"The aim of this article is to give an overview of current status of worldwide discussion of effectivness of Down\u2019s syndrome screeening programs. This article explaines structure of basic screening strategies and review of their published evidence. In this article screening tests of the first trimester (combined test with or without new sonographic markers), the second trimester (quadruple, triple and double test) and tests which combine markes of the first trimester with markers of the second trimester (integrated test, sequential test and contingent tests) are discussed. Arguments supporting current trend to perform screening in the first trimester with combination ultrasound and biochemical markers of the first trimester are discussed."@en . . "RIV/00064165:_____/12:13340" . "Down syndrome screening in the first, second or both trimesters?"@en . "C\u00EDlem \u010Dl\u00E1nku je podat odborn\u00E9 ve\u0159ejnosti p\u0159ehled sou\u010Dasn\u00E9ho stavu celosv\u011Btov\u00E9 diskuze o tom, kter\u00FD screeningov\u00FD program pro Down\u016Fv syndrom se jev\u00ED jako nejefektivn\u011Bj\u0161\u00ED. \u010Cl\u00E1nek uv\u00E1d\u00ED p\u0159ehled hlavn\u00EDch screeningov\u00FDch strategi\u00ED, strukturu jednotliv\u00FDch test\u016F a diskuzi o evidenci, kter\u00E1 je o nich publikov\u00E1na. V \u010Dl\u00E1nku jsou diskutov\u00E1ny screeningov\u00E9 programy prvn\u00EDho trimestru (kombinovan\u00FD test, kontingen\u010Dn\u00ED test v prvn\u00EDm trimestru), druh\u00E9ho trimestru (quadruple, triple, double test) i programy kombinuj\u00EDc\u00ED prvn\u00ED a druh\u00FD trimestr (integrovan\u00FD test, sekven\u010Dn\u00ED test, kontingen\u010Dn\u00ED testy). \u010Cl\u00E1nek podrobn\u011B rozeb\u00EDr\u00E1 d\u016Fvody podporuj\u00EDc\u00ED sou\u010Dasn\u00FD p\u0159\u00EDklon k screeningu v prvn\u00EDm trimestru, kter\u00FD kombinuje ultrazvukov\u00E9 vy\u0161et\u0159en\u00ED a biochemick\u00E9 vy\u0161et\u0159en\u00ED s\u00E9ra t\u011Bhotn\u00E9, tedy kombinovan\u00FD test a kontingen\u010Dn\u00ED test v prvn\u00EDm trimestru"@cs . . "Down syndrome screening in the first, second or both trimesters?"@en . "8"^^ . "1803-9588" . . . "C\u00EDlem \u010Dl\u00E1nku je podat odborn\u00E9 ve\u0159ejnosti p\u0159ehled sou\u010Dasn\u00E9ho stavu celosv\u011Btov\u00E9 diskuze o tom, kter\u00FD screeningov\u00FD program pro Down\u016Fv syndrom se jev\u00ED jako nejefektivn\u011Bj\u0161\u00ED. \u010Cl\u00E1nek uv\u00E1d\u00ED p\u0159ehled hlavn\u00EDch screeningov\u00FDch strategi\u00ED, strukturu jednotliv\u00FDch test\u016F a diskuzi o evidenci, kter\u00E1 je o nich publikov\u00E1na. V \u010Dl\u00E1nku jsou diskutov\u00E1ny screeningov\u00E9 programy prvn\u00EDho trimestru (kombinovan\u00FD test, kontingen\u010Dn\u00ED test v prvn\u00EDm trimestru), druh\u00E9ho trimestru (quadruple, triple, double test) i programy kombinuj\u00EDc\u00ED prvn\u00ED a druh\u00FD trimestr (integrovan\u00FD test, sekven\u010Dn\u00ED test, kontingen\u010Dn\u00ED testy). \u010Cl\u00E1nek podrobn\u011B rozeb\u00EDr\u00E1 d\u016Fvody podporuj\u00EDc\u00ED sou\u010Dasn\u00FD p\u0159\u00EDklon k screeningu v prvn\u00EDm trimestru, kter\u00FD kombinuje ultrazvukov\u00E9 vy\u0161et\u0159en\u00ED a biochemick\u00E9 vy\u0161et\u0159en\u00ED s\u00E9ra t\u011Bhotn\u00E9, tedy kombinovan\u00FD test a kontingen\u010Dn\u00ED test v prvn\u00EDm trimestru" . . "Belo\u0161ovi\u010Dov\u00E1, Hana" . . "[DC52549CD8E0]" . "Down syndrome; screening strategies; efficiency; combined test; integrated test; biochemical screening; ultrasound; prenatal diagnostics"@en . . "Screening Downova syndromu v prvn\u00EDm, druh\u00E9m nebo obou trimestrech?"@cs . "RIV/00064165:_____/12:13340!RIV13-MZ0-00064165" . . . . . "Screening Downova syndromu v prvn\u00EDm, druh\u00E9m nebo obou trimestrech?" . "4" . "4" . . . . "Screening Downova syndromu v prvn\u00EDm, druh\u00E9m nebo obou trimestrech?"@cs . . . "2"^^ . . "CZ - \u010Cesk\u00E1 republika" . "Screening Downova syndromu v prvn\u00EDm, druh\u00E9m nebo obou trimestrech?" . "Aktu\u00E1ln\u00ED gynekologie a porodnictv\u00ED" . "Calda, Pavel" . . "http://www.actualgyn.com/pdf/cz_2012_67.pdf" . "166894" . "2"^^ . . "I" . . .