. "Jsou uvedeny n\u011Bkter\u00E9 poznatky o \u00FAloze a funkci serotoninov\u00FDch receptor\u016F a pot\u00E9 jsou shrnuty poznatky o mechanismech \u00FA\u010Dink\u016F antidepresiv ovliv\u0148uj\u00EDc\u00EDch prim\u00E1rn\u011B serotonergn\u00ED syst\u00E9m, p\u0159edev\u0161\u00EDm antidepresiv za\u0159azovan\u00FDch do skupiny selektivn\u00EDch inhibitor\u016F zp\u011Btn\u00E9ho vychyt\u00E1v\u00E1n\u00ED serotoninu (SSRI) a inhibitor\u016F zp\u011Btn\u00E9ho vychyt\u00E1v\u00E1n\u00ED serotoninu i noradrenalinu (SNRI). Na z\u00E1klad\u011B t\u011Bchto poznatk\u016F lze na receptorov\u00E9 a postreceptorov\u00E9 \u00FArovni vysv\u011Btlit \u00FA\u010Dinky serotoninov\u00FDch antagonist\u016F a inhibitor\u016F zp\u011Btn\u00E9ho vychyt\u00E1v\u00E1n\u00ED (SARI), co\u017E je uk\u00E1z\u00E1no na p\u0159\u00EDkladu multifunk\u010Dn\u00EDho l\u00E9ku trazodonu. Zpo\u017Ed\u011Bn\u00FD n\u00E1stup terapeutick\u00FDch \u00FA\u010Dink\u016F antidepresiv je z\u0159ejm\u011B d\u00E1n mechanismem jejich p\u016Fsoben\u00ED, nikoli samotn\u00FDm onemocn\u011Bn\u00EDm. Objev nov\u00FDch rychleji p\u016Fsob\u00EDc\u00EDch antidepresiv proto vy\u017Eaduje dal\u0161\u00ED v\u00FDzkum biologick\u00FDch charakteristik deprese a jej\u00ED l\u00E9\u010Dby." . "CZ - \u010Cesk\u00E1 republika" . "Serotonergn\u00ED \u00FA\u010Dinky antidepresiv" . . "Serotonergn\u00ED \u00FA\u010Dinky antidepresiv"@cs . "2" . . "Serotonergic effects of antidepressants"@en . "Selected findings are noticed about the role and function of serotonin receptors followed by disclosure of mechanisms of action of antidepressants affecting primary serotonergic system; specifically, by antidepressants classified as selective serotonin reuptake inhibitors (SSRIs) or serotonin\u2013norepinephrine reuptake inhibitors (SNRIs). Following of these findings, mechanisms of receptor and postreceptor action of serotonin antagonist and reuptake inhibitors (SARIs) can be clarified, which is demonstrated on example of multifunctional drug trazodone. The delay in onset of therapeutic efficiency of antidepressants is a function of the drugs, rather than the disease. Research into the biological characteristics of depression and its treatment may yield faster-acting antidepressants."@en . . . "Fi\u0161ar, Zden\u011Bk" . . "Raboch, Ji\u0159\u00ED" . "2"^^ . "http://www.cspsychiatr.cz/dwnld/CSP_2011_2_115_120.pdf" . . "1212-0383" . "Serotonergic effects of antidepressants"@en . . . "Jsou uvedeny n\u011Bkter\u00E9 poznatky o \u00FAloze a funkci serotoninov\u00FDch receptor\u016F a pot\u00E9 jsou shrnuty poznatky o mechanismech \u00FA\u010Dink\u016F antidepresiv ovliv\u0148uj\u00EDc\u00EDch prim\u00E1rn\u011B serotonergn\u00ED syst\u00E9m, p\u0159edev\u0161\u00EDm antidepresiv za\u0159azovan\u00FDch do skupiny selektivn\u00EDch inhibitor\u016F zp\u011Btn\u00E9ho vychyt\u00E1v\u00E1n\u00ED serotoninu (SSRI) a inhibitor\u016F zp\u011Btn\u00E9ho vychyt\u00E1v\u00E1n\u00ED serotoninu i noradrenalinu (SNRI). Na z\u00E1klad\u011B t\u011Bchto poznatk\u016F lze na receptorov\u00E9 a postreceptorov\u00E9 \u00FArovni vysv\u011Btlit \u00FA\u010Dinky serotoninov\u00FDch antagonist\u016F a inhibitor\u016F zp\u011Btn\u00E9ho vychyt\u00E1v\u00E1n\u00ED (SARI), co\u017E je uk\u00E1z\u00E1no na p\u0159\u00EDkladu multifunk\u010Dn\u00EDho l\u00E9ku trazodonu. Zpo\u017Ed\u011Bn\u00FD n\u00E1stup terapeutick\u00FDch \u00FA\u010Dink\u016F antidepresiv je z\u0159ejm\u011B d\u00E1n mechanismem jejich p\u016Fsoben\u00ED, nikoli samotn\u00FDm onemocn\u011Bn\u00EDm. Objev nov\u00FDch rychleji p\u016Fsob\u00EDc\u00EDch antidepresiv proto vy\u017Eaduje dal\u0161\u00ED v\u00FDzkum biologick\u00FDch charakteristik deprese a jej\u00ED l\u00E9\u010Dby."@cs . "1"^^ . "\u010Cesk\u00E1 a slovensk\u00E1 psychiatrie" . "RIV/00064165:_____/11:9292!RIV12-MZ0-00064165" . . . "Serotonergn\u00ED \u00FA\u010Dinky antidepresiv" . "I, Z(MSM0021620849)" . "antidepressants; serotonin transporter; serotonin receptor; trazodone"@en . "[45519F838967]" . . . "Serotonergn\u00ED \u00FA\u010Dinky antidepresiv"@cs . . "107" . . . "228963" . "RIV/00064165:_____/11:9292" . . . "6"^^ .