"Prim\u00E1rn\u00ED hyperaldosteronismus je charakterizov\u00E1n autonomn\u00ED nadprodukc\u00ED aldosteronu. Vyskytuje se nej\u010Dast\u011Bji ve dvou form\u00E1ch \u2013aldosteron produkuj\u00EDc\u00ED adenom a bilater\u00E1ln\u00ED hyperplazie nadledvin (idiopatick\u00FD hyperaldosteronismus). Podle sou\u010Dasn\u00FDch poznatk\u016F je nej\u010Dast\u011Bj\u0161\u00ED formou sekund\u00E1rn\u00ED hypertenze. Nejv\u011Bt\u0161\u00ED v\u00FDskyt prim\u00E1rn\u00EDho hyperaldosteronismu lze o\u010Dek\u00E1vat u t\u011B\u017Ek\u00E9 rezistentn\u00ED arteri\u00E1ln\u00ED hypertenze s, ale i bez p\u0159\u00EDtomn\u00E9 hypokal\u00E9mie. V\u00FDznamn\u00FDm d\u016Fvodem, pro\u010D se sna\u017E\u00EDme odhalit tuto formu sekund\u00E1rn\u00ED hypertenze je i nezanedbateln\u011B v\u011Bt\u0161\u00ED riziko kardiovaskul\u00E1rn\u00EDch komplikac\u00ED dan\u00FDch nejenom t\u00ED\u017E\u00ED hypertenze a hypokal\u00E9mi\u00ED, ale i p\u0159\u00EDm\u00FDm po\u0161kozen\u00EDm c\u00E9vn\u00ED st\u011Bny nadbytkem aldosteronu. Z\u00E1kladn\u00EDm screeningov\u00FDm testem v diagnostice je stanoven\u00ED pom\u011Bru aldosteron/renin, v p\u0159\u00EDpad\u011B pozitivity n\u00E1sleduje potvrzen\u00ED diagn\u00F3zy pomoc\u00ED supresn\u00EDho testu. Diferenci\u00E1ln\u00ED diagnostika je pak komplikovan\u011Bj\u0161\u00ED a prob\u00EDh\u00E1 ve specializovan\u00FDch centrech." . . . . "1"^^ . "Prim\u00E1rn\u00ED hyperaldosteronismus je charakterizov\u00E1n autonomn\u00ED nadprodukc\u00ED aldosteronu. Vyskytuje se nej\u010Dast\u011Bji ve dvou form\u00E1ch \u2013aldosteron produkuj\u00EDc\u00ED adenom a bilater\u00E1ln\u00ED hyperplazie nadledvin (idiopatick\u00FD hyperaldosteronismus). Podle sou\u010Dasn\u00FDch poznatk\u016F je nej\u010Dast\u011Bj\u0161\u00ED formou sekund\u00E1rn\u00ED hypertenze. Nejv\u011Bt\u0161\u00ED v\u00FDskyt prim\u00E1rn\u00EDho hyperaldosteronismu lze o\u010Dek\u00E1vat u t\u011B\u017Ek\u00E9 rezistentn\u00ED arteri\u00E1ln\u00ED hypertenze s, ale i bez p\u0159\u00EDtomn\u00E9 hypokal\u00E9mie. V\u00FDznamn\u00FDm d\u016Fvodem, pro\u010D se sna\u017E\u00EDme odhalit tuto formu sekund\u00E1rn\u00ED hypertenze je i nezanedbateln\u011B v\u011Bt\u0161\u00ED riziko kardiovaskul\u00E1rn\u00EDch komplikac\u00ED dan\u00FDch nejenom t\u00ED\u017E\u00ED hypertenze a hypokal\u00E9mi\u00ED, ale i p\u0159\u00EDm\u00FDm po\u0161kozen\u00EDm c\u00E9vn\u00ED st\u011Bny nadbytkem aldosteronu. Z\u00E1kladn\u00EDm screeningov\u00FDm testem v diagnostice je stanoven\u00ED pom\u011Bru aldosteron/renin, v p\u0159\u00EDpad\u011B pozitivity n\u00E1sleduje potvrzen\u00ED diagn\u00F3zy pomoc\u00ED supresn\u00EDho testu. Diferenci\u00E1ln\u00ED diagnostika je pak komplikovan\u011Bj\u0161\u00ED a prob\u00EDh\u00E1 ve specializovan\u00FDch centrech."@cs . "Primary aldosteronism \u2013 the most frequent form of secondary hypertension"@en . "Primary aldosteronism \u2013 the most frequent form of secondary hypertension"@en . "[B510E4E85440]" . . "RIV/00064165:_____/10:6766!RIV11-MZ0-00064165" . "8" . . "Postgradu\u00E1ln\u00ED medic\u00EDna. Prim\u00E1rn\u00ED hyperaldosteronismus \u2013 nej\u010Dast\u011Bj\u0161\u00ED p\u0159\u00ED\u010Dina sekund\u00E1rn\u00ED hypertenze" . "8"^^ . "V" . "Postgradu\u00E1ln\u00ED medic\u00EDna. Prim\u00E1rn\u00ED hyperaldosteronismus \u2013 nej\u010Dast\u011Bj\u0161\u00ED p\u0159\u00ED\u010Dina sekund\u00E1rn\u00ED hypertenze" . "1212-4184" . . "12" . "1"^^ . . "Primary aldosteronism is defined by autonomous aldosterone overproduction. Aldosterone producing adenoma and bilateral adrenal hyperplasia (idiopathic aldosteronism) are the most frequent subtypes of primary aldosteronism. Primary aldosteronism is according to the current knowledge the most frequent form of secondary hypertension. The highest prevalence of primary aldosteronism can be awaited in patients with moderate to severe hypertension with, but also without hypokalemia. Significantly increased cardiovascular risk in primary aldosteronism is caused not only by hypertension and hypokalemia, but also by direct effect of excess aldosterone, as the most important reasons why to screen for primary aldosteronism. Aldosterone/plasma renin activity ratio is the first screening test, followed by a confirmation test. The differential diagnosis of the different subtypes of primary aldosteronism is more complicated and therefore performed in hypertension centers."@en . . "280323" . "RIV/00064165:_____/10:6766" . "\u0160trauch, Branislav" . "Postgradu\u00E1ln\u00ED medic\u00EDna" . "Postgradu\u00E1ln\u00ED medic\u00EDna. Prim\u00E1rn\u00ED hyperaldosteronismus \u2013 nej\u010Dast\u011Bj\u0161\u00ED p\u0159\u00ED\u010Dina sekund\u00E1rn\u00ED hypertenze"@cs . . "Aldosteronism; secondary endocrine hypertension; aldosterone"@en . "CZ - \u010Cesk\u00E1 republika" . . . . . . "Postgradu\u00E1ln\u00ED medic\u00EDna. Prim\u00E1rn\u00ED hyperaldosteronismus \u2013 nej\u010Dast\u011Bj\u0161\u00ED p\u0159\u00ED\u010Dina sekund\u00E1rn\u00ED hypertenze"@cs .