. . "The beginning of the dynamic development of nucleic acids sequencing dates back to 1977, when the method for sequencing using the chain-terminating dideoxynucleotides was described. Another important time point was year 2007 when Roche company introduced a new device that uses pyrosequencing. Even the least efficient devices are able to generate 100, 000 x 400 bp overnight, i.e. 40 million base pairs. Clonal sequencing can be used for whole genomes sequencing, characterization of microbial populations by sequencing variable region of genes for ribosomal RNA, but also for monitoring gene expression, e.g., when studying the immune response to infection."@en . "1"^^ . . . "Rychl\u00EDk, Ivan" . . . "Po\u010D\u00E1tek dynamick\u00E9ho rozvoje sekvenov\u00E1n\u00ED nukleov\u00FDch kyselin lze datovat do roku 1977, kdy byl pops\u00E1n zp\u016Fsob sekvenov\u00E1n\u00ED s vyu\u017Eit\u00EDm dideoxytermin\u00E1tor\u016F. Dal\u0161\u00EDm miln\u00EDkem byl rok 2007, kdy spole\u010Dnost Roche zavedla na trh nov\u00FD p\u0159\u00EDstroj, kter\u00FD vyu\u017E\u00EDv\u00E1 principu pyrosekvenov\u00E1n\u00ED. I ty nejm\u00E9n\u011B v\u00FDkonn\u00E9 p\u0159\u00EDstroje dok\u00E1\u017E\u00ED p\u0159es noc vygenerovat 100 000 x 400 bp, tedy 40 000 000 p\u00E1ru baz\u00ED. Klon\u00E1ln\u00ED sekvenov\u00E1n\u00ED lze vyu\u017E\u00EDt p\u0159i sekvenov\u00E1n\u00ED cel\u00FDch genom\u016F, charakterizaci mikrobi\u00E1ln\u00EDch populac\u00ED sekvenov\u00E1n\u00EDm variabiln\u00EDch oblast\u00ED genu pro ribozom\u00E1ln\u00ED RNA, ale i ke sledov\u00E1n\u00ED genov\u00E9 exprese, nap\u0159. p\u0159i studiu imunitn\u00ED reakce na infekci." . "92314" . "Po\u010D\u00E1tek dynamick\u00E9ho rozvoje sekvenov\u00E1n\u00ED nukleov\u00FDch kyselin lze datovat do roku 1977, kdy byl pops\u00E1n zp\u016Fsob sekvenov\u00E1n\u00ED s vyu\u017Eit\u00EDm dideoxytermin\u00E1tor\u016F. Dal\u0161\u00EDm miln\u00EDkem byl rok 2007, kdy spole\u010Dnost Roche zavedla na trh nov\u00FD p\u0159\u00EDstroj, kter\u00FD vyu\u017E\u00EDv\u00E1 principu pyrosekvenov\u00E1n\u00ED. I ty nejm\u00E9n\u011B v\u00FDkonn\u00E9 p\u0159\u00EDstroje dok\u00E1\u017E\u00ED p\u0159es noc vygenerovat 100 000 x 400 bp, tedy 40 000 000 p\u00E1ru baz\u00ED. Klon\u00E1ln\u00ED sekvenov\u00E1n\u00ED lze vyu\u017E\u00EDt p\u0159i sekvenov\u00E1n\u00ED cel\u00FDch genom\u016F, charakterizaci mikrobi\u00E1ln\u00EDch populac\u00ED sekvenov\u00E1n\u00EDm variabiln\u00EDch oblast\u00ED genu pro ribozom\u00E1ln\u00ED RNA, ale i ke sledov\u00E1n\u00ED genov\u00E9 exprese, nap\u0159. p\u0159i studiu imunitn\u00ED reakce na infekci."@cs . "RIV/00027162:_____/13:#0001067" . "Nov\u00E9 trendy v sekvenov\u00E1n\u00ED nukleov\u00FDch kyselin a mo\u017Enosti jejich vyu\u017Eit\u00ED" . "New trends in nucleic acid sequencing and applications"@en . "Nov\u00E9 trendy v sekvenov\u00E1n\u00ED nukleov\u00FDch kyselin a mo\u017Enosti jejich vyu\u017Eit\u00ED" . . "RIV/00027162:_____/13:#0001067!RIV14-MZE-00027162" . "Nov\u00E9 trendy v sekvenov\u00E1n\u00ED nukleov\u00FDch kyselin a mo\u017Enosti jejich vyu\u017Eit\u00ED"@cs . "New trends in nucleic acid sequencing and applications"@en . . . "sequencing; nucleic acid"@en . "P(ED0006/01/01), Z(MZE0002716202)" . . . . . . . "1"^^ . "Nov\u00E9 trendy v sekvenov\u00E1n\u00ED nukleov\u00FDch kyselin a mo\u017Enosti jejich vyu\u017Eit\u00ED"@cs . . "[AB908383BB26]" . .