. "Bioprospekt" . "2"^^ . . "22" . "Nanobodies: new immureagents for research, diagnostics and therapy"@en . "Nanoprotil\u00E1tky: Nov\u00E9 imunoreagenty pro v\u00FDzkum, diagnostiku a terapii" . "Nanoprotil\u00E1tky jsou rekombinantn\u00ED fragmenty odvozen\u00E9 z protil\u00E1tek tvo\u0159en\u00FDch t\u011B\u017Ek\u00FDmi \u0159et\u011Bzci, kter\u00E9 se vyskytuj\u00ED v krevn\u00EDm s\u00E9ru a tk\u00E1n\u00EDch savc\u016F \u010Deledi Camelidae. Nanoprotil\u00E1tky se li\u0161\u00ED od konven\u010Dn\u00EDch protil\u00E1tek i jin\u00FDch rekombinantn\u00EDch fragment\u016F \u0159adou jedine\u010Dn\u00FDch vlastnost\u00ED, jako je mal\u00E1 velikost molekuly, dobr\u00E1 rozpustnost ve vodn\u00E9m prost\u0159ed\u00ED a konforma\u010Dn\u00ED stabilita p\u0159i vysok\u00FDch teplot\u00E1ch i p\u0159i n\u00EDzk\u00FDch hodnot\u00E1ch pH. Vypukl\u00FD (konvexn\u00ED) tvar vazebn\u00E9ho m\u00EDsta umo\u017E\u0148uje nanoprotil\u00E1tk\u00E1m rozpozn\u00E1vat epitopy, kter\u00E9 jsou lokalizov\u00E1ny v dutin\u00E1ch protein\u016F nebo z\u00E1hybech virov\u00FDch obal\u016F a bun\u011B\u010Dn\u00FDch membr\u00E1n. D\u00EDky uveden\u00FDm vlastnostem mohou b\u00FDt nanoprotil\u00E1tky v budoucnosti vyu\u017E\u00EDv\u00E1ny jako \u00FA\u010Dinn\u00E1 terapeutika i jako reagenty v imunoanalytick\u00FDch a diagnostick\u00FDch metod\u00E1ch." . "2"^^ . . "Nanoprotil\u00E1tky: Nov\u00E9 imunoreagenty pro v\u00FDzkum, diagnostiku a terapii" . "RIV/00027162:_____/12:#0000911" . . . . "nanobody; recombinant fragment; antigen; binding site; phage library"@en . "CZ - \u010Cesk\u00E1 republika" . . . "Nanoprotil\u00E1tky jsou rekombinantn\u00ED fragmenty odvozen\u00E9 z protil\u00E1tek tvo\u0159en\u00FDch t\u011B\u017Ek\u00FDmi \u0159et\u011Bzci, kter\u00E9 se vyskytuj\u00ED v krevn\u00EDm s\u00E9ru a tk\u00E1n\u00EDch savc\u016F \u010Deledi Camelidae. Nanoprotil\u00E1tky se li\u0161\u00ED od konven\u010Dn\u00EDch protil\u00E1tek i jin\u00FDch rekombinantn\u00EDch fragment\u016F \u0159adou jedine\u010Dn\u00FDch vlastnost\u00ED, jako je mal\u00E1 velikost molekuly, dobr\u00E1 rozpustnost ve vodn\u00E9m prost\u0159ed\u00ED a konforma\u010Dn\u00ED stabilita p\u0159i vysok\u00FDch teplot\u00E1ch i p\u0159i n\u00EDzk\u00FDch hodnot\u00E1ch pH. Vypukl\u00FD (konvexn\u00ED) tvar vazebn\u00E9ho m\u00EDsta umo\u017E\u0148uje nanoprotil\u00E1tk\u00E1m rozpozn\u00E1vat epitopy, kter\u00E9 jsou lokalizov\u00E1ny v dutin\u00E1ch protein\u016F nebo z\u00E1hybech virov\u00FDch obal\u016F a bun\u011B\u010Dn\u00FDch membr\u00E1n. D\u00EDky uveden\u00FDm vlastnostem mohou b\u00FDt nanoprotil\u00E1tky v budoucnosti vyu\u017E\u00EDv\u00E1ny jako \u00FA\u010Dinn\u00E1 terapeutika i jako reagenty v imunoanalytick\u00FDch a diagnostick\u00FDch metod\u00E1ch."@cs . . "152958" . "Nanoprotil\u00E1tky: Nov\u00E9 imunoreagenty pro v\u00FDzkum, diagnostiku a terapii"@cs . . "Eyer, Lud\u011Bk" . . . . "Fr\u00E1nek, Milan" . "6"^^ . . . "RIV/00027162:_____/12:#0000911!RIV13-MZE-00027162" . "Nanobodies are recombinant fragments derived from heavy-chain antibodies which occur in blood serum and tissues of camelids. Nanobodies differ from conventional antibodies and other recombinant fragments in numerous unique properties, such as a small molecular size, good water solubility and conformational stability at high temperatures, as well as at low pH values. The convex shape of binding sites of nanobodies enables them to recognize epitopes which are buried in protein cavities or clefts of viral envelopes and cell membranes. Due to their properties, nanobodies could be in the future applied as effective therapeutics and also as reagents in immunoanalytical and diagnostic methods."@en . "Nanoprotil\u00E1tky: Nov\u00E9 imunoreagenty pro v\u00FDzkum, diagnostiku a terapii"@cs . . "2" . . "[8060830C9076]" . . "1210-1737" . . . "P(ED0006/01/01), Z(MZE0002716202)" . "Nanobodies: new immureagents for research, diagnostics and therapy"@en . .