"L\u00EDbalov\u00E1, Pavla" . "RIV/00064173:_____/10:00002431!RIV13-MZ0-00064173" . . "EJSO - European Journal of Surgical Oncology" . . . "000276678000002" . "I, P(NS9975)" . "The role of steroid receptor coactivator-3 (SRC-3) in human malignant disease" . . "0748-7983" . "2"^^ . "tumor marker; steroid receptor coactivator 3"@en . "36" . . "6"^^ . . . "[D2689C38E1FC]" . "6"^^ . . "The p160 steroid receptor coactivator (SRC) family is critical to the transcriptional activation function of nuclear hormone receptors. A key member of this family is SRC-3, initially found to be amplified and expressed in breast cancer it has subsequent been shown to be expressed in malignant disease arising from a wide range of other organs. An understanding of the potential role of SRC-3 in the pathogenesis and its possible prognostic role in a broad range of tumours will improve our general understanding of carcinogenesis as well as potentially leading to a new prognostic marker as well as new therapeutic targets. SRC-3 appears to be implicated in the possible risk of developing prostate and ovarian cancer. Its presence appears to be a marker of aggressive disease. Further research is required to determine its predictive and prognostic utility given the relative paucity of studies for each specific malignant disease." . . . "The role of steroid receptor coactivator-3 (SRC-3) in human malignant disease" . . . "10.1016/j.ejso.2009.08.002" . "3" . "RIV/00064173:_____/10:00002431" . "The role of steroid receptor coactivator-3 (SRC-3) in human malignant disease"@en . "The p160 steroid receptor coactivator (SRC) family is critical to the transcriptional activation function of nuclear hormone receptors. A key member of this family is SRC-3, initially found to be amplified and expressed in breast cancer it has subsequent been shown to be expressed in malignant disease arising from a wide range of other organs. An understanding of the potential role of SRC-3 in the pathogenesis and its possible prognostic role in a broad range of tumours will improve our general understanding of carcinogenesis as well as potentially leading to a new prognostic marker as well as new therapeutic targets. SRC-3 appears to be implicated in the possible risk of developing prostate and ovarian cancer. Its presence appears to be a marker of aggressive disease. Further research is required to determine its predictive and prognostic utility given the relative paucity of studies for each specific malignant disease."@en . . "Goji\u0161, Ond\u0159ej" . . "285752" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . . "The role of steroid receptor coactivator-3 (SRC-3) in human malignant disease"@en .