. "p53 is implemented in many processes controlling cell fate. Recently it has been reported that besides post-translational modifications and regulation of protein-protein interactions, the activity of p53 is also substantially controlled at transcriptional level. In 109 out of 127 (86%) patients with chronic lymphocytic leukemia (CLL) we have identified a novel p53 splicing variant, lacking the whole coding sequence of exon 6. This splicing p53 isoform (%22delta ex6%22) is devoid of transactivational activity and is differentially expressed in CLL patients as compared to healthy controls. The overexpression of %22delta ex6%22 p53 variant in CLL patients supports the recent evidence on dysregulation of p53 splicing pattern in malignancies"@en . "10.1016/j.leukres.2007.06.022" . . . "yeast; protein; modifier; radiation; expression; phosphatase; mdm2; mutation; isoforms; functional assay"@en . . "Leukemia Research" . "P(NR9186), V" . . "Identification of a novel, trans activation-defective splicing variant of p53 gene in patients with chronic lymphocytic leukemia" . . . "000254597400005" . . . "2"^^ . "0145-2126" . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . "RIV/00064173:_____/08:00001288!RIV13-MZ0-00064173" . . . "371198" . "Identification of a novel, trans activation-defective splicing variant of p53 gene in patients with chronic lymphocytic leukemia" . "\u0160pa\u010Dek, Martin" . . . "3" . . "6"^^ . . . . . . "[30DF25609CA6]" . "RIV/00064173:_____/08:00001288" . "6"^^ . "p53 is implemented in many processes controlling cell fate. Recently it has been reported that besides post-translational modifications and regulation of protein-protein interactions, the activity of p53 is also substantially controlled at transcriptional level. In 109 out of 127 (86%) patients with chronic lymphocytic leukemia (CLL) we have identified a novel p53 splicing variant, lacking the whole coding sequence of exon 6. This splicing p53 isoform (%22delta ex6%22) is devoid of transactivational activity and is differentially expressed in CLL patients as compared to healthy controls. The overexpression of %22delta ex6%22 p53 variant in CLL patients supports the recent evidence on dysregulation of p53 splicing pattern in malignancies" . . "32" . . . "Identification of a novel, trans activation-defective splicing variant of p53 gene in patients with chronic lymphocytic leukemia"@en . "Koz\u00E1k, Tom\u00E1\u0161" . "Identification of a novel, trans activation-defective splicing variant of p53 gene in patients with chronic lymphocytic leukemia"@en .