. . . "Bimonthly Evolution of Cortical Atrophy in Early Relapsing-Remitting Multiple Sclerosis over 2 Years : A Longitudinal Study" . "Dole\u017Eal, Ond\u0159ej" . "8"^^ . "6"^^ . "Bimonthly Evolution of Cortical Atrophy in Early Relapsing-Remitting Multiple Sclerosis over 2 Years : A Longitudinal Study"@en . . . "Bimonthly Evolution of Cortical Atrophy in Early Relapsing-Remitting Multiple Sclerosis over 2 Years : A Longitudinal Study" . . "We investigated the evolution of cortical atrophy in patients with early relapsing-remitting (RR) multiple sclerosis (MS) and its association with lesion volume (LV) accumulation and disability progression. 136 of 181 RRMS patients who participated in the Avonex-Steroids-Azathioprine study were assessed bimonthly for clinical and MRI outcomes over 2 years. MS patients with disease duration (DD) at baseline of LESS-THAN OR EQUAL TO24 months were classified in the early group (DD of 1.2 years, n = 37), while patients with DD > 24 months were classified in the late group (DD of 7.1 years, n = 99). Mixed effect model analysis was used to investigate the associations. Significant changes in whole brain volume (WBV) (P < 0.001), cortical volume (CV) (P < 0.001), and in T2-LV (P < 0.001) were detected. No significant MRI percent change differences were detected between early and late DD groups over 2 years, except for increased T2-LV accumulation between baseline and year 2 in the early DD group (P < 0.01). No significant associations were found between changes in T2-LV and CV over the followup. Change in CV was related to the disability progression over the 2 years, after adjusting for DD (P = 0.01). Significant cortical atrophy, independent of T2-LV accumulation, occurs in early RRMS over 2 years, and it is associated with the disability progression." . . "Havrdov\u00E1, Eva" . "RIV/00064165:_____/13:10193093!RIV14-MZ0-00064165" . . "2090-2654" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Ramasamy, Deepa P." . "Hor\u00E1kov\u00E1, Dana" . . . "Kr\u00E1sensk\u00FD, Jan" . "Multiple Sclerosis International" . . . . "Seidl, Zden\u011Bk" . "Tekwe, Carmen" . "RIV/00064165:_____/13:10193093" . "[BF6905253A72]" . . "10.1155/2013/231345" . "63360" . . . "Bimonthly Evolution of Cortical Atrophy in Early Relapsing-Remitting Multiple Sclerosis over 2 Years : A Longitudinal Study"@en . "I, P(NT13237), Z(MSM0021620849)" . . "We investigated the evolution of cortical atrophy in patients with early relapsing-remitting (RR) multiple sclerosis (MS) and its association with lesion volume (LV) accumulation and disability progression. 136 of 181 RRMS patients who participated in the Avonex-Steroids-Azathioprine study were assessed bimonthly for clinical and MRI outcomes over 2 years. MS patients with disease duration (DD) at baseline of LESS-THAN OR EQUAL TO24 months were classified in the early group (DD of 1.2 years, n = 37), while patients with DD > 24 months were classified in the late group (DD of 7.1 years, n = 99). Mixed effect model analysis was used to investigate the associations. Significant changes in whole brain volume (WBV) (P < 0.001), cortical volume (CV) (P < 0.001), and in T2-LV (P < 0.001) were detected. No significant MRI percent change differences were detected between early and late DD groups over 2 years, except for increased T2-LV accumulation between baseline and year 2 in the early DD group (P < 0.01). No significant associations were found between changes in T2-LV and CV over the followup. Change in CV was related to the disability progression over the 2 years, after adjusting for DD (P = 0.01). Significant cortical atrophy, independent of T2-LV accumulation, occurs in early RRMS over 2 years, and it is associated with the disability progression."@en . "Van\u011B\u010Dkov\u00E1, Manuela" . . . "Dwyer, Michael G." . . "http://www.hindawi.com/journals/msi/2013/231345/" . . . "Bergsland, Niels" . "Neuveden" . "11"^^ . . . "Zivadinov, Robert" . "Jan" . . "Longitudinal Study; Relapsing-Remitting Multiple Sclerosis; Cortical Atrophy; Bimonthly Evolution"@en .