"polycyclic aromatic hydrocarbons; rat immature uterotrophic assay; estrogen receptor; cytochrome P450; estradiol metabolism; p53"@en . . . . . "Ma\u0161kov\u00E1, Jarmila" . "RIV/00027162:_____/08:#0000359" . . "Estrogenn\u00ED aktivita polycyklick\u00FDch aromatick\u00FDch uhlovod\u00EDk\u016F v d\u011Bloze immaturn\u00EDch Wistar potkan\u016F"@cs . "Pol\u00E1\u0161kov\u00E1, Pavl\u00EDna" . . . . "366569" . "10"^^ . "Estrogenic activity of environmental polycyclic aromatic hydrocarbons in uterus of immature Wistar rats" . "180" . . "Machala, Miroslav" . . . "0378-4274" . "000259461000008" . "Zral\u00FD, Zden\u011Bk" . . . . "7"^^ . . . . . "7"^^ . . "Kummer, Vladim\u00EDr" . "The study: estrogenic/antiestrogenic effects of benzo(a)pyrene (BaP), benz(a)anthracene (BaA), fluoranthene (Fla) and benzo(k)fluoranthene (BkF), using the immature rat uterotrophic assay. The results suggest that BaA, BaP and Fla behaved as estrogen-like compounds, when applied at 10 mg/kg/day, as documented by a significant increase of uterine weight and hypertrophy of luminal epithelium. These effects were likely to be mediated by ER alpha, which was downregulated following the treatment with PAHs, as they were inhibited by treatment with ER antagonist ICI 182,780. BaA induced a significant estrogenic effect already at the dose of 0.1 mg/kg/day. The proposed antiestrogenicity of the potent AhR agonist BkF was not confirmed. The PAHs under study did not induce marked genotoxic damage in uterine tissues, as documented by the lack of Ser-15-phoshorylated p53 protein staining. With the exception of Fla, all three remaining PAHs increased CYP1-dependent monooxygenation activities in liver." . "Toxicology Letters" . "RIV/00027162:_____/08:#0000359!RIV09-MZE-00027162" . "Estrogenic activity of environmental polycyclic aromatic hydrocarbons in uterus of immature Wistar rats" . "Estrogenic activity of environmental polycyclic aromatic hydrocarbons in uterus of immature Wistar rats"@en . . "IE - Irsko" . "C\u00EDl studie: pro\u0161et\u0159it potenci\u00E1ln\u00ED estrogenn\u00ED/antiestrogenn\u00ED \u00FA\u010Dinky benzo(a)pyrenu (BaP), benz(a)antracenu (BaA), fluorantenu (Fla) and benzo(k)fluorantenu (BkF) pou\u017Eit\u00EDm uterotrofn\u00ED bioassay u immaturn\u00EDch potkan\u016F. V\u00FDsledky nasv\u011Bd\u010Duj\u00ED tomu, \u017Ee p\u0159i aplikaci 10 mg/kg/den vykazovaly BaA, BaP a Fla slabou estrogenn\u00ED aktivitu, co\u017E potvrdil signifikantn\u00ED n\u00E1r\u016Fst v\u00E1hy d\u011Blohy a hypertrofie lumin\u00E1ln\u00EDho epitelu. Tento efekt byl zprost\u0159edkov\u00E1n via ER alfa a byl blokov\u00E1n simult\u00E1nn\u00ED aplikac\u00ED ER antagonisty ICI 182,780. Aplikace t\u011Bchto PAHs vedla ke sn\u00ED\u017Een\u00ED exprese ER v d\u011Bloze. BaA indukoval pr\u016Fkazn\u00FD estrogenn\u00ED \u00FA\u010Dinek ji\u017E od d\u00E1vky 0.1 mg/kg. Antiestrogenita BkF, pat\u0159\u00EDc\u00EDho mezi AhR agonisty nebyla potvrzena. Studovan\u00E9 PAHs nevyvolaly v d\u011Blo\u017En\u00ED tk\u00E1ni z\u0159ejm\u00E9 genotoxick\u00E9 po\u0161kozen\u00ED, o \u010Dem\u017E sv\u011Bd\u010Dila slab\u00E1 \u00FArove\u0148 barven\u00ED Ser-15-fosforylace protein p53. S v\u00FDjimkou Fla v\u0161echny zb\u00FDvaj\u00EDc\u00ED PAHs zvy\u0161ovaly CYP1-dependentn\u00ED aktivitu monooxygenace v j\u00E1trech."@cs . . . . . "Vondr\u00E1\u010Dek, Jan" . "3" . "[EF4B0F551410]" . "The study: estrogenic/antiestrogenic effects of benzo(a)pyrene (BaP), benz(a)anthracene (BaA), fluoranthene (Fla) and benzo(k)fluoranthene (BkF), using the immature rat uterotrophic assay. The results suggest that BaA, BaP and Fla behaved as estrogen-like compounds, when applied at 10 mg/kg/day, as documented by a significant increase of uterine weight and hypertrophy of luminal epithelium. These effects were likely to be mediated by ER alpha, which was downregulated following the treatment with PAHs, as they were inhibited by treatment with ER antagonist ICI 182,780. BaA induced a significant estrogenic effect already at the dose of 0.1 mg/kg/day. The proposed antiestrogenicity of the potent AhR agonist BkF was not confirmed. The PAHs under study did not induce marked genotoxic damage in uterine tissues, as documented by the lack of Ser-15-phoshorylated p53 protein staining. With the exception of Fla, all three remaining PAHs increased CYP1-dependent monooxygenation activities in liver."@en . "Estrogenn\u00ED aktivita polycyklick\u00FDch aromatick\u00FDch uhlovod\u00EDk\u016F v d\u011Bloze immaturn\u00EDch Wistar potkan\u016F"@cs . "Ne\u010Da, Ji\u0159\u00ED" . . . . . "P(GA525/05/2695), Z(AV0Z50040507), Z(AV0Z50040702), Z(MZE0002716201)" . "Estrogenic activity of environmental polycyclic aromatic hydrocarbons in uterus of immature Wistar rats"@en .