"Sperm fluorescence in situ hybridization study of meiotic segregation and an interchromosomal effect in carriers of t(11;18)"@en . "000253746900017" . "Vozdov\u00E1, Milu\u0161e" . . "RIV/00027162:_____/08:#0000350!RIV09-MZE-00027162" . "Human Reproduction" . "23" . . . . "[951E1F0411A1]" . . . . . "RIV/00027162:_____/08:#0000350" . . "3" . "396488" . "Or\u00E1\u010Dov\u00E1, Eva" . . . "Sperm fluorescence in situ hybridization study of meiotic segregation and an interchromosomal effect in carriers of t(11;18)" . "Balanced translocations are associated with infertility, spontaneous abortions and birth defects. We report the analysis, by multicolour fluorescence in situ hybridization (FISH), of meiotic segregation and aneuploidy of chromosomes X, Y, 7, 8 and 21 in sperm from three carriers of two different t(11;18). The prevalence of alternate segregation followed by adjacent 1, adjacent 2, and 3:1 was observed in all three patients. Two carriers of the same translocation differed only in the frequency of adjacent 2 segregation. The carrier of the other translocation showed significantly higher frequency of alternate and less adjacent 1 and 3:1 segregation products. An increased frequency of XY, YY and diploid sperm was detected in the group of translocation carriers compared to controls. This was caused by elevated frequencies of disomy and diploidy in two of our carriers. The incidence of abnormal gametes varies in the individual carriers even if the same chromosomes are included in the translocation." . "Meiotick\u00E1 segregace a interchromosom\u00E1ln\u00ED efekt u nositel\u016F translokace t(11;18) studovan\u00E9 metodou Sperm FISH"@cs . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "8"^^ . "Sperm fluorescence in situ hybridization study of meiotic segregation and an interchromosomal effect in carriers of t(11;18)"@en . . "0268-1161" . . "Balancovan\u00E9 translokace jsou spojeny s infertilitou, spont\u00E1nn\u00EDmi aborty a vrozen\u00FDmi defekty. Referujeme o anal\u00FDze meiotick\u00E9 segregace a aneuploidi\u00ED chromosom\u016F X, Y, 7, 8 a 21 ve spermi\u00EDch 3 nositel\u016F 2 r\u016Fzn\u00FDch t(11;18) mnohobarevnou FISH. Nej\u010Dast\u011Bji byla pozorov\u00E1na alternativn\u00ED segregace a d\u00E1le segregace typu 1, typu 2 a 3:1. Nositel\u00E9 stejn\u00E9 translokace se li\u0161ili ve frekvenci segregace typu 2. Nositel odli\u0161n\u00E9 translokace vykazoval v\u00EDce produkt\u016F alternativn\u00ED segregace a m\u00E9n\u011B typu 1 a 3:1. Ve srovn\u00E1n\u00ED s kontrolami byla pozorov\u00E1na zv\u00FD\u0161en\u00E1 frekvence XY, YY a diploidn\u00EDch spermi\u00ED, co\u017E bylo zp\u016Fsobeno jejich vysokou frekvenc\u00ED u dvou z nositel\u016F translokac\u00ED. Incidence abnorm\u00E1ln\u00EDch gamet se li\u0161\u00ED u jednotliv\u00FDch nositel\u016F translokac\u00ED, i kdy\u017E jsou u nich v translokaci zahrnuty stejn\u00E9 chromosomy."@cs . "Ho\u0159\u00EDnov\u00E1, V." . . "Balanced translocations are associated with infertility, spontaneous abortions and birth defects. We report the analysis, by multicolour fluorescence in situ hybridization (FISH), of meiotic segregation and aneuploidy of chromosomes X, Y, 7, 8 and 21 in sperm from three carriers of two different t(11;18). The prevalence of alternate segregation followed by adjacent 1, adjacent 2, and 3:1 was observed in all three patients. Two carriers of the same translocation differed only in the frequency of adjacent 2 segregation. The carrier of the other translocation showed significantly higher frequency of alternate and less adjacent 1 and 3:1 segregation products. An increased frequency of XY, YY and diploid sperm was detected in the group of translocation carriers compared to controls. This was caused by elevated frequencies of disomy and diploidy in two of our carriers. The incidence of abnormal gametes varies in the individual carriers even if the same chromosomes are included in the translocation."@en . . "Z(MZE0002716201)" . "3"^^ . . "Meiotick\u00E1 segregace a interchromosom\u00E1ln\u00ED efekt u nositel\u016F translokace t(11;18) studovan\u00E9 metodou Sperm FISH"@cs . "Rube\u0161, Ji\u0159\u00ED" . . "sperm; meiotic segregation; reciprocal translocation; interchromosomal effect"@en . "Sperm fluorescence in situ hybridization study of meiotic segregation and an interchromosomal effect in carriers of t(11;18)" . "4"^^ . .