van\u00E9 10let\u00E9 l\u00E9\u010Db\u011B pro pracovn\u00ED diagn\u00F3zu blefarospazmu byla aplikac\u00ED v\u00FD\u0161e uveden\u00E9ho l\u00E9ku u 65let\u00E9ho mu\u017Ee vyvolan\u00E1 oboustrann\u00E1 symetrick\u00E1 pt\u00F3za. Vzhledem k n\u00E1sledn\u00E9mu posti\u017Een\u00ED m. frontalis i \u010D\u00E1ste\u010Dn\u00E9mu oslaben\u00ED funkce lev\u00E1tor\u016F v\u00ED\u010Dek byl stav postaven\u00ED horn\u00EDch v\u00ED\u010Dek \u0159e\u0161en plastikou aponeur\u00F3zy s dobr\u00FDm funk\u010Dn\u00EDm v\u00FDsledkem. U dvou pacientek ve v\u011Bku 72 a 90 let bylo indikac\u00ED \u00FAsp\u011B\u0161n\u00E9 chirurgick\u00E9 intervence trvale p\u0159etrv\u00E1vaj\u00EDc\u00ED entropium doln\u00EDch v\u00ED\u010Dek p\u016Fvodn\u011B neefektivn\u011B \u0159e\u0161en\u00E9 opakovan\u00FDmi intraderm\u00E1ln\u00EDmi injekcemi p\u0159\u00EDpravky na b\u00E1zi botulotoxinu A. V\u00FDsledky: Histologick\u00E1 vy\u0161et\u0159en\u00ED odebran\u00FDch vzork\u016F k\u016F\u017Ee a podko\u017E\u00ED p\u0159i plastik\u00E1ch entropi\u00ED uk\u00E1zala nep\u0159\u00EDzniv\u00E9 a ireverzibiln\u00ED zm\u011Bny, mezi kter\u00E9 pat\u0159ilo zejm\u00E9na projizven\u00ED v\u00ED\u010Dka a atrofie snopc\u016F p\u0159\u00ED\u010Dn\u011B pruhovan\u00E9ho svalu. Z\u00E1v\u011Br: Indikace aplikace deriv\u00E1t\u016F botulotoxinu v obli\u010Deji je nutno v\u017Edy dob\u0159e zv\u00E1\u017Eit a volit spr\u00E1vnou indikaci. Z o\u010Dn\u00EDho hlediska je pln\u011B vhodnou diagn\u00F3zou pouze blefarospazmus a relativn\u00ED indikac\u00ED je do\u010Dasn\u011B vyvolan\u00E1 pt\u00F3za horn\u00EDho v\u00ED\u010Dka uzav\u00EDraj\u00EDc\u00ED o\u010Dn\u00ED \u0161t\u011Brbinu z d\u016Fvodu prevence rohovkov\u00FDch zm\u011Bn u lagoftalmu r\u016Fzn\u00E9 etiologie jako eventualita tarzorafie. V\u017Edy je nutno posoudit \u010Detnost aplikac\u00ED, nebo\u0165 opakovan\u011B pou\u017E\u00EDvan\u00FD deriv\u00E1t tohoto neurotoxinu zanech\u00E1v\u00E1 nevratn\u00E9 zm\u011Bny v ko\u017En\u00ED a podko\u017En\u00ED tk\u00E1ni." . . "\u010Cesk\u00E1 a slovensk\u00E1 oftalmologie" . "68" .