. "Roztrou\u0161en\u00E1 skler\u00F3za p\u0159edstavuje v na\u0161ich zem\u011Bpisn\u00FDch \u0161\u00ED\u0159k\u00E1ch nej\u010Dast\u011Bj\u0161\u00ED autoimunitn\u00ED onemocn\u011Bn\u00ED centr\u00E1ln\u00EDho nervov\u00E9ho syst\u00E9mu. Onemocn\u011Bn\u00ED m\u016F\u017Ee v\u00E9st k r\u016Fzn\u00E9mu stupni neurologick\u00E9ho posti\u017Een\u00ED v z\u00E1vislosti na agresivit\u011B pr\u016Fb\u011Bhu vlastn\u00ED RS, v\u010Dasn\u00E9m zah\u00E1jen\u00ED l\u00E9\u010Dby a jej\u00EDm individu\u00E1ln\u00EDm efektu. Zhruba u 3% pacient\u016F lze pr\u016Fb\u011Bh RS ozna\u010Dit za malign\u00ED, kdy jsou od po\u010D\u00E1tku choroby p\u0159\u00EDtomny ataky z\u00E1va\u017En\u00E9 neurologick\u00E9 symptomatiky s rychl\u00FDm n\u00E1r\u016Fstem trval\u00E9ho neurologick\u00E9ho posti\u017Een\u00ED i p\u0159es adekv\u00E1tn\u00ED l\u00E9\u010Dbu." . "Autologn\u00ED transplantace kmenov\u00FDch krvetvorn\u00FDch bun\u011Bk a jej\u00ED sou\u010Dasn\u00E1 role v l\u00E9\u010Db\u011B roztrou\u0161en\u00E9 skler\u00F3zy"@cs . "Autologn\u00ED transplantace kmenov\u00FDch krvetvorn\u00FDch bun\u011Bk a jej\u00ED sou\u010Dasn\u00E1 role v l\u00E9\u010Db\u011B roztrou\u0161en\u00E9 skler\u00F3zy" . "Autologn\u00ED transplantace kmenov\u00FDch krvetvorn\u00FDch bun\u011Bk a jej\u00ED sou\u010Dasn\u00E1 role v l\u00E9\u010Db\u011B roztrou\u0161en\u00E9 skler\u00F3zy"@cs . "Havrdov\u00E1, E." . "\u010Cesk\u00E1 a slovensk\u00E1 neurologie a neurochirurgie" . . "Trn\u011Bn\u00FD, M." . . "1210-7859" . "Koz\u00E1k, Tom\u00E1\u0161" . "I, P(1A8713), P(NR9375), P(NS9986), Z(MSM0021620849)" . "RIV/00064173:_____/09:#0000052" . . "CZ - \u010Cesk\u00E1 republika" . . "Roztrou\u0161en\u00E1 skler\u00F3za p\u0159edstavuje v na\u0161ich zem\u011Bpisn\u00FDch \u0161\u00ED\u0159k\u00E1ch nej\u010Dast\u011Bj\u0161\u00ED autoimunitn\u00ED onemocn\u011Bn\u00ED centr\u00E1ln\u00EDho nervov\u00E9ho syst\u00E9mu. Onemocn\u011Bn\u00ED m\u016F\u017Ee v\u00E9st k r\u016Fzn\u00E9mu stupni neurologick\u00E9ho posti\u017Een\u00ED v z\u00E1vislosti na agresivit\u011B pr\u016Fb\u011Bhu vlastn\u00ED RS, v\u010Dasn\u00E9m zah\u00E1jen\u00ED l\u00E9\u010Dby a jej\u00EDm individu\u00E1ln\u00EDm efektu. Zhruba u 3% pacient\u016F lze pr\u016Fb\u011Bh RS ozna\u010Dit za malign\u00ED, kdy jsou od po\u010D\u00E1tku choroby p\u0159\u00EDtomny ataky z\u00E1va\u017En\u00E9 neurologick\u00E9 symptomatiky s rychl\u00FDm n\u00E1r\u016Fstem trval\u00E9ho neurologick\u00E9ho posti\u017Een\u00ED i p\u0159es adekv\u00E1tn\u00ED l\u00E9\u010Dbu."@cs . . . "3" . . "Krasulov\u00E1, E." . . . "multiple sclerosis, malignant, immunoablation, stem cell transplantation, ASCT"@en . . "72" . . "1"^^ . "[FD9550F42043]" . . "4"^^ . "Multiple sclerosis (MS) is the most frequent autoimmune disorder of the central nervous system in our geographical region. The disease can lead to variable degree of neurological disability according to aggressiveness of MS course itself, early treatment initiation and its invidividual efficacy. In about 3% of the patients MS course can be classified as malignant with severe attacks from the beginning of the disease and rapid accumulation of neurological disability despite adequate treatment. Kl\u00ED\u010Dov\u00E1 slova v angl. (RIV): multiple sclerosis; malignant; immunoablation; stem cell transplantation; ASCT"@en . "304440" . "8"^^ . . "RIV/00064173:_____/09:#0000052!RIV11-MZ0-00064173" . . . . "Autologous Hematopoietic Stem Cells Transplantation and its Current Role in Multiple Sclerosis Treatment"@en . . "Autologous Hematopoietic Stem Cells Transplantation and its Current Role in Multiple Sclerosis Treatment"@en . . . . . "Autologn\u00ED transplantace kmenov\u00FDch krvetvorn\u00FDch bun\u011Bk a jej\u00ED sou\u010Dasn\u00E1 role v l\u00E9\u010Db\u011B roztrou\u0161en\u00E9 skler\u00F3zy" .