"Burgetov\u00E1, Andrea" . . . . "RIV/00064165:_____/12:12063" . . . . "M\u011B\u0159en\u00ED atrofie corpus callosum a porovn\u00E1n\u00ED s ostatn\u00EDmi metodami monitorace roztrou\u0161en\u00E9 skler\u00F3zy"@cs . . . . . . . . "1210-7859" . "\u010Cesk\u00E1 a slovensk\u00E1 neurologie a neurochirurgie" . "Aim: To compare contemporary MRI measures for prediction of future clinical disability in multiple sclerosis patients (MS) by analysis of our MRI data (brain atrophy, 12 lesion volume, T1 lesion volume and corpus callosum atrophy). Methods: Long-term (seven years) longitudinal MRI data of 178 patients were analyzed in the same protocol: FLAIR and T1 WI 3D. Using an originally developed software named ScanViewCZ (developed at our MR unit), lesion load was measured automatically from FLAIR sequence (T2 lesion volume), the brain atrophy, brain parenchymal fraction and T1 lesion volume were assed from T1W 3D sequence. Measurement of corpus callosum atrophy: area of the central slice in sagittal reconstruction of T1 W 3D was determined automatically by the originally developed software. Clinical disability was assessed with Expanded Disability Status Scale (EDSS). Patients were divided into two groups: clinically stable and those with sustained progression over seven years. Results: Statistically significant correlation of future sustained disability progression (as characterized by EDSS score) was found in association with brain atrophy and corpus callosum atrophy. Correlation with lesion load was low. Using the corpus callosum MRI, clinically stable patients were statistically significantly (p = 0.0024) different from patients with sustained progression as soon as within the first year. Conclusions: This retrospective study shows that monitoring of the corpus callosum atrophy is the most useful for stratification of patients into %22stable%22 and %22sustained progression%22 groups."@en . "RIV/00064165:_____/12:12063!RIV13-MZ0-00064165" . "[C61764CC87F4]" . "Measurement of Corpus Callosum and Comparison of MRI Techniques for Monitoring of Multiple Sclerosis"@en . . "Van\u011B\u010Dkov\u00E1, Manuela" . "Hor\u00E1kov\u00E1, Dana" . "6" . . . "149370" . . . "Kr\u00E1sensk\u00FD, Jan" . "Measurement of Corpus Callosum and Comparison of MRI Techniques for Monitoring of Multiple Sclerosis"@en . . "I, Z(MSM0021620849)" . "M\u011B\u0159en\u00ED atrofie corpus callosum a porovn\u00E1n\u00ED s ostatn\u00EDmi metodami monitorace roztrou\u0161en\u00E9 skler\u00F3zy" . "Havrdov\u00E1, Eva" . "6"^^ . . . "Seidl, Zden\u011Bk" . "M\u011B\u0159en\u00ED atrofie corpus callosum a porovn\u00E1n\u00ED s ostatn\u00EDmi metodami monitorace roztrou\u0161en\u00E9 skler\u00F3zy"@cs . "7"^^ . "C\u00EDl: Hled\u00E1n\u00ED nejvhodn\u011Bj\u0161\u00EDho markeru na odli\u0161en\u00ED pacient\u016F s roztrou\u0161enou skler\u00F3zou (RS), u kter\u00FDch v budoucnu dojde k zhor\u0161en\u00ED klinick\u00E9ho stavu (sustained progression), od pacient\u016F dlohodob\u011B stabiln\u00EDch. Soubor a metodika:Dlouhodob\u00E9 sledov\u00E1n\u00ED (sedm let) 178 pacient\u016F s RS. Na MR byli vy\u0161et\u0159eni ve stejn\u00E9m MR protokolu (v sekvenci FLAIR a T1W/3D obraze). Byl zji\u0161\u0165ov\u00E1n T2 objem lo\u017Eisek, T1 objem lo\u017Eisek, atrofie mozku a m\u011B\u0159en\u00ED atrofie corpus callosum. M\u011B\u0159en\u00ED byla prov\u00E1d\u011Bna pomoc\u00ED programu vyvinut\u00E9ho na na\u0161em pracovi\u0161ti (ScanViewCZ). Klinick\u00FD stav byl ur\u010Den dle roz\u0161\u00ED\u0159en\u00E9 stupnice m\u00EDry klinick\u00E9ho posti\u017Een\u00ED (ADSS sk\u00F3re). P\u0159i retrospektivn\u00ED studii byli pacienti rozd\u011Bleni do dvou skupin: klinicky stabiln\u00ED a pacienty, u kter\u00FDch do\u0161lo k trval\u00E9mu zhor\u0161en\u00ED klinick\u00E9ho stavu(zhor\u0161en\u00ED bylo p\u0159esn\u011B definov\u00E1no-susteined progression). Klinicky stabiln\u00EDch bylo po dobu sledov\u00E1n\u00ED sedmi let 82 pacient\u016F, 96 pacient\u016F dos\u00E1hlo sustained progression. V\u00FDsledky:Statisticky signifikantn\u00ED korelace mezi budouc\u00EDm klinick\u00FDm