. "MikroRNA a jejich potenci\u00E1l v diagnostice karcinomu ovaria: sou\u010Dasn\u00FD stav a mo\u017En\u00E1 budoucnost" . "Z\u00E1vesk\u00FD, Lud\u011Bk" . "150536" . . . "adenocarcinoma; markers of adenocarcinoma; microRNA; diagnostics of ovarian cancer; ovarian cancer"@en . . . "Epithelial ovarian cancer is the most fatal gynecologic cancer. Recent studies suggest an extraovarian origin for this disease. However, there is lack of information on exact etiology of ovarian cancer, and screening markers are also lacking. Non-coding RNA, particularly microRNAs are currently intensively investigated. They may be implicated in various cellular processes and regulate the gene expression at post-transcriptional level. In carcinogenesis, they may be involved as well, e.g. as tumor suppressors, or oncogenes. There have been identifi ed expression profi les of microRNAs for various types of samples in ovarian cancer, however no expression profi le is currently available for use in clinical diagnosis of ovarian cancer. Analyses of non-invasively collected material (e.g. urine, saliva) and further analyses of serum, or blood may provide basis for establishment of better diagnostic tools. We reviewed the studies on microRNAs shown to be deregulated in ovarian cancer, and coming from tumor tissues, plasma exosomes, serum, whole blood, and diff ering also between recurrent vs. primary ovarian cancer tissues. Function of particular microRNA is known partially only in several cases; however, for many microRNAs an elucidation of their functional role remains the goal for future investigations. MicroRNAs thus may stand at the beginning of novel diagnostic and therapeutic tools for ovarian ancer and other malignancies."@en . "CZ - \u010Cesk\u00E1 republika" . "Praktick\u00E1 gynekologie" . . "MikroRNA a jejich potenci\u00E1l v diagnostice karcinomu ovaria: sou\u010Dasn\u00FD stav a mo\u017En\u00E1 budoucnost"@cs . "2"^^ . "1211-6645" . "http://www.praktickagynekologie.cz/prakticka-gynekologie-clanek/mikrorna-a-jejich-potencial-v-diagnostice-karcinomu-ovaria-soucasny-stav-a-mozna-budoucnost-39738" . . "RIV/00064165:_____/12:00013605" . "7"^^ . . . "3"^^ . "MikroRNA a jejich potenci\u00E1l v diagnostice karcinomu ovaria: sou\u010Dasn\u00FD stav a mo\u017En\u00E1 budoucnost" . "Karcinom ovaria je nejzhoubn\u011Bj\u0161\u00EDm gynekologick\u00FDm n\u00E1dorem. Nejnov\u011Bj\u0161\u00ED v\u00FDzkumy ukazuj\u00ED, \u017Ee v ovari\u00E1ln\u00ED karcinogenezi hraj\u00ED v\u00FDznamnou roli extraovari\u00E1ln\u00ED tk\u00E1n\u011B. P\u0159esto nen\u00ED p\u0159esn\u00E1 etiologie karcinomu ovaria zn\u00E1ma a dosud neexistuje screeningov\u00FD marker pro z\u00E1chyt nemoci v \u010Dasn\u00E9m stadiu. Velk\u00E1 pozornost sou\u010Dasn\u00E9ho v\u00FDzkumu je v\u011Bnov\u00E1na nek\u00F3duj\u00EDc\u00EDm RNA, p\u0159edev\u0161\u00EDm mikroRNA. Tyto molekuly mohou regulovat expresi gen\u016F na posttranskrip\u010Dn\u00ED \u00FArovni a uplat\u0148uj\u00ED se v \u0159ad\u011B bun\u011B\u010Dn\u00FDch proces\u016F. V karcinogenezi se mohou uplat\u0148ovat tak\u00E9 jako regula\u010Dn\u00ED faktory, nap\u0159. v roli tumor-supresor\u016F i onkogen\u016F. U karcinomu ovaria byly identifikov\u00E1ny profily exprese r\u016Fzn\u00FDch mikroRNA pro r\u016Fzn\u00E9 typy vzork\u016F. V sou\u010Dasnosti v\u0161ak neexistuje konsenzu\u00E1ln\u00ED profil exprese mikroRNA, pou\u017Eiteln\u00FD pro klinickou diagnostiku karcinomu ovaria. Diagnostick\u00FD v\u00FDznam exprese mikroRNA v budoucnosti vzroste s rozvojem anal\u00FDz neinvazivn\u011B odeb\u00EDran\u00E9ho