. "RIV/00064165:_____/11:9834" . "Chromogranin A (CgA) is a hydrophilic acidic one-chain peptide containing 439 amino acids, preceded by NH(2)-terminal 18-amino-acid signal peptide; the complete pre-chromogranin A molecule thus encompasses 457 amino acids. It is a member of the chromogranin family that comprises several proteins. The CgA gene is a single-copy gene localized in the locus 14q32. Chromogranin A is produced by endocrine and neuroendocrine cells. The largest amount of CgA occurs in chromaffin granules of adrenal medulla and in the dense-core vesicles of sympathetic nerves. Its biological functions have not been completely elucidated, but it is known that it acts as a precursor of many biologically active peptides generated by cleavage at specific sites. It is the major soluble protein co-stored and co-released along with resident catecholamines and polypeptide hormones or cell-specific neurotransmitters. Because of its widespread distribution in neuroendocrine tissue, it can be used both as immunohistochemical marker and serum marker of neuroendocrine tumours. CgA has been used as a rather reliable tumour marker because its level is significantly increased in neuroendocrine tumours and changes of its level reflect the tumour response to therapy or tumour recurrence." . . . "Chromogranin A in Physiology and Oncology"@en . . . . "0015-5500" . . . . . . "CZ - \u010Cesk\u00E1 republika" . . . "1"^^ . "chromogranin; neuroendocrine tumours; cleavage fragments; extracellular functions; intracellular functions; tumour marker; neuroendocrine tumors; immunoradiometric assay; diagnosis; markers; pheochromocytoma; endocrine; fragments; neoplasia; granules; release"@en . . "[205CFCD17F9C]" . . "000297182800001" . . "5" . . "1"^^ . . . "Folia Biologica" . . "Chromogranin A in Physiology and Oncology" . . . "I, Z(MSM0021620808)" . "Chromogranin A in Physiology and Oncology" . "RIV/00064165:_____/11:9834!RIV12-MZ0-00064165" . . "57" . . . "9"^^ . . . "http://fb.cuni.cz/file/5597/FB2011A0026.pdf" . "190335" . . . "Chromogranin A in Physiology and Oncology"@en . "Chromogranin A (CgA) is a hydrophilic acidic one-chain peptide containing 439 amino acids, preceded by NH(2)-terminal 18-amino-acid signal peptide; the complete pre-chromogranin A molecule thus encompasses 457 amino acids. It is a member of the chromogranin family that comprises several proteins. The CgA gene is a single-copy gene localized in the locus 14q32. Chromogranin A is produced by endocrine and neuroendocrine cells. The largest amount of CgA occurs in chromaffin granules of adrenal medulla and in the dense-core vesicles of sympathetic nerves. Its biological functions have not been completely elucidated, but it is known that it acts as a precursor of many biologically active peptides generated by cleavage at specific sites. It is the major soluble protein co-stored and co-released along with resident catecholamines and polypeptide hormones or cell-specific neurotransmitters. Because of its widespread distribution in neuroendocrine tissue, it can be used both as immunohistochemical marker and serum marker of neuroendocrine tumours. CgA has been used as a rather reliable tumour marker because its level is significantly increased in neuroendocrine tumours and changes of its level reflect the tumour response to therapy or tumour recurrence."@en . . "Louthan, Old\u0159ich" .