"7"^^ . . . . "5"^^ . . "44" . . . "RIV/00064165:_____/11:9362" . "Association of pregnancy-associated plasma protein A polymorphism with preeclampsia - A pilot study" . . . "Association of pregnancy-associated plasma protein A polymorphism with preeclampsia - A pilot study" . "RIV/00064165:_____/11:9362!RIV12-MZ0-00064165" . . "Muravsk\u00E1, Alexandra" . . . "187337" . . . "Zima, Tom\u00E1\u0161" . . . "The aim of the study was to investigate genetic and biochemical background of PAPP-A (pregnancy-associated plasma protein A) in patients with risk pregnancies. Five PAPP-A gene polymorphisms and PAPP-A maternal serum levels were studied in together 165 women in third trimester pregnancies complicated with threatening preterm labour (n=98), preeclampsia (n=35), intrauterine growth restriction (n=34) and ICP (intrahepatic cholestasis of pregnancy) (n=15). 114 healthy pregnant women served as controls. Preeclamptic patients had significantly higher frequency of TT genotype of Cys327Cys polymorphism compared to controls (p<0.01). Patients with ICP had increased serum levels of PAPP-A compared to controls and correlation analysis showed significant relationship between PAPP-A and CRP (C-reactive protein) in the patients with intrauterine growth restriction (r=0.49, p= 0.007).Our study indicates the association of TT genotype of Cys327Cys polymorphism of the PAPP-A gene with preeclampsia. However, further study with larger groups of preeclamptic patients is needed to confirm our results."@en . . "CA - Kanada" . "Association of pregnancy-associated plasma protein A polymorphism with preeclampsia - A pilot study"@en . "S, Z(MZ0VFN2005)" . . . "Germanov\u00E1, Anna" . "[BFAB14EA2129]" . . . . "000297570300004" . "The aim of the study was to investigate genetic and biochemical background of PAPP-A (pregnancy-associated plasma protein A) in patients with risk pregnancies. Five PAPP-A gene polymorphisms and PAPP-A maternal serum levels were studied in together 165 women in third trimester pregnancies complicated with threatening preterm labour (n=98), preeclampsia (n=35), intrauterine growth restriction (n=34) and ICP (intrahepatic cholestasis of pregnancy) (n=15). 114 healthy pregnant women served as controls. Preeclamptic patients had significantly higher frequency of TT genotype of Cys327Cys polymorphism compared to controls (p<0.01). Patients with ICP had increased serum levels of PAPP-A compared to controls and correlation analysis showed significant relationship between PAPP-A and CRP (C-reactive protein) in the patients with intrauterine growth restriction (r=0.49, p= 0.007).Our study indicates the association of TT genotype of Cys327Cys polymorphism of the PAPP-A gene with preeclampsia. However, further study with larger groups of preeclamptic patients is needed to confirm our results." . "http://dx.doi.org/10.1016/j.clinbiochem.2011.09.015" . . "\u0160varcov\u00E1, Jana" . . . "Intrahepatic cholestasis of pregnancy; PAPP-A; Preeclampsia; Pregnancy-associated plasma protein A; Single nucleotide polymorphism; Gene; Intrauterine growth restriction; Preterm labor"@en . "Clinical Biochemistry" . "Kalousov\u00E1, Marta" . . "0009-9120" . . "H\u00E1jek, Zden\u011Bk" . "7"^^ . . . "J\u00E1chymov\u00E1, Marie" . "Association of pregnancy-associated plasma protein A polymorphism with preeclampsia - A pilot study"@en . "17-18" .