materi\u00E1lu (nap\u0159. mo\u010Di, slin) a dal\u0161\u00EDch anal\u00FDz s\u00E9ra a krve. V tomto \u010Dl\u00E1nku uv\u00E1d\u00EDme p\u0159ehled deregulovan\u00FDch mikroRNA, identifikovan\u00FDch v recentn\u00EDch v\u00FDzkumech karcinomu ovaria, zahrnuj\u00EDc\u00EDch tk\u00E1n\u011B, exozomy, s\u00E9rum a plnou krev, a tak\u00E9 nalezen\u00FDch jako deregulovan\u00E9 u recidivuj\u00EDc\u00EDch karcinom\u016F ovaria. U n\u011Bkter\u00FDch mikroRNA jsou ur\u010Dit\u00E9 funkce \u010D\u00E1ste\u010Dn\u011B zn\u00E1my, ale u mnoh\u00FDch je objasn\u011Bn\u00ED jejich funkce v ovari\u00E1ln\u00ED karcinogenezi ot\u00E1zkou pro budouc\u00ED v\u00FDzkumy. MikroRNA tak maj\u00ED velk\u00FD potenci\u00E1l st\u00E1t na po\u010D\u00E1tku nov\u00FDch diagnostick\u00FDch a terapeutick\u00FDch postup\u016F u karcinomu ovaria i jin\u00FDch n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED." . "I" . "16" . "Kohoutov\u00E1, Milada" . . . "MicroRNA and their potential in ovarian cancer diagnostics: Current state and possible future"@en . "RIV/00064165:_____/12:00013605!RIV14-MZ0-00064165" . . "Jand\u00E1kov\u00E1, Eva" . "2-4" . "MikroRNA a jejich potenci\u00E1l v diagnostice karcinomu ovaria: sou\u010Dasn\u00FD stav a mo\u017En\u00E1 budoucnost"@cs . . . "Karcinom ovaria je nejzhoubn\u011Bj\u0161\u00EDm gynekologick\u00FDm n\u00E1dorem. Nejnov\u011Bj\u0161\u00ED v\u00FDzkumy ukazuj\u00ED, \u017Ee v ovari\u00E1ln\u00ED karcinogenezi hraj\u00ED v\u00FDznamnou roli extraovari\u00E1ln\u00ED tk\u00E1n\u011B. P\u0159esto nen\u00ED p\u0159esn\u00E1 etiologie karcinomu ovaria zn\u00E1ma a dosud neexistuje screeningov\u00FD marker pro z\u00E1chyt nemoci v \u010Dasn\u00E9m stadiu. Velk\u00E1 pozornost sou\u010Dasn\u00E9ho v\u00FDzkumu je v\u011Bnov\u00E1na nek\u00F3duj\u00EDc\u00EDm RNA, p\u0159edev\u0161\u00EDm mikroRNA. Tyto molekuly mohou regulovat expresi gen\u016F na posttranskrip\u010Dn\u00ED \u00FArovni a uplat\u0148uj\u00ED se v \u0159ad\u011B bun\u011B\u010Dn\u00FDch proces\u016F. V karcinogenezi se mohou uplat\u0148ovat tak\u00E9 jako regula\u010Dn\u00ED faktory, nap\u0159. v roli tumor-supresor\u016F i onkogen\u016F. U karcinomu ovaria byly identifikov\u00E1ny profily exprese r\u016Fzn\u00FDch mikroRNA pro r\u016Fzn\u00E9 typy vzork\u016F. V sou\u010Dasnosti v\u0161ak neexistuje konsenzu\u00E1ln\u00ED profil exprese mikroRNA, pou\u017Eiteln\u00FD pro klinickou diagnostiku karcinomu ovaria. Diagnostick\u00FD v\u00FDznam exprese mikroRNA v budoucnosti vzroste s rozvojem anal\u00FDz neinvazivn\u011B odeb\u00EDran\u00E9ho materi\u00E1lu (nap\u0159. mo\u010Di, slin) a dal\u0161\u00EDch anal\u00FDz s\u00E9ra a krve. V tomto \u010Dl\u00E1nku uv\u00E1d\u00EDme p\u0159ehled deregulovan\u00FDch mikroRNA, identifikovan\u00FDch v recentn\u00EDch v\u00FDzkumech karcinomu ovaria, zahrnuj\u00EDc\u00EDch tk\u00E1n\u011B, exozomy, s\u00E9rum a plnou krev, a tak\u00E9 nalezen\u00FDch jako deregulovan\u00E9 u recidivuj\u00EDc\u00EDch karcinom\u016F ovaria. U n\u011Bkter\u00FDch mikroRNA jsou ur\u010Dit\u00E9 funkce \u010D\u00E1ste\u010Dn\u011B zn\u00E1my, ale u mnoh\u00FDch je objasn\u011Bn\u00ED jejich funkce v ovari\u00E1ln\u00ED karcinogenezi ot\u00E1zkou pro budouc\u00ED v\u00FDzkumy. MikroRNA tak maj\u00ED velk\u00FD potenci\u00E1l st\u00E1t na po\u010D\u00E1tku nov\u00FDch diagnostick\u00FDch a terapeutick\u00FDch postup\u016F u karcinomu ovaria i jin\u00FDch n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED."@cs . . . "[B9B98E2F4168]" . "MicroRNA and their potential in ovarian cancer diagnostics: Current state and possible future"@en . . .