"134580" . . "V" . . "1"^^ . . . . "Enzymy pro l\u00E9\u010Dbu d\u011Bdi\u010Dn\u011B podm\u00EDn\u011Bn\u00FDch poruch intermedi\u00E1rn\u00EDho metabolismu" . "1"^^ . . "Praha" . . "RIV/00064165:_____/12:11883!RIV13-MZ0-00064165" . . . "Biotechnologic technology is often used in medicine for production of so called recombinant enzymes. These enzymes are after purification and chemical modification administered to patients with lysozomal storage diseases caused by deficient activity of relevant enzyme. On this basis it is possible to reduce or correct a lot of visceral or skeletal manifastation of the disease."@en . . . . "228"^^ . . "biologic drugs; enzymes; lysozomal storage diseases; visceral manifastation; skeletal manifastation"@en . "Biologick\u00E1 l\u00E9\u010Diva : teoretick\u00E9 z\u00E1klady a klinick\u00E1 praxe" . "Enzymes for therapy of inherited metabolic disorders"@en . "978-80-247-3727-0" . "RIV/00064165:_____/12:11883" . "U lysozom\u00E1ln\u00EDch st\u0159\u00E1dav\u00FDch onemocn\u011Bn\u00ED vyu\u017E\u00EDv\u00E1me biotechnologick\u00FDch technologi\u00ED k v\u00FDrob\u011B tzv. rekombinantn\u00EDch enzym\u016F, kter\u00E9 je po purifikaci a chemick\u00E9 \u00FAprav\u011B mo\u017Eno aplikovat nemocn\u00FDm, u nich\u017E je aktivita dan\u00E9ho enzymu nedostate\u010Dn\u00E1. Na tomto podklad\u011B je mo\u017Eno korigovat celou \u0159adu viscer\u00E1ln\u00EDch \u010Di skelet\u00E1ln\u00EDch patologi\u00ED u st\u0159\u00E1dav\u00FDch onemocn\u011Bn\u00ED."@cs . "Enzymes for therapy of inherited metabolic disorders"@en . "Grada" . . "Enzymy pro l\u00E9\u010Dbu d\u011Bdi\u010Dn\u011B podm\u00EDn\u011Bn\u00FDch poruch intermedi\u00E1rn\u00EDho metabolismu"@cs . "[11DBC5FC0093]" . "7"^^ . "U lysozom\u00E1ln\u00EDch st\u0159\u00E1dav\u00FDch onemocn\u011Bn\u00ED vyu\u017E\u00EDv\u00E1me biotechnologick\u00FDch technologi\u00ED k v\u00FDrob\u011B tzv. rekombinantn\u00EDch enzym\u016F, kter\u00E9 je po purifikaci a chemick\u00E9 \u00FAprav\u011B mo\u017Eno aplikovat nemocn\u00FDm, u nich\u017E je aktivita dan\u00E9ho enzymu nedostate\u010Dn\u00E1. Na tomto podklad\u011B je mo\u017Eno korigovat celou \u0159adu viscer\u00E1ln\u00EDch \u010Di skelet\u00E1ln\u00EDch patologi\u00ED u st\u0159\u00E1dav\u00FDch onemocn\u011Bn\u00ED." . "Malinov\u00E1, V\u011Bra" . . . "Enzymy pro l\u00E9\u010Dbu d\u011Bdi\u010Dn\u011B podm\u00EDn\u011Bn\u00FDch poruch intermedi\u00E1rn\u00EDho metabolismu" . "Enzymy pro l\u00E9\u010Dbu d\u011Bdi\u010Dn\u011B podm\u00EDn\u011Bn\u00FDch poruch intermedi\u00E1rn\u00EDho metabolismu"@cs . .