stavem a MR m\u011B\u0159en\u00EDm byla nalezena pro m\u011B\u0159en\u00ED mozkov\u00E9 atrofie a atrofie corpus callosum. Korelace T2 objemu lo\u017Eisek i T1 objemu lo\u017Eisek byla ni\u017E\u0161\u00ED, rozli\u0161en\u00ED obou skupin dle velikosti objemu lo\u017Eisek bylo statisticky v\u00FDznamn\u00E9 ji\u017E p\u0159i vstupn\u00EDm vy\u0161et\u0159en\u00ED, jistota ur\u010Den\u00ED skupiny se v pr\u016Fb\u011Bhu dal\u0161\u00EDho sledov\u00E1n\u00ED v\u0161ak jen m\u00EDrn\u011B zvy\u0161ovala. Nejrobustn\u011Bji odli\u0161ilo ob\u011B skupiny m\u011B\u0159en\u00ED atrofie corpus callosum, ji\u017E v prvn\u00EDm roce se ob\u011B skupiny od sebe li\u0161\u00ED statisticky v\u00FDznamn\u011B (p=0,0024). Z\u00E1v\u011Br: Tato pr\u00E1ce ukazuje, \u017Ee m\u011B\u0159en\u00ED atrofie corpus callosum je z hlediska odli\u0161en\u00ED pacient\u016F, kte\u0159\u00ED se v budoucnu zhor\u0161\u00ED, od t\u011Bch klinicky stabiln\u00EDch nejp\u0159\u00EDnosn\u011Bj\u0161\u00ED, \u010Dasn\u00E9 vymezen\u00ED m\u00E1 velk\u00FD v\u00FDznam pro ur\u010Den\u00ED pacient\u016F, u kter\u00FDch by m\u011Blo doj\u00EDt k eskalaci l\u00E9\u010Dby." . . "C\u00EDl: Hled\u00E1n\u00ED nejvhodn\u011Bj\u0161\u00EDho markeru na odli\u0161en\u00ED pacient\u016F s roztrou\u0161enou skler\u00F3zou (RS), u kter\u00FDch v budoucnu dojde k zhor\u0161en\u00ED klinick\u00E9ho stavu (sustained progression), od pacient\u016F dlohodob\u011B stabiln\u00EDch. Soubor a metodika:Dlouhodob\u00E9 sledov\u00E1n\u00ED (sedm let) 178 pacient\u016F s RS. Na MR byli vy\u0161et\u0159eni ve stejn\u00E9m MR protokolu (v sekvenci FLAIR a T1W/3D obraze). Byl zji\u0161\u0165ov\u00E1n T2 objem lo\u017Eisek, T1 objem lo\u017Eisek, atrofie mozku a m\u011B\u0159en\u00ED atrofie corpus callosum. M\u011B\u0159en\u00ED byla prov\u00E1d\u011Bna pomoc\u00ED programu vyvinut\u00E9ho na na\u0161em pracovi\u0161ti (ScanViewCZ). Klinick\u00FD stav byl ur\u010Den dle roz\u0161\u00ED\u0159en\u00E9 stupnice m\u00EDry klinick\u00E9ho posti\u017Een\u00ED (ADSS sk\u00F3re). P\u0159i retrospektivn\u00ED studii byli pacienti rozd\u011Bleni do dvou skupin: klinicky stabiln\u00ED a pacienty, u kter\u00FDch do\u0161lo k trval\u00E9mu zhor\u0161en\u00ED klinick\u00E9ho stavu(zhor\u0161en\u00ED bylo p\u0159esn\u011B definov\u00E1no-susteined progression). Klinicky stabiln\u00EDch bylo po dobu sledov\u00E1n\u00ED sedmi let 82 pacient\u016F, 96 pacient\u016F dos\u00E1hlo sustained progression. V\u00FDsledky:Statisticky signifikantn\u00ED korelace mezi budouc\u00EDm klinick\u00FDm stavem a MR m\u011B\u0159en\u00EDm byla nalezena pro m\u011B\u0159en\u00ED mozkov\u00E9 atrofie a atrofie corpus callosum. Korelace T2 objemu lo\u017Eisek i T1 objemu lo\u017Eisek byla ni\u017E\u0161\u00ED, rozli\u0161en\u00ED obou skupin dle velikosti objemu lo\u017Eisek bylo statisticky v\u00FDznamn\u00E9 ji\u017E p\u0159i vstupn\u00EDm vy\u0161et\u0159en\u00ED, jistota ur\u010Den\u00ED skupiny se v pr\u016Fb\u011Bhu dal\u0161\u00EDho sledov\u00E1n\u00ED v\u0161ak jen m\u00EDrn\u011B zvy\u0161ovala. Nejrobustn\u011Bji odli\u0161ilo ob\u011B skupiny m\u011B\u0159en\u00ED atrofie corpus callosum, ji\u017E v prvn\u00EDm roce se ob\u011B skupiny od sebe li\u0161\u00ED statisticky v\u00FDznamn\u011B (p=0,0024). Z\u00E1v\u011Br: Tato pr\u00E1ce ukazuje, \u017Ee m\u011B\u0159en\u00ED atrofie corpus callosum je z hlediska odli\u0161en\u00ED pacient\u016F, kte\u0159\u00ED se v budoucnu zhor\u0161\u00ED, od t\u011Bch klinicky stabiln\u00EDch nejp\u0159\u00EDnosn\u011Bj\u0161\u00ED, \u010Dasn\u00E9 vymezen\u00ED m\u00E1 velk\u00FD v\u00FDznam pro ur\u010Den\u00ED pacient\u016F, u kter\u00FDch by m\u011Blo doj\u00EDt k eskalaci l\u00E9\u010Dby."@cs . . . . "Multiple sclerosis; magnetic resonance imaging; corpus callosum; monitoring; disability progression; white-matter; gray-matter; atrophy; ms"@en . . "Ma\u0161ek, Martin" . "7"^^ . . "75" . . "000311242700011" . "M\u011B\u0159en\u00ED atrofie corpus callosum a porovn\u00E1n\u00ED s ostatn\u00EDmi metodami monitorace roztrou\u0161en\u00E9 skler\u00F3zy" . "CZ - \u010Cesk\u00E1 republika" . .