. "The objective of this study was to investigate the effects of postnatal exposure to benz(a)anthracene (B(a)A) and benzo(k)fluoranthene (B(k)F) on the development of the rat uterus. Neonates were injected subcutaneously on each postnatal day 1-14 with B(a)A (0.1, 1.0 or 10.0 mg/kg), B(k)F (0.1, 1.0 or 5.0 mg/kg), ethynylestradiol (EE; 1.0 ug/kg) or a vehicle. The rats were killed on day 23. All doses of B(a)A and B(k)F induced a significant reduction of the uterine weight, a reduction of the estrogen receptor alpha expression in the luminal epithelium, glandular epithelium and stromal cells. Moreover, the uterotrophic response to EE (three-day administration of 1.0 ug/kg on postnatal days 20-22) in rats exposed to B(a)A, B(k)F and EE was significantly lower than in controls. The study showed that postnatal exposure to B(a)A or B(k)F results in morphological and functional disorders of the immature rat uterus." . "Morphological and functional disorders of the immature rat uterus after postnatal exposure to benz(a)anthracene and benzo(k)fluoranthene" . . . . "Morphological and functional disorders of the immature rat uterus after postnatal exposure to benz(a)anthracene and benzo(k)fluoranthene"@en . . . "The objective of this study was to investigate the effects of postnatal exposure to benz(a)anthracene (B(a)A) and benzo(k)fluoranthene (B(k)F) on the development of the rat uterus. Neonates were injected subcutaneously on each postnatal day 1-14 with B(a)A (0.1, 1.0 or 10.0 mg/kg), B(k)F (0.1, 1.0 or 5.0 mg/kg), ethynylestradiol (EE; 1.0 ug/kg) or a vehicle. The rats were killed on day 23. All doses of B(a)A and B(k)F induced a significant reduction of the uterine weight, a reduction of the estrogen receptor alpha expression in the luminal epithelium, glandular epithelium and stromal cells. Moreover, the uterotrophic response to EE (three-day administration of 1.0 ug/kg on postnatal days 20-22) in rats exposed to B(a)A, B(k)F and EE was significantly lower than in controls. The study showed that postnatal exposure to B(a)A or B(k)F results in morphological and functional disorders of the immature rat uterus."@en . "Morphological and functional disorders of the immature rat uterus after postnatal exposure to benz(a)anthracene and benzo(k)fluoranthene"@en . "Environmental Toxicology and Pharmacology" . . . . . . "000264387200014" . . "Matia\u0161ovic, J\u00E1n" . "6"^^ . . "RIV/00027162:_____/09:#0000486" . . . "[3973EFF02004]" . . "4"^^ . "Morphological and functional disorders of the immature rat uterus after postnatal exposure to benz(a)anthracene and benzo(k)fluoranthene" . "3" . "4"^^ . "NL - Nizozemsko" . . "27" . . "1382-6689" . "Ma\u0161kov\u00E1, Jarmila" . "P(GA525/05/2695), Z(MZE0002716201)" . . . "Kummer, Vladim\u00EDr" . "Faldyna, Martin" . "polcyclic aromatic hydrocarbons; estrogen receptor; immunohistochemistry; rat uterotrophic bioassay"@en . . "327471" . "RIV/00027162:_____/09:#0000486!RIV10-MZE-00027162" .