"[DD015265D6D0]" . "0022-3050" . . "Zivadinov, Robert" . "85057" . . "Kr\u00E1sensk\u00FD, Jan" . . . "10.1136/jnnp-2012-304740" . . "Magnetic Resonance Imaging; Demyelinating Diseases; Czech Republic; Cohort Studies; Cholesterol, LDL; Cholesterol, HDL; Cholesterol; Calcifediol; Brain; Body Mass Index; Adult"@en . "RIV/00064165:_____/13:10193014" . "Lipid profiles are associated with lesion formation over 24 months in interferon-beta treated patients following the first demyelinating event"@en . "I, P(NT13237), Z(MSM0021620849)" . . . "Seidl, Zden\u011Bk" . "Weinstock-Guttman, Bianca" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "84" . . "000329373100230" . "Objectives: To investigate the associations of serum lipid profile with disease progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. Methods: High density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were obtained in pretreatment serum from 135 high risk patients with CIS (GREATER-THAN OR EQUAL TO2 brain MRI lesions and GREATER-THAN OR EQUAL TO2 oligoclonal bands) enrolled in the Observational Study of Early Interferon \u03B2-1a Treatment in High Risk Subjects after CIS study (SET study), which prospectively evaluated the effect of intramuscular interferon \u03B2-1a treatment following the first demyelinating event. Thyroid stimulating hormone, free thyroxine, 25-hydroxy vitamin D3, active smoking status and body mass index were also obtained. Clinical and MRI assessments were obtained within 4 months of the initial demyelinating event and at 6, 12 and 24 months. Results: The time to first relapse and number of relapses were not associated with any of the lipid profile variables. Higher LDL-C (p=0.006) and TC (p=0.001) levels were associated with increased cumulative number of new T2 lesions over 2 years. Higher free thyroxine levels were associated with lower cumulative number of contrast-enhancing lesions (p=0.008). Higher TC was associated as a trend with lower baseline whole brain volume (p=0.020). Higher high density lipoprotein was associated with higher deseasonalised 1,25-dihydroxy vitamin D3 (p=0.003) levels and a trend was found for deseasonalised 25-hydroxy vitamin D3 (p=0.014). Conclusions: In early multiple sclerosis, lipid profile variables particularly LDL-C and TC levels are associated with inflammatory MRI activity measures."@en . "Havrdov\u00E1, Eva" . . "Lipid profiles are associated with lesion formation over 24 months in interferon-beta treated patients following the first demyelinating event" . . "Lipid profiles are associated with lesion formation over 24 months in interferon-beta treated patients following the first demyelinating event"@en . "Shyh, Grace" . "Journal of Neurology, Neurosurgery and Psychiatry" . "RIV/00064165:_____/13:10193014!RIV14-MZ0-00064165" . "Willis, Laura" . . . . . "Hussein, Sarra" . "Objectives: To investigate the associations of serum lipid profile with disease progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. Methods: High density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were obtained in pretreatment serum from 135 high risk patients with CIS (GREATER-THAN OR EQUAL TO2 brain MRI lesions and GREATER-THAN OR EQUAL TO2 oligoclonal bands) enrolled in the Observational Study of Early Interferon \u03B2-1a Treatment in High Risk Subjects after CIS study (SET study), which prospectively evaluated the effect of intramuscular interferon \u03B2-1a treatment following the first demyelinating event. Thyroid stimulating hormone, free thyroxine, 25-hydroxy vitamin D3, active smoking status and body mass index were also obtained. Clinical and MRI assessments were obtained within 4 months of the initial demyelinating event and at 6, 12 and 24 months. Results: The time to first relapse and number of relapses were not associated with any of the lipid profile variables. Higher LDL-C (p=0.006) and TC (p=0.001) levels were associated with increased cumulative number of new T2 lesions over 2 years. Higher free thyroxine levels were associated with lower cumulative number of contrast-enhancing lesions (p=0.008). Higher TC was associated as a trend with lower baseline whole brain volume (p=0.020). Higher high density lipoprotein was associated with higher deseasonalised 1,25-dihydroxy vitamin D3 (p=0.003) levels and a trend was found for deseasonalised 25-hydroxy vitamin D3 (p=0.014). Conclusions: In early multiple sclerosis, lipid profile variables particularly LDL-C and TC levels are associated with inflammatory MRI activity measures." . "6"^^ . "http://dx.doi.org/10.1136/jnnp-2012-304740" . "O'Connor, Kerri" . . . "Qu, Jun" . "Tamano-Blanco, Miriam" . . "Ramanathan, Murali" . "Badgett, Darlene" . "T\u00FDblov\u00E1, Michaela" . "Lipid profiles are associated with lesion formation over 24 months in interferon-beta treated patients following the first demyelinating event" . "Bergsland, Niels" . . . . . . "11" . "Hor\u00E1kov\u00E1, Dana" . . . . . "18"^^ . "6"^^ . . "Lakota, Elizabeth" . "Van\u011B\u010Dkov\u00E1, Manuela" . . . . . .