"978-80-247-3727-0" . "RIV/00064165:_____/12:13527" . . . . . . . . "Rituximab; Rituxan, MabThera; chimeric antibody; human immunoglobulin; Alemtuzumab; MabCampath; CD52 antigen; B-lymphocytes; T-lymphocytes; mature granulocytes; Gemtuzumab ozogamicin; Mylotarg; anti-CD33 antibody; Ibritumomab tiuxetan; Zevalin; anti-CD20 antibody; Ofatumumab; Arzerra"@en . . "Biologick\u00E1 l\u00E9\u010Diva : teoretick\u00E9 z\u00E1klady a klinick\u00E1 praxe" . . "11"^^ . "228"^^ . . . . . . . . "[65AD910A590B]" . "Grada Publishing" . "1"^^ . . . . . "RIV/00064165:_____/12:13527!RIV13-MZ0-00064165" . "Biological drugs in hematooncology"@en . . "125103" . "1"^^ . "Biologick\u00E1 l\u00E9\u010Diva v hematoonkologii"@cs . "Pytl\u00EDk, Robert" . "Biologick\u00E1 l\u00E9\u010Diva v hematoonkologii"@cs . "Rituximab is one of the first monoclonal antibodies that have penetrated into clinical use. It is a chimeric antibody, where the heavy chain and the constatnt part of light chain consists of human immunoglobulin, while the variable light chain is of mouse origin ... Alemtuzumab is a humanized antibody against the CD52 antigen. This antigen is present on B and T lymphocytes, but also on mature granulocytes ... Gemtuzumab ozogamicin is an anti-CD33 antibody with bonded enediyn antibiotic kalicheamycin ... Ibritumomab tiuxetan is an anti-CD20 antibody with chelator, through which it is possible to conjugate it with the radioactive isotope ... Ofatumumab is a fully human anti-CD20 antibody ..."@en . . . . "Rituximab je jednou z prvn\u00EDch monoklon\u00E1ln\u00EDch protil\u00E1tek, kter\u00E9 pronikly do klinick\u00E9ho u\u017Eit\u00ED. Jde o chim\u00E9rickou protil\u00E1tku, kde t\u011B\u017Ek\u00FD \u0159etezec a konstatntn\u00ED \u010D\u00E1st lehk\u00E9ho \u0159et\u011Bzce je tvo\u0159ena lidsk\u00FDm imunoglobulinem, zat\u00EDmco variabiln\u00ED \u010D\u00E1st lehk\u00FDch \u0159et\u011Bzc\u016F je my\u0161\u00EDho p\u016Fvodu... Alemtuzumab je humanizovan\u00E1 protil\u00E1tka proti antigenu CD52. Tento antigen je p\u0159\u00EDtomen na B i T-lymfocytech, ale i na zral\u00FDch granulocytech... Gemtuzumab ozogamicin je anti-CD33 protil\u00E1tka s nav\u00E1zan\u00FDm enediynov\u00FDm antibiotikem kalicheamycinem... Ibritumomab tiuxetan je anti-CD20 protil\u00E1tka s chel\u00E1torem, s jeho\u017E pomoc\u00ED je ji mo\u017En\u00E9 konjugovat s radioaktivn\u00EDm izotopem... Ofatumumab je pln\u011B hum\u00E1nn\u00ED anti-CD20 protil\u00E1tka..." . "Biologick\u00E1 l\u00E9\u010Diva v hematoonkologii" . . . "N" . . . "Praha" . . . "Rituximab je jednou z prvn\u00EDch monoklon\u00E1ln\u00EDch protil\u00E1tek, kter\u00E9 pronikly do klinick\u00E9ho u\u017Eit\u00ED. Jde o chim\u00E9rickou protil\u00E1tku, kde t\u011B\u017Ek\u00FD \u0159etezec a konstatntn\u00ED \u010D\u00E1st lehk\u00E9ho \u0159et\u011Bzce je tvo\u0159ena lidsk\u00FDm imunoglobulinem, zat\u00EDmco variabiln\u00ED \u010D\u00E1st lehk\u00FDch \u0159et\u011Bzc\u016F je my\u0161\u00EDho p\u016Fvodu... Alemtuzumab je humanizovan\u00E1 protil\u00E1tka proti antigenu CD52. Tento antigen je p\u0159\u00EDtomen na B i T-lymfocytech, ale i na zral\u00FDch granulocytech... Gemtuzumab ozogamicin je anti-CD33 protil\u00E1tka s nav\u00E1zan\u00FDm enediynov\u00FDm antibiotikem kalicheamycinem... Ibritumomab tiuxetan je anti-CD20 protil\u00E1tka s chel\u00E1torem, s jeho\u017E pomoc\u00ED je ji mo\u017En\u00E9 konjugovat s radioaktivn\u00EDm izotopem... Ofatumumab je pln\u011B hum\u00E1nn\u00ED anti-CD20 protil\u00E1tka..."@cs . "Biologick\u00E1 l\u00E9\u010Diva v hematoonkologii" . . "Biological drugs in hematooncology"@en .