"Zah\u00E1jen\u00ED l\u00E9\u010Dby interferonem beta v nevhodn\u00E9 f\u00E1zi nemoci" . . . "Zah\u00E1jen\u00ED l\u00E9\u010Dby interferonem beta v nevhodn\u00E9 f\u00E1zi nemoci" . . . . "CZ - \u010Cesk\u00E1 republika" . . "A case report of a patient with multiple sclerosis diagnosed in 1996 illustrates the impact of delayed biological treatment intervention on patient prognosis. Interferon beta therapy initiated after more than 10 years of immunosuppressive treatment including cyclophosphamide and mitoxantrone was entirely ineffective, the inflammatory activity continued, and the patient was finally switched to escalation regimen with natalizumab. Although the disease course could potentially be assessed as secondary progressive with the presence of inflammatory activity, her neurological status improved by 2.0 points on the Kurtzke Expanded Disability Status Scale during the first year of natalizumab treatment"@en . "Zah\u00E1jen\u00ED l\u00E9\u010Dby interferonem beta v nevhodn\u00E9 f\u00E1zi nemoci"@cs . "117758" . "\u010Cesk\u00E1 a slovensk\u00E1 neurologie a neurochirurgie" . "P\u0159\u00EDpad pacientky s roztrou\u0161enou skler\u00F3zou diagnostikovanou v roce 1996 upozor\u0148uje na vliv pozdn\u00EDho zah\u00E1jen\u00ED l\u00E9\u010Dby biologickou l\u00E9\u010Dbou na progn\u00F3zu pacientky. L\u00E9\u010Dba interferonem beta zah\u00E1jen\u00E1 po v\u00EDce ne\u017E 10 letech imuniosupresivn\u00ED l\u00E9\u010Dby v\u010Detn\u011B pulzn\u00EDho pod\u00E1v\u00E1n\u00ED cyklofosfamidu a mitoxantronu byla zcela neefektivn\u00ED. Z\u00E1n\u011Btliv\u00E1 aktivita pokra\u010Dovala a pacentka byla posl\u00E9ze p\u0159evedena na eskala\u010Dn\u00ED l\u00E9\u010Dbu natalizumabem P\u0159esto\u017Ee pr\u016Fb\u011Bh choroby by na prvn\u00ED pohled bylo mo\u017En\u00E9 v t\u00E9 dob\u011B hodnotit i jako sekund\u00E1rn\u011B progresivn\u00ED, av\u0161ak s je\u0161t\u011B zachovanou z\u00E1n\u011Btlivou aktivitou nemoci, do\u0161lo ji\u017E b\u011Bhem prvn\u00EDho roku l\u00E9\u010Dby natalizumabem ke zlep\u0161en\u00ED o dva stupn\u011B Kurtzkeho \u0161k\u00E1ly disability." . . . "Zah\u00E1jen\u00ED l\u00E9\u010Dby interferonem beta v nevhodn\u00E9 f\u00E1zi nemoci"@cs . "Interferon Beta Therapy Initiation at an Inappropriate Phase of the Disease"@en . . "RIV/00064165:_____/13:10188938!RIV14-MZ0-00064165" . "P\u0159\u00EDpad pacientky s roztrou\u0161enou skler\u00F3zou diagnostikovanou v roce 1996 upozor\u0148uje na vliv pozdn\u00EDho zah\u00E1jen\u00ED l\u00E9\u010Dby biologickou l\u00E9\u010Dbou na progn\u00F3zu pacientky. L\u00E9\u010Dba interferonem beta zah\u00E1jen\u00E1 po v\u00EDce ne\u017E 10 letech imuniosupresivn\u00ED l\u00E9\u010Dby v\u010Detn\u011B pulzn\u00EDho pod\u00E1v\u00E1n\u00ED cyklofosfamidu a mitoxantronu byla zcela neefektivn\u00ED. Z\u00E1n\u011Btliv\u00E1 aktivita pokra\u010Dovala a pacentka byla posl\u00E9ze p\u0159evedena na eskala\u010Dn\u00ED l\u00E9\u010Dbu natalizumabem P\u0159esto\u017Ee pr\u016Fb\u011Bh choroby by na prvn\u00ED pohled bylo mo\u017En\u00E9 v t\u00E9 dob\u011B hodnotit i jako sekund\u00E1rn\u011B progresivn\u00ED, av\u0161ak s je\u0161t\u011B zachovanou z\u00E1n\u011Btlivou aktivitou nemoci, do\u0161lo ji\u017E b\u011Bhem prvn\u00EDho roku l\u00E9\u010Dby natalizumabem ke zlep\u0161en\u00ED o dva stupn\u011B Kurtzkeho \u0161k\u00E1ly disability."@cs . "Supplement 1" . . "1210-7859" . . . . . "1"^^ . . "Havrdov\u00E1, Eva" . "Interferon Beta Therapy Initiation at an Inappropriate Phase of the Disease"@en . "[09ADE4862D92]" . "000325235000012" . "76/109" . "RIV/00064165:_____/13:10188938" . "1"^^ . . "http://www.prolekare.cz/dokumenty/j48_2013_csnn_supplementum.pdf" . "natalizumab; interferon beta; Multiple sclerosis"@en . . "I, Z(MSM0021620849)" . "3"^^ .