"1"^^ . . . "Family history of idiopathic REM behavior disorder a multicenter case-control study"@en . "80" . "3"^^ . "0028-3878" . . "polysomnography; Parkinson disease; parent; parasomnia; familial disease; Alzheimer disease; Idiopathic REM sleep behavior disorder"@en . . "Postuma, RB" . "Montplaisir, Jacques" . "I" . . . "000330733500014" . "Jennum, Poul" . . "Family history of idiopathic REM behavior disorder a multicenter case-control study"@en . . "http://dx.doi.org/10.1212/WNL.0b013e318296e967" . . . "RIV/00064165:_____/13:10192195" . "Miyamoto, Tomoyuki" . "10.1212/WNL.0b013e318296e967" . "Frauscher, Birgit" . . "H\u00F6gl, Birgit" . "\u0160onka, Karel" . "Family history of idiopathic REM behavior disorder a multicenter case-control study" . "Wolfson, Christina" . "Desautels, Alex" . "Oertel, Wolfgang" . "Miyamoto, Masayuki" . "Neurology" . "Arnulf, Isabelle" . "22"^^ . "Fantini, Maria Livia" . . "Dauvilliers, Yves" . "Leu-Semenescu, Smeranda" . "24" . "Zucconi, Marco" . "Terzaghi, Michele" . "Ferini-Strambi, Luigi" . "Unger, Marcus" . "74627" . . . "RIV/00064165:_____/13:10192195!RIV14-MZ0-00064165" . "Objective: To compare the frequency of proxy-reported REM sleep behavior disorder (RBD) among relatives of patients with polysomnogram-diagnosed idiopathic RBD (iRBD) in comparison to controls using a large multicenter clinic-based cohort. Methods: A total of 316 patients with polysomnography- confirmed iRBD were recruited from 12 RBD study group centers, along with 316 controls matched on sex and age group. All subjects completed a self-administered questionnaire that collected proxy-reported information on family history of tremor, gait trouble, balance trouble, Parkinson disease, memory loss, and Alzheimer disease. The questionnaire also included a single question that asked about possible symptoms of RBD among first-degree relatives (siblings, parents, and children). Results: A positive family history of dream enactment was reported in 13.8% of iRBD cases compared to 4.8% of controls (odds ratio [OR] = 3.9, 95% confidence interval [CI] 2.0-7.7). ORs were increased for both siblings (OR = 6.1, 95% CI 2.1-18.1) and parents (OR = 3.2, 95% CI 1.4-7.8). We found no significant difference in sex, current age (65.3 +- 10.2 vs 66.9 +- 10.2 years), or age at self-reported RBD onset (55.2 +- 11.7 vs 56.6 +- 15.1 years) in possible familial vs sporadic iRBD. No differences were found in family history of tremor, walking and balance troubles, Parkinson disease, memory loss, or Alzheimer disease. Conclusion: We found increased odds of proxy-reported family history of presumed RBD among individuals with confirmed iRBD. This suggests the possibility of a genetic contribution to RBD"@en . "Family history of idiopathic REM behavior disorder a multicenter case-control study" . "[68CA22F78D46]" . . . . . "Objective: To compare the frequency of proxy-reported REM sleep behavior disorder (RBD) among relatives of patients with polysomnogram-diagnosed idiopathic RBD (iRBD) in comparison to controls using a large multicenter clinic-based cohort. Methods: A total of 316 patients with polysomnography- confirmed iRBD were recruited from 12 RBD study group centers, along with 316 controls matched on sex and age group. All subjects completed a self-administered questionnaire that collected proxy-reported information on family history of tremor, gait trouble, balance trouble, Parkinson disease, memory loss, and Alzheimer disease. The questionnaire also included a single question that asked about possible symptoms of RBD among first-degree relatives (siblings, parents, and children). Results: A positive family history of dream enactment was reported in 13.8% of iRBD cases compared to 4.8% of controls (odds ratio [OR] = 3.9, 95% confidence interval [CI] 2.0-7.7). ORs were increased for both siblings (OR = 6.1, 95% CI 2.1-18.1) and parents (OR = 3.2, 95% CI 1.4-7.8). We found no significant difference in sex, current age (65.3 +- 10.2 vs 66.9 +- 10.2 years), or age at self-reported RBD onset (55.2 +- 11.7 vs 56.6 +- 15.1 years) in possible familial vs sporadic iRBD. No differences were found in family history of tremor, walking and balance troubles, Parkinson disease, memory loss, or Alzheimer disease. Conclusion: We found increased odds of proxy-reported family history of presumed RBD among individuals with confirmed iRBD. This suggests the possibility of a genetic contribution to RBD" . . "Puligheddu, Monica" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Manni, Raffaele" . "Pelletier, Am\u00E9lie" .