. "216"^^ . . "Polychlorinated biphenyls (PCBs) are thought to cause numerous adverse health effects, but their impact on estrogen signaling is still not fully understood. In the present study, we used the ER-CALUX bioassay to determine estrogenic/antiestrogenic activities of the prevalent PCB congeners and PCB mixtures isolated from human male serum. The samples were collected from residents of an area with an extensive environmental contamination from a former PCB production site as well as from a neighboring background region in eastern Slovakia. We found that the lowerchlorinated PCBs were estrogenic, whereas the prevalent higher-chlorinated PCB congeners 138, 153, 170, 180, 187, 194, 199, and 203, as well as major PCB metabolites, behaved as antiestrogens. 17 beta-Estradiol (E2) was responsible for a major part of estrogenic activity identified in total serum extracts." . . "University of Illinois" . "Ne\u010Da, Ji\u0159\u00ED" . "polychlorinated biphenyls; dioxin-like activity"@en . "Je zn\u00E1mo, \u017Ee polychlorovan\u00E9 bifenyly (PCB) p\u016Fsob\u00ED \u0159adou nep\u0159\u00EDzniv\u00FDch efekt\u016F na lidsk\u00E9 zdrav\u00ED, ale jejich vliv na estrogenov\u00E9 sign\u00E1lov\u00E1n\u00ED nen\u00ED je\u0161t\u011B pln\u011B objasn\u011Bn. V t\u00E9to studii byly stanoveny estrogenn\u00ED/antiestrogenn\u00ED vlastnosti b\u011B\u017En\u011B roz\u0161\u00ED\u0159en\u00FDch PCB a sm\u011Bs\u00ED PCB, kter\u00E9 byly izolov\u00E1ny ze s\u00E9ra mu\u017E\u016F z vysoce kontaminovan\u00FDch oblast\u00ED v\u00FDchodn\u00EDho Slovenska. Bylo zji\u0161t\u011Bno, \u017Ee n\u00ED\u017Eechlorovan\u00E9 PCB byly estrogenn\u00ED, zat\u00EDmco v\u00FD\u0161echlorovan\u00E9 PCB 138, 153, 170, 180, 187, 194, 199, 203 a jejich metabolity byly antiestrogenn\u00ED. Vysok\u00E1 hladina PCB ve vzorc\u00EDch mu\u017Esk\u00FDch s\u00E9r souvisela s poklesem estrogenov\u00E9 aktivity a n\u00E1r\u016Fstem dioxinov\u00E9 aktivity."@cs . "R" . "Vondr\u00E1\u010Dek, Jan" . "Pl\u00ED\u0161kov\u00E1, Martina" . "Van den Berg, M." . "Sanderson, T." . . "PCBs Human and Environmental Disposition and Toxicology" . "978-0-252-03254-7" . "Estrogenn\u00ED, antiestrogenn\u00ED a dioxinov\u00E9 aktivity ve vzorc\u00EDch lidsk\u00FDch mu\u017Esk\u00FDch s\u00E9r z v\u00FDchodn\u00EDho Slovenska"@cs . "Petr\u00EDk, J." . . "Trnovec, T." . "Ko\u010Dan, A." . "Estrogenic, Antiestroegnic, and Dioxin-Like Activities in Human Male Serum Samples from Eastern Slovakia"@en . . . "[0C1EF8DDF57E]" . "10"^^ . "Estrogenic, Antiestroegnic, and Dioxin-Like Activities in Human Male Serum Samples from Eastern Slovakia" . "366570" . . "Polychlorinated biphenyls (PCBs) are thought to cause numerous adverse health effects, but their impact on estrogen signaling is still not fully understood. In the present study, we used the ER-CALUX bioassay to determine estrogenic/antiestrogenic activities of the prevalent PCB congeners and PCB mixtures isolated from human male serum. The samples were collected from residents of an area with an extensive environmental contamination from a former PCB production site as well as from a neighboring background region in eastern Slovakia. We found that the lowerchlorinated PCBs were estrogenic, whereas the prevalent higher-chlorinated PCB congeners 138, 153, 170, 180, 187, 194, 199, and 203, as well as major PCB metabolites, behaved as antiestrogens. 17 beta-Estradiol (E2) was responsible for a major part of estrogenic activity identified in total serum extracts."@en . . "12"^^ . "4"^^ . . "Estrogenic, Antiestroegnic, and Dioxin-Like Activities in Human Male Serum Samples from Eastern Slovakia" . . . . . "Carton, R." . "Estrogenn\u00ED, antiestrogenn\u00ED a dioxinov\u00E9 aktivity ve vzorc\u00EDch lidsk\u00FDch mu\u017Esk\u00FDch s\u00E9r z v\u00FDchodn\u00EDho Slovenska"@cs . "Machala, Miroslav" . . . "Estrogenic, Antiestroegnic, and Dioxin-Like Activities in Human Male Serum Samples from Eastern Slovakia"@en . "Illinois, USA" . "RIV/00027162:_____/08:#0000471" . "RIV/00027162:_____/08:#0000471!RIV09-MZE-00027162" .